Results 101 to 110 of about 1,429,075 (291)

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

Antioxidant activity of Cheddar cheese during its ripening time and after simulated gastrointestinal digestion as affected by probiotic bacteria

International Journal of Food Properties, 2019
The purpose of our study was to evaluate the effect of the addition of Lactobacillus casei and Lactobacillus plantarum to Cheddar cheese on the antioxidant properties during its ripening time and after simulated gastrointestinal conditions.
Ping Chen, Lu Liu, Xiuxiu Zhang, Awa Fanny Massounga Bora, Xiaodong Li, Mingqi Zhao, Xinyue Hao, Yu Wang   +7 more
doaj   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Polysaccharides from Er Chen Decoction: gastrointestinal fate, gut microbiota modulation and metabolomics

Frontiers in Microbiology
BackgroundEr Chen Decoction (ECD), a classical formula for phlegm-related disorders, contains polysaccharides (PECD) as an important bioactive fraction.
Yu-Jie Liu, Zhi-Kun Wang, Lian-Tao Yue, Dan Qiao, Qiao-Ling Deng, Xiao-Ying Chang, Tong Liu, Mei-Bian Hu   +7 more
doaj   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Modelling the ageing gastrointestinal system in-vitro using whey protein isolate

Food Chemistry: X
The aims of this study were to adapt current in-vitro digestion protocols to replicate older adults suffering from gastrointestinal infections or those on polypharmacy.
Laura Gunning, Michael O'Sullivan, Eugene Dillon, Raquel Cama-Moncunill, Jean-Christophe Jacquier   +4 more
doaj   +1 more source

Rapid start-up of thermophilic anaerobic digestion with the turf fraction of MSW as inoculum [PDF]

, 2011
This study aims to determine suitable start-up conditions and inoculum sources for thermophilic anaerobic digestion. Within days of incubation MSW at 55°C, methane was produced at a high rate.
Suwannoppadol, S., Cord-Ruwisch, R., Ho, G.   +2 more
core  

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

Effects of Simulated Gastrointestinal Digestion on Antioxidant Activities of Individual and Mixed Fruits [PDF]

, 2019
Fruits are important part of dietary pattern and correlated with a lower risk of chronic diseases because they contain many natural antioxidants. The gastrointestinal digestion could affect on antioxidant activities of fruits.
Nie, MD, Lei, Deng, PhD, Gui-Fang, Deng, MD, Xiu-Juan, Wei, MD, Yuan-Huan, Sun, MD, Rui-Fang, Li, PhD, Hua-Bin, Ai, PhD, Wen   +6 more
core