Results 31 to 40 of about 50,422 (305)

Animal models of silicosis: fishing for new therapeutic targets and treatments

European Respiratory Review, 2023
Silicosis as an occupational lung disease has been present in our lives for centuries. Research studies have already developed and implemented many animal models to study the pathogenesis and molecular basis of the disease and enabled the search for ...
A. Martínez-López, S. Candel, S. D. Tyrkalska   +2 more
semanticscholar   +1 more source

The exhaustion of lymphocytes is the main factor that decreases the sensitivity of QFT-GIT detection in silicosis

BMC Immunology, 2022
Background Tuberculosis infection is a major complication of silicosis, but there is no study on whether silicosis can affect the sensitivity of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays.
Xin Yu, Li-Na Huang, Jun-Chi Xu, Yi-Yan Song, Hui Chen, Cui-Lin Shi, Pei-Jun Tang, Tao Tao, Ye-Han Zhu   +8 more
doaj   +1 more source

Global and national burden and trends of mortality and disability-adjusted life years for silicosis, from 1990 to 2019: results from the Global Burden of Disease study 2019

BMC Pulmonary Medicine, 2022
Background Silicosis, as an important type of pneumoconiosis, leads to progressive and irreversible conditions from the beginning of inflammation and fibrosis. However, the data on the global burden of silicosis and long-term trends were limited. Methods
Shimin Chen, Miao Liu, F. Xie
semanticscholar   +1 more source

Distinct metabolic features in the plasma of patients with silicosis and dust-exposed workers in China: a case–control study

BMC Pulmonary Medicine, 2021
Background Silicosis is a progressive pneumoconiosis characterized by interstitial fibrosis following exposure to silica dust. The role of metabolic dysregulation in the pathogenesis of silicosis has not been investigated in detail.
Changjiang Xue, Na Wu, Yali Fan, Jing Ma, Qiao Ye   +4 more
doaj   +1 more source

The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis

BMC Public Health, 2021
Background While the association between occupational inhalation of silica dust and pulmonary tuberculosis has been known for over a century, there has never been a published systematic review, particularly of experience in the current era of less severe
R. Ehrlich, Paula Akugizibwe, N. Siegfried, D. Rees   +3 more
semanticscholar   +1 more source

New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis

International Journal of Molecular Sciences, 2021
Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique process in which the vicious cycle of ingestion of inhaled silica particles by alveolar ...
J. Adamcakova, D. Mokra
semanticscholar   +1 more source

Integrating RNA-Seq With GWAS Reveals a Novel SNP in Immune-Related HLA-DQB1 Gene Associated With Occupational Pulmonary Fibrosis Risk: A Multi-Stage Study

Frontiers in Immunology, 2022
ObjectiveTo evaluate the association between single-nucleotide polymorphisms (SNPs) in RNA-seq identified mRNAs and silicosis susceptibility.MethodsA comprehensive RNA-seq was performed to screen for differently expressed mRNAs in the peripheral blood ...
Yan Zhou, Yingyi Zhang, Rui Zhao, Zhounan Cheng, Minzhu Tang, Anni Qiu, Yang Dong, Yihua Lu, Yulong Lian, Xun Zhuang, Tian Tian, Wei Wang, Minjie Chu   +12 more
doaj   +1 more source

Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis

Occupational and Environmental Medicine, 2022
Objectives To investigate differences in workplace exposure, demographic and clinical findings in engineered stone (ES) workers from a multinational consortium using the Engineered Stone Silicosis Investigators (ESSI) Global Silicosis Registry.
J. Hua, L. Zell-Baran, L. Go, M. Kramer, Johanna B Van Bree, D. Chambers, D. Deller, K. Newbigin, M. Matula, E. Fireman, M. Dahbash, C. Martínez-González, A. León-Jiménez, C. Sack, J. Ferrer, A. Villar, K. Almberg, R. Cohen, C. Rose   +18 more
semanticscholar   +1 more source

Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients

Scientific Reports, 2022
Patients with silicosis caused by occupational exposure to engineered stone (ES) present a rapid progression from simple silicosis (SS) to progressive massive fibrosis (PMF).
Alejandro García-Núñez, G. Jiménez-Gómez, Antonio Hidalgo-Molina, J. Córdoba-Doña, A. León-Jiménez, A. Campos‐Caro   +5 more
semanticscholar   +1 more source

Review on role of NLRP3 inflammasome in pathogenesis of silicosis

环境与职业医学, 2022
Silicosis is one of the most common forms of pneumoconiosis globally. Workers who engage in mining, construction, ceramics, and many other industries have a high risk of developing silicosis. Chronic and repeated inhalation of free silica (SiO2) dust (
Zhenzhen FAN, Yehong ZHAO, Bing LI, Yang LIU, Junyu JIANG, Min MU, Xinrong TAO   +6 more
doaj   +1 more source