Results 91 to 100 of about 93,702 (291)

Efficacy of the Biomaterials 3 wt%-nanostrontium-hydroxyapatite-enhanced Calcium Phosphate Cement (nanoSr-CPC) and nanoSr-CPC-incorporated Simvastatin-loaded Poly(lactic-co-glycolic-acid) Microspheres in Osteogenesis Improvement [PDF]

, 2016
Aims The purpose of this multi-phase explorative in vivo animal/surgical and in vitro multi-test experimental study was to (1) create a 3 wt%-nanostrontium hydroxyapatite-enhanced calcium phosphate cement (Sr-HA/CPC) for increasing bone formation and (2)
Masaeli, Reza, Jafarzadeh Kashi, Tahereh S., Dinarvand, Rassoul, Rakhshan, Vahid, Shahoon, Hossein, Hooshmand, Behzad, Abbas, Fatemeh Mashhadi, Raz, Majid, Rajabnejad, Alireza, Eslami, Hossein, Khoshroo, Kimia, Tahriri, Mohammadreza, Tayebi, Lobat   +12 more
core   +1 more source

Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]

, 2015
Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo, Stergiopulos, Nikolaos, Trachet, Bram   +2 more
core   +2 more sources

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism.

PLoS ONE, 2019
Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. In vivo effects of drugs are complicated by several factors and
Mais Absi, Basma G Eid, Nick Ashton, George Hart, Alison M Gurney   +4 more
doaj   +1 more source

The Recruitment and Retention of Individuals With Intellectual Disability in Randomized Controlled Trials: A Scoping Review

British Journal of Learning Disabilities, EarlyView.
ABSTRACT Background People with intellectual disabilities face significant health disparities and often encounter barriers in accessing healthcare services. Although research supports the need for reasonable adjustments to improve healthcare access for this population, implementation in acute healthcare settings remains limited.
Owen Doody, Louise Murphy, Ruth Ryan, Rosemary Lyons, Wenyi Tang, Lorna Bourke   +5 more
wiley   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

Long‐term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Introduction Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder associated with an increased risk of cutaneous tumors. Objectives To develop a feasible and easy‐to‐apply treatment regimen for long‐time disease control of DSAP including prevention of new skin tumors. Patients and Methods 19 patients with DSAP
Berenice M. Lang, Gregor Ojak, Mandy Crummenauer, Joanna Wegner, Caroline Mann, Stephan Grabbe, Petra Staubach   +6 more
wiley   +1 more source

Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation

Journal of Biomedical Science, 2010
Background 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular risk. These statins (i.e., simvastatin) may exert other effects besides from their cholesterol-lowering actions ...
Hou Ssu-Yu, Jayakumar Thanasekaran, Chou Duen-Suey, Chen Wei-Fan, Lee Ye-Ming, Lee Jie-Jen, Hsiao George, Sheu Joen-Rong   +7 more
doaj   +1 more source

Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION. [PDF]

, 2016
OBJECTIVES: The aim of this study was to assess for a treatment interaction between statin use and exercise training (ET) response. BACKGROUND: Recent data suggest that statins may attenuate ET response, but limited data exist in patients with heart ...
Cooper, Lawton S., Dunning, Allison, Fiuzat, Mona, Fleg, Jerome L., Kelly, Jacob P., Keteyian, Steven J., Kitzman, Dalane W., Kraus, William E., Leifer, Eric S., Mentz, Robert J., O\u27Connor, Christopher M., Pina, Ileana L., Schulte, Phillip J., Whellan, David J.   +13 more
core   +1 more source