Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosis [PDF]
Ecotoxicology and Environmental SafetyBackground: Silicosis is a lethal occupational disease caused by long-term exposure to respirable silica dust. Pulmonary macrophages play a crucial role in mediating the initiation of silicosis.
Hanyujie Kang +4 more
doaj +2 more sources
Signal Transduction and Targeted Therapy, 2022 Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, and currently used drugs cannot reverse the disease progress.
Ming-yao Wang, Junling Pang, Hao Yang
exaly +2 more sources
One-year lung transplantation outcomes for engineered stone countertop workers with silicosis at a single center in Southern California, 2019 to 2023 [PDF]
JHLT OpenBackground: In the past decade, growing industrial exposure to respirable crystalline silica from manufacturing engineered stone (ES) products has caused rapidly progressive, irreversible silicosis worldwide.
Reice Robinson, MD +13 more
doaj +2 more sources
The Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis [PDF]
International Journal of Molecular Sciences, 2021 Shi Chen
exaly +2 more sources
Environmental Impact of Silicic Magmatism in Large Igneous Province Events
Geophysical Monograph Series, Page 133-151., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Scott E. Bryan
wiley +2 more sources
Health and safety in 3D printing
International Journal of Occupational and Environment Safety, 2022 Fused deposition modelling, or 3D printing, is an additive manufacturing technique that is quickly gaining popularity because of its ability to produce usable parts with several geometries. It provides multiple advantages in everyday life.
Héctor García, Teresa López Pola
doaj +1 more source
Particulate Matter Characterization in a Hospital’s Underground Car Park
Powders, 2022 The air quality in a hospital’s underground car park is a concern because diesel fumes from cars impact upon vulnerable people attending medical consultations. This research aims to quantify the potential health risk associated with a particular hospital
Hector Garcia-Gonzalez +4 more
doaj +1 more source
Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice
PLoS Genetics, 2022 Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and ...
Lulu Kang +12 more
doaj +2 more sources
Targeting the Secretin Receptor in Macrophages Attenuates Silica-Induced Pulmonary Fibrosis. [PDF]
Cell ProlifTargeting macrophage SCTR mitigates integrated profibrotic, inflammatory, ER stress, and senescent pathways, preserving lung function and revealing a novel therapeutic strategy for silicosis.
Li Y +12 more
europepmc +2 more sources
Frontiers in Genetics, 2021 Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, which may not perfectly reflect the nature of human
Junling Pang +13 more
doaj +1 more source