MicroRNA-137 Controls AMPA-Receptor-Mediated Transmission and mGluR-Dependent LTD
Cell Reports, 2015 Mutations affecting the levels of microRNA miR-137 are associated with intellectual disability and schizophrenia. However, the pathophysiological role of miR-137 remains poorly understood.
Nikkie F.M. Olde Loohuis +9 more
doaj +1 more source
Modeling the Contributions of the Exocytotic Machinery and Receptor Desensitization to Short- and Long-Term Plasticity of Synapses Between Neocortical Pyramidal Neurons [PDF]
, 2001 Short-term synaptic depression (STD) refers to the progressive decrease in synaptic efficacy during a spike train. This decrease may be explained in terms of presynaptic and postsynaptic processes, such as a decrease in the probability of transmitter ...
Cohen, Michael, Okatan, Murat
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Frontiers in Cellular Neuroscience, 2016 Platelet activating factor (PAF) is an inflammatory phospholipid signaling molecule implicated in synaptic plasticity, learning and memory and neurotoxicity during neuroinflammation.
Jennetta W Hammond +2 more
doaj +1 more source
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]
, 2011 Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun +3 more
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Robust entropy requires strong and balanced excitatory and inhibitory synapses
, 2018 It is widely appreciated that well-balanced excitation and inhibition are necessary for proper function in neural networks. However, in principle, such balance could be achieved by many possible configurations of excitatory and inhibitory strengths, and ...
Agrawal, Vidit +5 more
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Dynamic clamp with StdpC software [PDF]
, 2011 Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs.
A Szücs +51 more
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New Tools for Investigating Astrocyte-to-Neuron Communication
Frontiers in Cellular Neuroscience, 2013 Grey matter protoplasmic astrocytes extend very thin processes and establish close contacts with synapses. It has been suggested that the release of neuroactive gliotransmitters at the tripartite synapse contributes to information processing.
Dongdong eLi +4 more
doaj +1 more source
Variation in early life maternal care predicts later long range frontal cortex synapse development in mice. [PDF]
, 2020 Empirical and theoretical work suggests that early postnatal experience may inform later developing synaptic connectivity to adapt the brain to its environment.
Chang, Irene +3 more
core
Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
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Diminished Neuronal Activity Increases Neuron-Neuron Connectivity Underlying Silent Synapse Formation and the Rapid Conversion of Silent to Functional Synapses [PDF]
The Journal of Neuroscience, 2005 Neuronal activity regulates the synaptic strength of neuronal networks. However, it is still unclear how diminished activity changes connection patterns in neuronal circuits. To address this issue, we analyzed neuronal connectivity and relevant mechanisms using hippocampal cultures in which developmental synaptogenesis had occurred.
Takahisa Taguchi +2 more
openaire +3 more sources