Results 1 to 10 of about 38,173 (247)

CC-chemokine ligand 18, CXC motif chemokine 13 and osteopontin as biomarkers of silicosis and asbestosis: a prospective observational study [PDF]

Scientific Reports
Background Silicosis and asbestosis, distinct forms of pneumoconiosis, manifest progressive interstitial fibrosis due to exposure to silica dust or asbestos fibers. This study aimed to identify potential biomarkers for diagnosing silicosis and asbestosis,
Na Wu, Changjiang Xue, Shiwen Yu, Yuanying Wang, Di Sun, Qiao Ye   +5 more
doaj   +2 more sources

OC-STAMP is a potential biomarker and therapeutic target for Silicosis: an exploratory investigation [PDF]

Journal of Translational Medicine
Background Silicosis, a disease characterized by fibrous changes in lung tissue due to prolonged silica dust inhalation, exhibits a complex pathogenesis that remains inadequately addressed by current interventions.
Jing Wu, Bingyu Zhang, Wei Du, Yimin Shi, Chunhong Xie, Yanyan Ke, Xue Yi   +6 more
doaj   +2 more sources

Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil [PDF]

Jornal Brasileiro de Pneumologia
Objective: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by the inhalation of silica particles. Silica dust inhalation is associated with inflammation and induction of oxidative stress in the lungs.
Marcos César Santos de Castro, Lucas de Carvalho Costa, Kaio Cezar Rodrigues Salum, Hermano Albuquerque de Castro, Patrícia Canto Ribeiro, Walter Costa, Angela Santos Ferreira Nani, Fabiana Barzotto Kohlrausch   +7 more
doaj   +2 more sources

Health and safety in 3D printing

International Journal of Occupational and Environment Safety, 2022
Fused deposition modelling, or 3D printing, is an additive manufacturing technique that is quickly gaining popularity because of its ability to produce usable parts with several geometries. It provides multiple advantages in everyday life.
Héctor García, Teresa López Pola
doaj   +1 more source

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

PLoS Genetics, 2022
Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and ...
Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin   +12 more
doaj   +2 more sources

Particulate Matter Characterization in a Hospital’s Underground Car Park

Powders, 2022
The air quality in a hospital’s underground car park is a concern because diesel fumes from cars impact upon vulnerable people attending medical consultations. This research aims to quantify the potential health risk associated with a particular hospital
Hector Garcia-Gonzalez, Maida Domat, Teresa Lopez-Pola, Pilar Fernandez-Rubio, Pablo Fernandez-Rodriguez   +4 more
doaj   +1 more source

Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis Treatment

Frontiers in Genetics, 2021
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, which may not perfectly reflect the nature of human
Junling Pang, Ya Luo, Dong Wei, Zhujie Cao, Xianmei Qi, Meiyue Song, Ying Liu, Zhaoguo Li, Jin Zhang, Baicun Li, Jingyu Chen, Jingyu Chen, Jing Wang, Chen Wang   +13 more
doaj   +1 more source

The exhaustion of lymphocytes is the main factor that decreases the sensitivity of QFT-GIT detection in silicosis

BMC Immunology, 2022
Background Tuberculosis infection is a major complication of silicosis, but there is no study on whether silicosis can affect the sensitivity of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays.
Xin Yu, Li-Na Huang, Jun-Chi Xu, Yi-Yan Song, Hui Chen, Cui-Lin Shi, Pei-Jun Tang, Tao Tao, Ye-Han Zhu   +8 more
doaj   +1 more source

Distinct metabolic features in the plasma of patients with silicosis and dust-exposed workers in China: a case–control study

BMC Pulmonary Medicine, 2021
Background Silicosis is a progressive pneumoconiosis characterized by interstitial fibrosis following exposure to silica dust. The role of metabolic dysregulation in the pathogenesis of silicosis has not been investigated in detail.
Changjiang Xue, Na Wu, Yali Fan, Jing Ma, Qiao Ye   +4 more
doaj   +1 more source

Integrating RNA-Seq With GWAS Reveals a Novel SNP in Immune-Related HLA-DQB1 Gene Associated With Occupational Pulmonary Fibrosis Risk: A Multi-Stage Study

Frontiers in Immunology, 2022
ObjectiveTo evaluate the association between single-nucleotide polymorphisms (SNPs) in RNA-seq identified mRNAs and silicosis susceptibility.MethodsA comprehensive RNA-seq was performed to screen for differently expressed mRNAs in the peripheral blood ...
Yan Zhou, Yingyi Zhang, Rui Zhao, Zhounan Cheng, Minzhu Tang, Anni Qiu, Yang Dong, Yihua Lu, Yulong Lian, Xun Zhuang, Tian Tian, Wei Wang, Minjie Chu   +12 more
doaj   +1 more source