Isolation of Active Substances from the Seeds of the Milk Thistle Plant (Silybum marianum) and Determination of Antioxidant Activity [PDF]
Kemija u Industriji, 2011 Isolation of silymarin, a mixture of well-defined flavonolignans, from the seeds of milk thistle (Silybum marianum) was achieved. Silymarin was extracted from defatted seed with acetone without heating; the yield was Y=4.1 %.
Bušić, V. +2 more
doaj +4 more sources
Protective Effect of Silymarin Against Paclitaxel-Induced Cardiotoxicity. [PDF]
Food Sci NutrPaclitaxel, a potent chemotherapeutic agent, induces oxidative stress, inflammation, and apoptosis leading to cardiotoxicity. In this study, silymarin supplementation significantly reduced oxidative stress markers, downregulated inflammatory cytokines (IL‐1β, TNF‐α, NF‐κB), and restored the balance between pro‐ and anti‐apoptotic proteins in rat heart ...
Tutar T +4 more
europepmc +2 more sources
Ameliorative Role of Silymarin in Methotrexate-Induced Pulmonary Damage: A Multi-Pathway Molecular Approach. [PDF]
J Biochem Mol ToxicolMethotrexate (MTX) induces oxidative stress–related lung injury through excessive reactive oxygen species (ROS) production, leading to inflammation, apoptosis, and impaired autophagy. MTX increases lipid peroxidation and disrupts antioxidant defenses (MDA, GSH, SOD, GPx, CAT), while activating inflammatory and apoptotic pathways including TNF‐α, NF‐κB,
Genc A, Sahin E, Cankaya E.
europepmc +2 more sources
Silymarin for HCV infection [PDF]
Antiviral Therapy, 2013 Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions.
Stephen J, Polyak +5 more
openaire +2 more sources
Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]
, 2017 Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto +10 more
core +5 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]
, 2010 Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel +16 more
core +1 more source
Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]
, 2019 The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato +2 more
core +1 more source
PLoS ONE, 2015 Silymarin, a known extract, is used in the treatment of liver diseases with various origins, but its current administration form cannot target the liver because of its poor oral bioavailability. A new type of oral silymarin proliposome aimed at improving
Mei Wang +7 more
doaj +1 more source
In vitro and in vivo anti-cancer activity of silymarin on oral cancer
Tumor Biology, 2018 Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various cancers. Here, we explored the anti-cancer activity of silymarin and its molecular target in human oral cancer in vitro and in vivo ...
Dong-Hoon Won +10 more
doaj +1 more source