Results 21 to 30 of about 453,809 (210)

ArgD of Mycobacterium tuberculosis is a functional N-acetylornithine aminotransferase with moonlighting function as an effective immune modulator

International Journal of Medical Microbiology, 2022
Mycobacterium tuberculosis (M. tuberculosis) encodes an essential enzyme acetyl ornithine aminotransferase ArgD (Rv1655) of arginine biosynthetic pathway which plays crucial role in M. tuberculosis growth and survival.
Iqra Bashir Nehvi, Neha Quadir, Mohd Khubaib, Javaid Ahmad Sheikh, Mohd Shariq, Krishnaveni Mohareer, Sharmistha Banerjee, Syed Asad Rahman, Nasreen Z. Ehtesham, Seyed E. Hasnain   +9 more
doaj   +1 more source

In silico study of phytochemicals contained in Brucea javanica in inhibiting the InhA enzyme as antituberculosis

Journal of Public Health in Africa, 2023
Background: Currently Mycobacterium tuberculosis is found to be resistant to the treatment of tuberculosis with rifampin and isoniazid (INH) and often stated as multi-drug resistance (MDR).
Melanny I. Sulistyowaty, Galih S. Putra, Juni Ekowati, Tri Widiandani, Katsuyoshi Matsunami   +4 more
doaj   +1 more source

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]

, 2007
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R, Friggen, Annemieke H, Geluk, Annemieke, Lin, May Young, Verduyn, Marleen JC, Voskuil, Martin I, Huygen, Kris, Franken, Kees LMC, Smith, Steven G, van Meijgaarden, Krista E, Dockrell, Hazel M, Stewart, Amanda L, Ottenhoff, Tom HM   +12 more
core   +1 more source

Antimycobacterial activity and molecular docking of methanolic extracts and compounds of marine fungi from Saldanha and False Bays, South Africa

Heliyon, 2022
The number and diversity of drugs in the tuberculosis (TB) drug development process has increased over the years, yet the attrition rate remains very high, signaling the need for continued research in drug discovery.
Kudzanai Ian Tapfuma, Kudakwashe Nyambo, Francis Adu-Amankwaah, Lucinda Baatjies, Liezel Smith, Nasiema Allie, Marshall Keyster, Andre G. Loxton, Mkhuseli Ngxande, Rehana Malgas-Enus, Vuyo Mavumengwana   +10 more
doaj   +1 more source

Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways

mSystems, 2019
A better understanding of essential cellular functions in pathogenic bacteria is important for the development of more effective antimicrobial agents. We performed a comprehensive identification of essential genes in Mycobacterium tuberculosis, the major
Yusuke Minato, Daryl M. Gohl, Joshua M. Thiede, Jeremy M. Chacón, William R. Harcombe, Fumito Maruyama, Anthony D. Baughn   +6 more
doaj   +1 more source

Discovery of new naphthyridine hybrids against enoyl-ACP reductase (inhA) protein target of Mycobacterium tuberculosis: Molecular docking, molecular dynamics simulations studies

Chemical Physics Impact, 2023
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and remains a significant global public health concern, with many new cases reported annually.
Govindaraj Sabarees, Vadivel Velmurugan, Viswas Raja Solomon   +2 more
doaj   +1 more source

Influences of radiographic silicosis and drug supervisor on the development of multi drug resistant-tuberculosis in West Java, Indonesia

Environmental Health and Preventive Medicine
Background: Indonesia is among countries with a high incidence of multi drug-resistant tuberculosis (MDR-TB) globally. In this study, we aim to determine the prevalence of silico-tuberculosis among TB patients and to investigate the association of ...
Leli Hesti Indriyati, Masamitsu Eitoku, Naw Awn J-P, Miki Nishimori, Norihiko Hamada, Neni Sawitri, Narufumi Suganuma   +6 more
doaj   +1 more source

Computational identification of significant immunogenic epitopes of the putative outer membrane proteins from Mycobacterium tuberculosis

Journal of Genetic Engineering and Biotechnology, 2021
Novel vaccines are required to effectively combat the epidemic spread of tuberculosis. Using in silico approaches, this study focuses on prediction of potential B cell and T cell binding immunogenic epitopes for 30 putative outer membrane proteins of Mtb.
Shobana Sundar, Lokesh Thangamani, Shanmughavel Piramanayagam   +2 more
doaj   +1 more source

PolyTB: a genomic variation map for Mycobacterium tuberculosis [PDF]

, 2014
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second major cause of death from an infectious disease worldwide. Recent advances in DNA sequencing are leading to the ability to generate whole genome information in clinical isolates ...
Gagneux, S., Perdigão, João, McNerney, R., Glynn, Judith R., McNerney, Ruth, Preston, M., Perdigao, J., Gagneux, Sebastien, Viveiros, M., Glynn, Judith R, Guerra-Assunção, José Afonso, Glynn, J., Parkhill, J., Harris, D., Clark, T., Coll, Francesc, Viveiros, Miguel, Hill-Cawthorne, G., Hill-Cawthorn, Grant, Pain, A., Pain, Arnab, Clark, Taane G., Portugal, I., Parkhill, Julian, Preston, Mark, Drobniewski, Francis, Drobniewski, F., Portugal, Isabel, Martin, Nigel, Guerra-Assuncao, J., Harris, David, Coll, F., Clark, Taane G   +32 more
core   +1 more source

Exploring Withania somnifera derived natural products as promising inhibitors of Mycobacterium tuberculosis Pantothenate Kinase-PanK: An integrated in silico and in vitro approach

Journal of Ayurveda and Integrative Medicine
Background: Tuberculosis remains a pervasive and enduring global health challenge, with the alarming rise of drug-resistant variants. Mycobacterium tuberculosis (M.
Ankita Singh, Usha Mina, Pardeep Yadav
doaj   +1 more source