Results 51 to 60 of about 24,094 (177)
Presynaptically Silent GABA Synapses in Hippocampus [PDF]
Mammalian central synapses commonly specialize in one fast neurotransmitter, matching the content of their presynaptic vesicles with the appropriate receptors in their postsynaptic membrane. Here, I show that hippocampal cultures contain autaptic glutamatergic synapses that contravene this rule: in addition to postsynaptic glutamate receptors, they ...
openaire +4 more sources
Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause.
Sukjin Ko+7 more
doaj +1 more source
Stochastic Synapses Enable Efficient Brain-Inspired Learning Machines [PDF]
Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines, a class of neural network models that uses synaptic stochasticity
Al-Shedivat, Maruan+4 more
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Spinal cord injury (SCI) leads to devastating physical consequences, such as severe sensorimotor dysfunction even lifetime disability, by damaging the corticospinal system.
Mingcong Chen+7 more
doaj
‘Deaf, mute and whispering’ silent synapses: their role in synaptic plasticity
Mechanisms of long‐term potentiation (LTP) maintenance are discussed in the light of the phenomenon of silent synapses. Evidence that LTP is associated with the insertion of new AMPA receptors (AMPARs) in postsynaptically silent (deaf) synapses expressing only NMDA receptors (NMDARs) before LTP induction has led to the assumption that the debate on pre‐
L. L. Voronin, Enrico Cherubini
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The role of inhibitory feedback for information processing in thalamocortical circuits [PDF]
The information transfer in the thalamus is blocked dynamically during sleep, in conjunction with the occurence of spindle waves. As the theoretical understanding of the mechanism remains incomplete, we analyze two modeling approaches for a recent ...
A. Destexhe+23 more
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Silent Synapses in Neural Plasticity: Current Evidence [PDF]
Silent synapses, defined as structural specializations for neurotransmission that do not produce a physiological response in the receiving cell, may occur frequently in neural circuits. Their recruitment to physiological effectiveness may be an important component of circuit modification.
J. Martin Wojtowicz, Harold L. Atwood
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Synfire chains are thought to underlie precisely-timed sequences of spikes observed in various brain regions and across species. How they are formed is not understood. Here we analyze self-organization of synfire chains through the spike-timing dependent
Jin, Dezhe Z., Miller, Aaron
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Recent work has shown that thalamocortical (TC) inputs can be plastic after the developmental critical period has closed, but the mechanism that enables re-establishment of plasticity is unclear.
Seungsoo Chung+6 more
doaj +1 more source
Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]
Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor ...
Park, Choongseok, Rubchinsky, Leonid
core +3 more sources