Results 41 to 50 of about 281,837 (328)
Science Translational Medicine, 2022 Microglia-mediated synaptic loss contributes to the development of cognitive impairments in Alzheimer’s disease (AD). However, the basis for this immune-mediated attack on synapses remains to be elucidated.
J. Spurrier +21 more
semanticscholar +1 more source
Presynaptically Silent Synapses [PDF]
The Neuroscientist, 2011 Synapses represent the main junctures of communication between neurons in the nervous system. In many neurotransmitter systems, a fraction of presynaptic terminals fails to release vesicles in response to action potential stimulation and strong calcium influx.
Devon C, Crawford, Steven, Mennerick
openaire +2 more sources
Neural Regeneration Research, 2023 During the development of the nervous system, there is an overproduction of neurons and synapses. Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or strengthening. We have
Josep Tomàs +9 more
doaj +1 more source
Why Neurons Have Thousands of Synapses, A Theory of Sequence Memory in Neocortex [PDF]
, 2015 Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables.
Ahmad, Subutai, Hawkins, Jeff
core +3 more sources
bioRxiv, 2023 A morphologically present but non-functioning synapse is termed a silent synapse. Silent synapses are categorized into “postsynaptically silent synapses,” where AMPA receptors are either absent or non-functional, and “presynaptically silent synapses ...
Otoya Kitaoka +7 more
semanticscholar +1 more source
Postsynaptically Silent Synapses in Single Neuron Cultures [PDF]
Neuron, 1998 We have used the synapses that isolated hippocampal cells in culture form onto themselves (autapses) to determine if some synapses lack functional AMPA receptors (AMPARs). A comparison of the synaptic variability of the AMPAR- and NMDAR-mediated evoked responses, as well as of miniature synaptic responses, indicates that a population of events exists ...
Gomperts, Stephen N +4 more
openaire +2 more sources
Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse [PDF]
, 2019 In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the CNS. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs ...
Elgoyhen, Ana Belen +5 more
core +1 more source
bioRxiv, 2021 Competing accounts propose that working memory (WM) is subserved either by persistent activity in single neurons, or by time-varying activity across a neural population, or by activity-silent mechanisms carried out by hidden internal states of the neural
Maurizio De Pittà, N. Brunel
semanticscholar +1 more source
Network self-organization explains the statistics and dynamics of synaptic connection strengths in cortex [PDF]
, 2013 The information processing abilities of neural circuits arise from their synaptic connection patterns. Understanding the laws governing these connectivity patterns is essential for understanding brain function.
Dimitrakakis, Christos +2 more
core +6 more sources
eLife, 2015 Kainate receptors (KARs) are a subfamily of glutamate receptors mediating excitatory synaptic transmission and Neto proteins are recently identified auxiliary subunits for KARs. However, the roles of Neto proteins in the synaptic trafficking of KAR GluK1
Nengyin Sheng +4 more
doaj +1 more source