Results 91 to 100 of about 44,341 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Robust optimization for simultaneous localization and mapping [PDF]
, 2012 SLAM (Simultaneous Localization And Mapping) has been a very active and almost ubiquitous problem in the field of mobile and autonomous robotics for over two decades.
Sünderhauf, Niko
core +1 more source
Terrain Elevation Aided Visual Simultaneous Localization and Mapping in Aerial Platforms [PDF]
, 2017 Accurate and precise navigation for aerial platforms is not possible in Global Positioning System denied environment. Several methods to aid Inertial Navigation System have been proposed and used to cope with this problem.
Eyice, Kerem, Culha, Onur
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Basics search for simultaneous localization and mapping. [PDF]
, 2008 This work deals with methods of simultaneous localization and mapping using in mobile robotic problems in the world. Main Goal of the work is describe existing and common using methods of simultaneous localization and mapping.
Gärtner, Jan
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A genetic algorithm for simultaneous localization and mapping [PDF]
2003 IEEE International Conference on Robotics and Automation (Cat. No.03CH37422), 2005 This paper addresses the problem of simultaneous localization and mapping (SLAM) by a mobile robot. The SLAM problem is defined as a global optimization problem in which the objective is to search the space of possible robot maps. A genetic algorithm is described for solving this problem, in which a population of candidate solutions is progressively ...
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source