Results 121 to 130 of about 44,341 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Quaternion-Based Acoustic SLAM for 3D Drone Localization and Source Mapping

IEEE Open Journal of Signal Processing
Accurate localization and mapping are challenging in environments with poor visibility or noise interference, such as underwater, at night, or in fog, where visual data are unreliable or limited.
Hala Abualsaud, Peter Gerstoft
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

RGB-D simultaneous localization and mapping based on combination of static point and line features in dynamic environments [PDF]

, 2018
Visual simultaneous localization and mapping (SLAM) based on RGB-D data has been extensively researched in the past few years and has many robotic applications. Most of the state-of-the-art approaches assume static environments.
Zhang, Huijuan, Yang, Guilin, Fang, Zaojun   +2 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Simultaneous localization and mapping with robots.

, 2005
A fundamental competence of any mobile robot system is the ability to remain localized while operating in an environment. For unknown/partially known environments there is a need to combine localization with automatic mapping to facilitate the localization process. The process of Simultaneous Localization and Mapping (SLAM) is the topic of this thesis.
openaire   +2 more sources

Simultaneous localization and mapping: issues and approaches [PDF]

, 2013
Nowadays, with technological advances in the science of robotics, We've seen building the robots to work autonomously in other planets, under seas and oceans and each unknown environments. Considering that the robots do not have any information about the
Karimi, Ramin, Mahrami, Mohsen, Islam, Md. Nazrul   +2 more
core  

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Improved RTAB-Map Algorithm Based on Visible Light Positioning

IEEE Access
Visible Light Positioning (VLP) is an emerging technology that enables highly accurate indoor localization, especially in areas where GPS is not effective, such as inside buildings. VLP makes use of existing lighting systems but typically requires a high
Po-Hao Hunag, Si-Chuan Liu, Cheng-Hsiung Yang   +2 more
doaj   +1 more source