Results 1 to 10 of about 50,422 (305)

The role of inflammation in silicosis

Frontiers in Pharmacology
Silicosis is a chronic illness marked by diffuse fibrosis in lung tissue resulting from continuous exposure to SiO2-rich dust in the workplace. The onset and progression of silicosis is a complicated and poorly understood pathological process involving ...
Tong-Tong Liu, Hai-Fei Sun, Yan-Xing Han, Yun Zhan, Jian-Dong Jiang   +4 more
doaj   +4 more sources

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

PLoS Genetics, 2022
Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and ...
Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin   +12 more
doaj   +3 more sources

Current global perspectives on silicosis—Convergence of old and newly emergent hazards

Respirology, 2022
Silicosis not a disease of the past. It is an irreversible, fibrotic lung disease specifically caused by exposure to respirable crystalline silica (RCS) dust.
Ryan Hoy, Mohamed F Jeebhay, Catherine Cavalin   +2 more
exaly   +2 more sources

Silicosis as a predictor of tuberculosis mortality and treatment failure and need for incorporation in differentiated TB care models in India

Archives of Public Health, 2023
Background Differentiated tuberculosis (TB) care is an approach to improve treatment outcomes by tailoring TB management to the particular needs of patient groups based on their risk profile and comorbidities. In silicosis-prone areas, the coexistence of
Mihir P. Rupani
doaj   +2 more sources

Early Identification, Accurate Diagnosis, and Treatment of Silicosis

Canadian Respiratory Journal, 2022
Silicosis is a global problem, and it has brought about great burdens to society and patients’ families. The etiology of silicosis is clear, preventable, and controllable, but the onset is hidden and the duration is long.
Tian Li, Xinyu Yang, Hong Xu, Heliang Liu   +3 more
doaj   +2 more sources

Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration

Signal Transduction and Targeted Therapy, 2022
Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, and currently used drugs cannot reverse the disease progress.
Mingyao Wang, Zhe Zhang, Jiangfeng Liu, Meiyue Song, Tiantian Zhang, Yiling Chen, Huiyuan Hu, Peiran Yang, Bolun Li, Xiaomin Song, Junling Pang, Yanjiang Xing, Zhujie Cao, Wenjun Guo, Hao Yang, Jing Wang, Juntao Yang, Chen Wang   +17 more
doaj   +2 more sources

Current status, trends, and predictions in the burden of silicosis in 204 countries and territories from 1990 to 2019

Frontiers in Public Health, 2023
BackgroundSilicosis, a severe lung disease caused by inhaling silica dust, predominantly affects workers in industries such as mining and construction, leading to a significant global public health challenge.
Xinglin Yi, Yi He, Yu Zhang, Qiuyue Luo, Caixia Deng, Guihua Tang, Jiongye Zhang, Xiangdong Zhou, Hu Luo   +8 more
doaj   +2 more sources

Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis Treatment

Frontiers in Genetics, 2021
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, which may not perfectly reflect the nature of human
Junling Pang, Ya Luo, Dong Wei, Zhujie Cao, Xianmei Qi, Meiyue Song, Ying Liu, Zhaoguo Li, Jin Zhang, Baicun Li, Jingyu Chen, Jingyu Chen, Jing Wang, Chen Wang   +13 more
doaj   +2 more sources

A mixed-methods study on impact of silicosis on tuberculosis treatment outcomes and need for TB-silicosis collaborative activities in India

Scientific Reports, 2023
Globally, silicosis and tuberculosis (TB) have been targeted for elimination by 2030. The study’s objectives were to determine the association of silicosis with unfavorable TB treatment outcomes, as well as to explore experts’ perspectives on improving ...
Mihir P. Rupani
doaj   +2 more sources

Silicosis, progressive massive fibrosis and silico-tuberculosis among workers with occupational exposure to silica dusts in sandstone mines of Rajasthan state: An urgent need for initiating national silicosis control programme in India

Journal of Family Medicine and Primary Care, 2021
Context: Silicosis is a progressive, irreversible and incurable respiratory morbidity and often becomes a cause for pre-mature mortality among occupationally silica dust-exposed workers in India and similar countries.
Subroto S Nandi, Sarang V Dhatrak, Kamalesh Sarkar   +2 more
doaj   +2 more sources