A fragment of the simian virus 40 early genome can induce tumors in nude mice. [PDF]
, 1985 Cell lines transformed by simian virus 40 mutant F8dl (deleted from 0.168 to 0.424 map units, corresponding to the carboxy-terminal 62% of the wild-type simian virus 40 large tumor antigen) are tumorigenic in nude mice.
Knowles, B B +3 more
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Studies on the transcription of simian virus 40 and adenovirus type 2 [PDF]
, 1974 Both adenovirus 2 and simian virus 40 interact with cultured cells in two different ways. On the one hand, there is a productive or lytic response in which the great majority of the cells yield progeny virus and die, and on the other there is an ...
Phillip A. Sharp +7 more
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Interferon, virus vaccines and antiviral drugs [PDF]
, 2008 The emergence of viruses with zoonotic potential, i.e. with the potential ability to cross species barriers to infect unnatural hosts, poses a huge threat to humans.
Rodrigues, Ana Mara Lopes
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Simian virus 40 efficiently infects human T lymphocytes and extends their lifespan [PDF]
, 2012 The relevance of viral infections to the onset/progression of human hematologic malignancies and other blood diseases is still a matter of active investigation.
Maniero S +14 more
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Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas
Molecular Cancer, 2007 Silencing of Fra-1, a component of the dimeric transcription factor, activator protein-1 (AP-1), inhibits mRNA expression of c-met and cd44 in rat mesothelioma cells and is causally linked to maintenance of the transformed phenotype.
Pass Harvey +3 more
doaj +1 more source
Cell Transplantation, 2001 Current clinical reports have indicated that hepatocyte transplantation (HTX) could be used in patients with liver failure and in children with liver-based metabolic diseases. One of the major limiting factors of HTX is a serious shortage of donor livers
Naoya Kobayashi M.D., Ph.D. +8 more
doaj +1 more source
Therapeutic Advances in Vaccines and Immunotherapy, 2020 CD8 + T-cell exhaustion is a dysfunctional state that is regulated through the expression of inhibitory checkpoint receptor genes including the cytotoxic T-lymphocyte–associated antigen 4, programmed death 1, and DNA methylation of effector genes ...
José Belizário +1 more
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Expression of 100,000-Mr simian virus 40 (SV40) tumor antigen in mouse fibroblasts transfected with replication-defective SV40 genomes [PDF]
, 1986 Simian virus 40 early region mutants which are partially or completely replication defective were tested for their ability to transform postcrisis mouse fibroblasts. All mutants tested were capable of generating anchorage-independent transformants.
Verderame, M F, Pollack, Robert
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Simian Virus 40 DNA Sequences in DNA of Healthy Adult Mice Derived from Preimplantation Blastocysts Injected with Viral DNA [PDF]
, 1974 SIMIAN VIRUS 40 DNA SEQUENCES IN DNA OF HEALTHY ADULT MICE DERIVED FROM PREIMPLANTATION BLASTOCYSTS INJECTED WITH VIRAL DNA Simian Virus 40 DNA Sequences in DNA of Healthy Adult Mice Derived from Preimplantation Blastocysts Injected with Viral DNA (71) (
Jaenisch, Rudolf Beatrice Mintz
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Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40 [PDF]
, 2000 A rhesus monkey experimentally inoculated with simian immunodeficiency virus (SIV) mac251 was killed 42 months later because of poor general condition. CD4 lymphocyte count which was 3,430/mm3 before inoculation, had decreased to 638/mm3 2 months before ...
Boche, Delphine +7 more
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