Results 91 to 100 of about 94,849 (208)

Has HIV evolved to induce immune pathogenesis? [PDF]

, 2008
Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS.
Bartha, István, Müller, Viktor, Simon, Péter   +2 more
core   +1 more source

The virus lesson: Teaching viral structure and quasi‐symmetry in mixed reality

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Traditional approaches to teaching structural biology struggle to capture the dynamic, three‐dimensional nature of biomolecular structures. Viral capsids, which employ quasi‐symmetric arrangements, are especially difficult to conceptualize at the human scale.
Adam Gardner, Fabien Cannac, Quentin Tallon, Arthur Olson, Ludovic Autin   +4 more
wiley   +1 more source

Co-Transfected SV40 Origin of Replication Activates Expression from SV40 Promoterless Constructs

BioTechniques, 1999
Co-transfection with expression plasmids is widely used to control DNA uptake efficiency in transient transfection experiments. However, a number of problems have been associated with their use.
A. Flint, S. Kaluz, M. Kaluzova, L. Sheldrick, P. Fisher, K. Derecka   +5 more
doaj   +1 more source

Anaerobe‐Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Genital microbiome dysbiosis is an important risk factor for the sexual acquisition of human immunodeficiency virus (HIV) in both the male and female genital tracts. The vaginal, penile and urethral mucosae are distinct microenvironments with characteristic microbiome compositions.
Shirley Constable, Yasamin Minazadeh, Lane B. Buchanan, Henryroger Ssemunywa, Ronald M. Galiwango, Rupert Kaul, Jessica L. Prodger   +6 more
wiley   +1 more source

Production and Purification of Simian Vacuolating Virus40 virus-like particles

四川大学学报. 自然科学版, 2016
Simian virus 40 (SV40) is a member of the Polyomaviridae family .Express the structural protein VP1 of SV40 in Bac-to-Bac baculovirus expression system. The expressed protein will be self-assembled to SV40 virus-like particles (SV40 VLPs).
LIU Rui-Xi, LI Xiao-Yu, YANG Shuo, LI Xiao-Jiao, YANG Zhi-Rong, LIU Lan-Jun, FENG Su   +6 more
doaj  

A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus [PDF]

, 1985
Using the simian virus 40 "enhancer trap" approach, we have identified a transcription enhancer located just upstream of the major immediate early gene of murine cytomegalovirus. This enhancer has several striking properties.
Dorsch-Häsler, Karoline, Jasin, Maria, Keil, Günther M., Koszinowski, Ulrich H., Schaffner, Walter, Weber, Frank   +5 more
core   +1 more source

Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Microglia have been implicated in the templated spread of tau aggregates in tauopathies through mouse studies. However, it is unclear whether these findings translate to human disease. METHODS We challenged human induced pluripotent stem cell (iPSC)‐derived microglia‐like‐cells (iMGL) with monomeric and fibrillar recombinant tau ...
Maria Kreger Karabova, Anna del Ser‐Badia, Anne Hedegaard, Sam J. Washer, Zeynep Baykam, Darragh P. O'Brien, Iolanda Vendrell, Svenja S. Hester, Roman Fischer, Errin Johnson, Charlotte E. Melia, Teige R. S. Matthews‐Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A. Metrick II, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A. McEwan, Kenneth S. Kosik, Theresa A. Day, William S. James, Sally A. Cowley   +22 more
wiley   +1 more source

Decoding HIV‐1 Next Move Through Matrix Protein p17 Quasi‐Species

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
HIV‐1 mutants expressing clonogenic HIV‐1 matrix protein p17 variants (vp17s) are spreading, increasing their prevalence worldwide. In RNA viruses, quasi‐species are transmitted among hosts, leading to the generation of new master sequences. We developed a next‐generation sequence approach to evaluate the frequency of vp17 quasi‐species in people ...
Serena Messali, Anna Bertelli, Marta Giovanetti, Leonardo Sclavi, Massimo Ciccozzi, Mark Slevin, Arnaldo Caruso, Francesca Caccuri   +7 more
wiley   +1 more source

Selective escape from CD8+ T-Cell responses represents a major driving force of Human Immunodeficiency Virus Type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution [PDF]

, 2005
The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen remain unclear.
Allen, T.M., Altfeld, M., Geer, S.C., Kalife, E.T., Moore, C., O'Sullivan, K.M., DeSouza, I., Feeney, M.E., Eldridge, R.L., Maier, E.L., Kaufmann, D.E., Lahaie, M.P., Reyor, L., Tanzi, G., Johnston, M.N., Brander, C., Draenert, R., Rockstroh, J.K., Jessen, H., Rosenberg, E.S., Mallal, S.A., Walker, B.D.   +21 more
core   +2 more sources

Emerging Strategies in the Diagnosis and Treatment of Pleural Mesothelioma: An Overview

Thoracic Cancer, Volume 17, Issue 8, April 2026.
This review examines pleural mesothelioma, from risk factors and pathogenesis to diagnostic approaches and histological classification. We discuss current treatment strategies including chemotherapy and FDA‐approved immunotherapy, alongside emerging therapies such as VISTA, LAG‐3 inhibitors, and dendritic cell‐based approaches for personalized ...
Raffaella Pagliaro, Beatrice Leonardi, Angela Schiattarella, Grazia Bergameo, Carmine Picone, Adolfo Gallipoli D'Errico, Filippo Scialò, Fabio Perrotta, Maria Luisa De Rimini, Alfonso Fiorelli, Andrea Bianco   +10 more
wiley   +1 more source