Results 91 to 100 of about 46,710 (255)

Atorvastatin compared with simvastatin-based therapies in the management of severe familial hyperlipidaemias

, 1999
We compared atorvastatin with simvastatin-based therapies in a prospective observational study of 201 patients with severe hyperlipidaemia. Atorvastatin 10 mg therapy was substituted for simvastatin 20 mg, 20 mg for 40 mg, 40 mg for simvastatin 40 mg ...
Lumb, P J, Semra, Y, Crook, M A, Wierzbicki, A S, Christ, E R, Chik, G   +5 more
core   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism.

PLoS ONE, 2019
Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. In vivo effects of drugs are complicated by several factors and
Mais Absi, Basma G Eid, Nick Ashton, George Hart, Alison M Gurney   +4 more
doaj   +1 more source

Comparative efficacy of pitavastatin and simvastatin in patients with hypercholesterolemia: a meta-analysis of randomized controlled clinical trials

, 2015
Ning Ma,1,2 Lianqun Cui1 1Department of Cardiology, Shandong Provincial Hospital, Shandong University, 2Department of Cardiology, Heze Municipal Hospital, Heze, Shandong, People's Republic of China Background: Simvastatin is a statin used to lower ...
Ma N, Cui LQ
core  

Long‐term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Introduction Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder associated with an increased risk of cutaneous tumors. Objectives To develop a feasible and easy‐to‐apply treatment regimen for long‐time disease control of DSAP including prevention of new skin tumors. Patients and Methods 19 patients with DSAP
Berenice M. Lang, Gregor Ojak, Mandy Crummenauer, Joanna Wegner, Caroline Mann, Stephan Grabbe, Petra Staubach   +6 more
wiley   +1 more source

Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells’ osteogenic differentiation

, 2015
I-Chun Tai,1–3 Yao-Hsien Wang,3 Chung-Hwan Chen,3,4 Shu-Chun Chuang,3 Je-Ken Chang,3–5 Mei-Ling Ho1–3,6 1Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Physiology, College of ...
Tai IC, Ho ML, Chang JK, Chuang SC, Chen CH, Wang YH   +5 more
core  

Oral Semaglutide 25 mg Versus Orforglipron 36 mg in Obesity: A Population‐Adjusted Indirect Treatment Comparison

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study aimed to indirectly compare the effects of oral semaglutide 25 mg versus orforglipron 36 mg on body weight loss, other cardiometabolic biomarkers, and tolerability in adults with overweight (body mass index [BMI] ≥ 27 kg/m2 and at least one obesity‐related complication) or obesity (BMI ≥ 30 kg/m2), without diabetes, using data ...
Wojciech Michalak, Martin Bøg, Theiss Bendixen, Rohan Chowdhury, Phoebe Cowley, Christian Laugesen, Naveen Rathor, Robert F. Kushner   +7 more
wiley   +1 more source

The possible ameliorating effect of platelet-rich plasma on simvastatin induced skeletal myopathy in adult male albino rats. A histological study.

The Egyptian Journal of Histology
Introduction: Simvastatin becomes one of the most administered medications in cases of hyperlipidemia. Simvastatin is strongly associated with skeletal myopathy when compared to other statins.
Nesrine elhomosany, Heba Ibrahim, Abeer Ahmed   +2 more
doaj   +1 more source

Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats

, 2016
Mireia Campos-Martorell,1 Mary Cano-Sarabia,2 Alba Simats,1 Mar Hernández-Guillamon,1 Anna Rosell,1 Daniel Maspoch,2,3 Joan Montaner1,4 1Neurovascular Research Laboratory, Institut de Recerca Vall d’Hebron, Universitat Autònoma de ...
Cano-Sarabia M, Campos-Martorell M, Rosell A, Simats A, Montaner J, Hernández-Guillamon M, Maspoch D   +6 more
core  

Safety and Effectiveness of Glecaprevir/Pibrentasvir in Children and Adolescents With Chronic Hepatitis C: Reports From All‐Case Post‐Marketing Surveillance in Japan

Hepatology Research, EarlyView.
ABSTRACT Aim The aim of this all‐case post‐marketing study was to evaluate the real‐world safety and effectiveness in all children and adolescents with chronic hepatitis C with or without compensated cirrhosis treated with glecaprevir/pibrentasvir (G/P) in Japan. Methods This prospective, observational post‐marketing surveillance study was conducted at
Tatsuki Mizuochi, Katsuyoshi Kawana, Mariko Kobayashi, Eri Iwashita, Itaru Iwama, Daiki Abukawa, Hitoshi Tajiri   +6 more
wiley   +1 more source