Results 41 to 50 of about 24,094 (177)

Microglia shape presynaptic properties at developing glutamatergic synapses [PDF]

, 2019
Deficient neuron-microglia signaling during brain development is associated with abnormal synaptic maturation. However, the precise impact of deficient microglia function on synaptic maturation and the mechanisms involved remain poorly defined.
Arnoux, Bollinger, Cantaut-Belarif, Constantine-Paton, Conti, De Biase, Dobrunz, Doorn, Dumas, Durand, Durand, Gasparini, Gosselin, Grabert, Hellwig, Hessler, Hoshiko, Hsia, Isaac, Khazipov, Korber, Kullmann, Lam, Lavin, Limatola, Lowery, Maggi, Milior, Miyamoto, Mosser, Nimmerjahn, Pagani, Paolicelli, Paolicelli, Parkhurst, Pascual, Pfeiffer, Piccinin, Ragozzino, Renger, Reshef, Reshef, Ricci-Tersenghi, Sallert, Santello, Schafer, Schecter, Sellner, Semple, Singh, Stevens, Tian, Tremblay, Tremblay, Voronin, Wake, Wasling, Weinhard, Winkler, Wolf, Yoon, Zhan   +61 more
core   +1 more source

An opposing function of paralogs in balancing developmental synapse maturation.

PLoS Biology, 2018
The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process ...
Plinio D Favaro, Xiaojie Huang, Leon Hosang, Sophia Stodieck, Lei Cui, Yu-Zhang Liu, Karl-Alexander Engelhardt, Frank Schmitz, Yan Dong, Siegrid Löwel, Oliver M Schlüter   +10 more
doaj   +1 more source

Self-repair in a Bidirectionally Coupled Astrocyte-Neuron (AN) System based on Retrograde Signaling

Frontiers in Computational Neuroscience, 2012
In this paper we demonstrate that retrograde signaling via astrocytes may underpin self-repair in the brain. Faults manifest themselves in silent or near silent neurons caused by low transmission probability synapses; the enhancement of the transmission ...
John eWade, Liam J McDaid, Jim eHarkin, Vincenzo eCrunelli, Scott eKelso   +4 more
doaj   +1 more source

Hardware-Amenable Structural Learning for Spike-based Pattern Classification using a Simple Model of Active Dendrites [PDF]

, 2014
This paper presents a spike-based model which employs neurons with functionally distinct dendritic compartments for classifying high dimensional binary patterns.
Basu, Arindam, Hussain, Shaista, Liu, Shih-Chii   +2 more
core   +2 more sources

ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function

Cell Reports, 2016
The molecular mechanisms that promote excitatory synapse development have been extensively studied. However, the molecular events preventing precocious excitatory synapse development so that synapses form at the correct time and place are less well ...
W. Ba, M.M. Selten, J. van der Raadt, H. van Veen, L.-L. Li, M. Benevento, A.R. Oudakker, R.S.E. Lasabuda, S.J. Letteboer, R. Roepman, R.J.A. van Wezel, M.J. Courtney, H. van Bokhoven, N. Nadif Kasri   +13 more
doaj   +1 more source

Cortical circuit alterations precede motor impairments in Huntington's disease mice [PDF]

, 2019
Huntington's disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human patients and mouse HD models suggest that disturbances of neuronal function in the neocortex ...
Arzberger, T., Bader, J., Burgold, J., Dudanova, I., Gutierrez-Angel, S., Hosp, F., Klein, R., Liebscher, S., Mann, M., Schulz-Trieglaff, E., Voelkl, K.   +10 more
core   +1 more source

Synaptically silent sensory hair cells in zebrafish are recruited after damage

Nature Communications, 2018
Hair cells of the inner ear are mechanosensors that detect sound, and synapse onto afferent neurons. Here, the authors used calcium imaging to find that not all hair cells are synaptically engaged, but after damage these silent cells are synaptically ...
Qiuxiang Zhang, Suna Li, Hiu-Tung C. Wong, Xinyi J. He, Alisha Beirl, Ronald S. Petralia, Ya-Xian Wang, Katie S. Kindt   +7 more
doaj   +1 more source

Programmable van‐der‐Waals heterostructure‐enabled optoelectronic synaptic floating‐gate transistors with ultra‐low energy consumption

InfoMat, 2022
Van der Waals (vdW) heterostructures provide a unique opportunity to develop various electronic and optoelectronic devices with specific functions by designing novel device structures, especially for bioinspired neuromorphic optoelectronic devices, which
Yilin Sun, Mingjie Li, Yingtao Ding, Huaipeng Wang, Han Wang, Zhiming Chen, Dan Xie   +6 more
doaj   +1 more source

Distinct Translaminar Glutamatergic Circuits to GABAergic Interneurons in the Neonatal Auditory Cortex

Cell Reports, 2017
GABAergic activity is important in neocortical development and plasticity. Because the maturation of GABAergic interneurons is regulated by neural activity, the source of excitatory inputs to GABAergic interneurons plays a key role in development.
Rongkang Deng, Joseph P.Y. Kao, Patrick O. Kanold   +2 more
doaj   +1 more source

Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord [PDF]

, 2009
Pure NMDA receptor (NMDAr)-mediated EPSCs, thought to correspond to "silent" glutamatergic synapses that lack AMPA receptors (AMPArs), have been observed in superficial spinal dorsal horn of neonatal but not adult rats.
Hughes, D.I., Nagy, G.G., Polgár, Erika, Riddell, J.S., Todd, A.J., Watanabe, M., Yasaka, T.   +6 more
core   +3 more sources