Results 61 to 70 of about 59,879 (217)
Simian virus 40 and the human mesothelium [PDF]
Proceedings of the National Academy of Sciences, 2000 Potentially tumorigenic papovaviruses and adenoviruses stimulate host cell DNA synthesis. The induction of an S phase appears to be essential for the integration of the viral genome into host cell DNA. The induction of host cell proliferation is a secondary consequence. Under natural conditions, the risk of malignant growth is counteracted by the viral
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Transforming functions of Simian Virus 40 [PDF]
Oncogene, 2001 Oncogene (2001) 20, 7899–7907.Keywords: SV40; tumor suppressor; chaperone; tumorvirusIntroductionCancer is thought to progress through multiple stageswith each stage giving rise to cells showing increasedmalignant characteristics. Progression through thesestages is driven by genetic events such as mutations intumor suppressor genes or oncogenes, or the
M T, Sáenz-Robles +2 more
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Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells [PDF]
, 1988 We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were ...
Eckhart, W., Meek, D. W.
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Structural Polypeptides of Simian Virus 40 [PDF]
Journal of Virology, 1971 To determine the number and molecular weights of the structural polypeptides of simian virus 40, we have analyzed purified virus by electrophoresis on 14% polyacrylamide gels containing sodium dodecyl sulfate. Full virus purified by several different methods showed six distinct bands with molecular weights of approximately 43,000 (VP1, containing 70 ...
M K, Estes, E S, Huang, J S, Pagano
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Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Investigation into how mitotic spindle checkpoint function is compromised by Sv40 large T antigen. [PDF]
, 2005 The viral oncoprotein Simian virus 40 large T antigen (LT) efficiently immortalises primary rodent cells and occasionally transforms them to tumourigenicity.
Lock, Rowena Lesley, Lock, R.L.
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Biotechnology Reports, 2015 The icosahedral capsid structure of simian virus 40 (diameter, 45 nm) consists of 72 pentameric subunits, with each subunit formed by five VP1 molecules. Electron microscopy, immuno-gold labeling, and ζ-potential analysis showed that purified recombinant
Masaaki Kawano +10 more
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The Research Progress on Immortalization of Human B Cells
Microorganisms, 2023 Human B cell immortalization that maintains the constant growth characteristics and antibody expression of B cells in vitro is very critical for the development of antibody drugs and products for the diagnosis and bio-therapeutics of human diseases ...
Huiting Xu +4 more
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The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease
Brain Pathology, EarlyView.SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery +17 more
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THE FUNCTIONAL ANATOMY OF THE SIMIAN VIRUS 40 REPLICATION ORIGIN. [PDF]
, 1982 THE FUNCTIONAL ANATOMY OF THE SIMIAN VIRUS 40 REPLICATION ...
DERK JON. BERGSMA (7990574)
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