Results 71 to 80 of about 4,147,981 (191)

The Research Progress on Immortalization of Human B Cells

Microorganisms, 2023
Human B cell immortalization that maintains the constant growth characteristics and antibody expression of B cells in vitro is very critical for the development of antibody drugs and products for the diagnosis and bio-therapeutics of human diseases ...
Huiting Xu, Xinxin Xiang, Weizhe Ding, Wei Dong, Yihong Hu   +4 more
doaj   +1 more source

Nonpathogenic SIV Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes

Journal of Medical Primatology, Volume 55, Issue 5, October 2026.
ABSTRACT Introduction Natural hosts of simian immunodeficiency virus (SIV), including sooty mangabeys (SMs), maintain high viremia without progressing to AIDS and AIDS‐associated histopathogenesis. The mechanisms underlying this protection and lack of pathogenesis remain incompletely understood, particularly in relation to monocyte/macrophage ...
Caroline Soulas, Hai Duc Nguyen, Summer Siddiqui, Natalie Stahr, Tricia H. Burdo, Francis J. Novembre, Woong‐Ki Kim, Kenneth C. Williams   +7 more
wiley   +1 more source

Use of Nondefective Adenovirus-Simian Virus 40 Hybrids for Mapping the Simian Virus 40 Genome [PDF]

Journal of Virology, 1973
A series of viable recombinants between adenovirus 2 (Ad2) and simian virus 40 (SV40) (nondefective Ad2-SV40 hybrids) have been isolated. The members of this series (designated Ad2 + ND 1 through Ad2 + ND 5 ) differ from one another in the early
T J, Kelly, A M, Lewis
openaire   +2 more sources

The phylogeography of orangutan foamy viruses supports the theory of ancient repopulation of Sumatra [PDF]

, 2004
Phylogenetic analysis of foamy virus sequences obtained from Bornean and Sumatran orangutans showed a distinct clustering pattern. One subcluster was represented by both Bornean and Sumatran orangutan simian foamy viruses (SFV). Combined analysis of host
Niphuis, H., Heeney, J.L., Fagrouch, Z., Langenhuijzen, S., Warren, K.S., Bontjer, I., Eulenberger, K., Verschoor, E.J.   +7 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, Volume 16, Issue 9, Page 1669-1690, September 2026.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identification of the Simian Virus 40 Which Replicates When Simian Virus 40-Transformed Human Cells Are Fused with Simian Virus 40-Transformed Mouse Cells or Superinfected with Simian Virus 40 Deoxyribonucleic Acid [PDF]

Journal of Virology, 1970
Simian virus 40 (SV40) was rescued from heterokaryons of transformed mouse and transformed human cells. To determine whether the rescued SV40 was progeny of the SV40 genome resident in the transformed mouse cells, the transformed human cells, or both, rescue experiments were performed with mouse lines transformed by plaque morphology mutants of SV40 ...
S, Kit, T, Kurimura, M, Brown, D R, Dubbs   +3 more
openaire   +2 more sources

Investigation into how mitotic spindle checkpoint function is compromised by Sv40 large T antigen. [PDF]

, 2005
The viral oncoprotein Simian virus 40 large T antigen (LT) efficiently immortalises primary rodent cells and occasionally transforms them to tumourigenicity.
Lock, Rowena Lesley, Lock, R.L.
core  

Minimal Genome, Maximal Effect: How Polyomavirus Genomes Are Capable of Complex Pathogenesis

Viruses
The Polyomaviridae family contains members known for achieving high seroprevalence within their target species despite a limited genomic economy. Minimalism, by definition, allows for the clarification and streamlining of purpose via the removal of ...
Michaela Lano, Barry Milavetz
doaj   +1 more source

A Novel, Broad-Acting Peptide Inhibitor of Double-Stranded DNA Virus Gene Expression and Replication

Frontiers in Microbiology, 2020
Viral infections are a global disease burden with only a limited number of antiviral agents available. Due to newly emerging viral pathogens and increasing occurrence of drug resistance, there is a continuous need for additional therapeutic options ...
Zsolt Ruzsics, Zsolt Ruzsics, Zsolt Ruzsics, Katja Hoffmann, Katja Hoffmann, André Riedl, André Riedl, Adalbert Krawczyk, Adalbert Krawczyk, Marek Widera, Marek Widera, Helene Sertznig, Leonie Schipper, Valeria Kapper-Falcone, Valeria Kapper-Falcone, Valeria Kapper-Falcone, Monika Debreczeny, Wolfgang Ernst, Reingard Grabherr, Hartmut Hengel, Hartmut Hengel, Hartmut Hengel, Hanna Harant   +22 more
doaj   +1 more source

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source