Results 1 to 10 of about 41,841 (256)
Signal Transduction and Targeted Therapy, 2022 Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, and currently used drugs cannot reverse the disease progress.
Ming-yao Wang, Junling Pang, Hao Yang
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Silica, Silicosis, and Autoimmunity [PDF]
Frontiers in Immunology, 2016 Inhalation of dust containing crystalline silica is associated with a number of acute and chronic diseases including systemic autoimmune diseases. Evidence for the link with autoimmune disease comes from epidemiological studies linking occupational exposure to crystalline silica dust with the systemic autoimmune diseases systemic lupus erythematosus ...
Kenneth Michael Pollard
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The role of inflammation in silicosis
Frontiers in PharmacologySilicosis is a chronic illness marked by diffuse fibrosis in lung tissue resulting from continuous exposure to SiO2-rich dust in the workplace. The onset and progression of silicosis is a complicated and poorly understood pathological process involving ...
Tong-Tong Liu +4 more
doaj +4 more sources
Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice
PLoS Genetics, 2022 Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and ...
Lulu Kang +12 more
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Current global perspectives on silicosis—Convergence of old and newly emergent hazards
Respirology, 2022 Silicosis not a disease of the past. It is an irreversible, fibrotic lung disease specifically caused by exposure to respirable crystalline silica (RCS) dust.
Mohamed F Jeebhay +2 more
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New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis
International Journal of Molecular Sciences, 2021 Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique process in which the vicious cycle of ingestion of inhaled silica particles by alveolar ...
Daniela Mokra
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Archives of Public Health, 2023 Background Differentiated tuberculosis (TB) care is an approach to improve treatment outcomes by tailoring TB management to the particular needs of patient groups based on their risk profile and comorbidities. In silicosis-prone areas, the coexistence of
Mihir P. Rupani
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Early Identification, Accurate Diagnosis, and Treatment of Silicosis
Canadian Respiratory Journal, 2022 Silicosis is a global problem, and it has brought about great burdens to society and patients’ families. The etiology of silicosis is clear, preventable, and controllable, but the onset is hidden and the duration is long.
Tian Li +3 more
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Frontiers in Genetics, 2021 Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, which may not perfectly reflect the nature of human
Junling Pang +13 more
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