Results 111 to 120 of about 50,616 (252)

Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly

Periodontology 2000, EarlyView.
Abstract Objectives This review synthesizes evidence regarding the prevalence, epidemiological associations, and mechanistic pathways between osteoporosis, periodontal disease, and dental implant therapy. Materials and Methods A literature review was conducted to identify studies focused on: osteoporosis, periodontal disease, and dental implants ...
Samin Sirous, Jaclyn C. Chalmers, Pin‐Ying Li, Yumna Subhani, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Simvastatin-induced neuroprotective effect after brain injury is mediated by mitochondrial protection through modulation of the 18 ​kDa translocator protein

Neurotherapeutics
Traumatic brain injury (TBI) remains a leading cause of mortality and chronic disability. Among therapeutic agents investigated, simvastatin has emerged as a potential therapeutic opportunity for management of TBI although its mechanism of action has not
Reem Sakas, Tom Fishboom, Aviv Ben-Menashe, Yaseen Awad-Igbaria, Rana Nasra, Abraham O. Samson, Eilam Palzur, Jean F. Soustiel   +7 more
doaj   +1 more source

Lack of Efficacy of Simvastatin Adjunctive Therapy for Patients with Schizophrenia: A Meta-Analysis of Randomized Controlled Trials [PDF]

Junyu Chen,1,* Yupei Yuan,2,* Ying Hu,1 Liang Liang1,3 1Department of Psychology, The Fourth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China; 2Department of Cardiology, Renmin Hospital of Wuhan ...
Hu Y, Chen J, Liang L, Yuan Y
core  

Effect of repeated hot water immersion on cognitive performance, cerebrovascular function, sleep and biomarkers of neurodegeneration in older adults

Experimental Physiology, EarlyView.
Abstract Ageing is associated with cognitive decline and increased risk of developing neurodegenerative disease. Repeated passive heating, using hot water immersion (HWI), may improve cognitive performance via improved cerebral oxygenation, but this is yet to be examined in older adults.
Daniel D. Piccolo, Jo Corbett, Joseph T. Costello, Thomas B. Williams, Thomas J. James, Janis K. Shute, Mohammad G. A. Alnajjar, Luke C. Hudson, Poppy A. Marsh, Veronika Praskacova, Harry S. Mayes, Michael Tipton, Maria Perissiou, Melitta A. McNarry, Kelly A. Mackintosh, Zoe L. Saynor, Anthony I. Shepherd   +16 more
wiley   +1 more source

Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

, 2016
MMR Meor Mohd Affandi,1,2 Minaketan Tripathy,1,3 Syed Adnan Ali Shah,3,4 ABA Majeed1,3 1Laboratory of Fundamental Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia; 2DDH Core, Universiti ...
Shah SAA, Tripathy M, Meor Mohd Affandi MMR, Majeed ABA   +3 more
core  

Effect of repeated hot water immersion on muscle strength, power, function and physical activity in healthy older adults: A randomised crossover trial

Experimental Physiology, EarlyView.
Abstract Ageing leads to an increased prevalence of sarcopenia and frailty, characterised by progressive declines in muscle strength, power and function and reduced physical activity. Hot water immersion (HWI) could potentially improve muscle function, but this is yet to be explored in older adults.
Daniel D. Piccolo, Jo Corbett, Timothy A. Exell, Joseph M. Moore, Amy Wright, Mohammad G. A. Alnajjar, Luke C. Hudson, Poppy A. Marsh, Veronika Praskacova, Melitta A. McNarry, Kelly A. Mackintosh, Zoe L. Saynor, Anthony I. Shepherd   +12 more
wiley   +1 more source

Simvastatin Encapsulation in Alginate-Based Microspheres

, 2016
Despite the great success of hip implant surgeries, wear particle-induced implant aseptic loosening still limits the implant longevity. Simvastatin, an FDA-approved cholesterol lowering statin, is a promising drug candidate for the treatment of implant ...
Parsian, Ava
core   +1 more source

The acute effects of exercise intensity and inorganic nitrate supplementation on the Buckberg ratio in postmenopausal females

Experimental Physiology, EarlyView.
Abstract Menopause increases coronary heart disease risk, in part through reduced oestrogen‐mediated nitric oxide (NO) bioavailability. The Buckberg ratio, an index of myocardial oxygen supply–demand balance, in which higher values reflect more favourable myocardial perfusion, is lower in postmenopausal females (PMFs) than in age‐matched males.
Cassandra C. Derella, Austin C. Hogwood, Joaquin Ortiz de Zevallos, Nathan R. Weeldreyer, Kaitlin M. Love, Arthur Weltman, Jason D. Allen   +6 more
wiley   +1 more source

Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis

, 2017
José Carlos Elias Mouchrek Júnior,1 Cristina Gomes Macedo,2 Henrique Ballassini Abdalla,2 Ana Karina Saba,1 Lucas Novaes Teixeira,1 Adriana Quinzeiro e Silva Mouchrek,3 Marcelo Henrique Napimoga,1 Juliana Trindade Clemente-Napimoga,1 ...
Saba AK, Mouchrek AQES, Mouchrek Júnior JCE, Abdalla HB, Borges AH, Napimoga MH, Tonetto MR, Bandeca MC, Clemente-Napimoga JT, Teixeira LN, Pinto SCS, Martinez EF, Macedo CG   +12 more
core  

Simvastatin protects against cholestasis-induced liver injury.

, 2009
Background: Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. The aim of this study was to evaluate the effect of simvastatin on cholestasis-induced liver inflammation and tissue damage.
Laschke, Matthias,, Menger, M D, H Thorlacius, MW Laschke, Lavasani, Shahram,, S Lavasani, B Jeppsson, Thorlacius, Henrik,, Thorlacius, Henrik, MD Menger, Jeppsson, Bengt, S Dold, Dold, Stefan, Lavasani, Shahram, Dold, Stefan,, Lund University., Laschke, Matthias, Jeppsson, Bengt,   +17 more
core   +1 more source