Results 111 to 120 of about 46,710 (255)

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

open access: yesPeriodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Engineered surface strategies to manage dental implant‐related infections

open access: yesPeriodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza   +7 more
wiley   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

open access: yesPeriodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa   +2 more
wiley   +1 more source

Simvastatin-induced neuroprotective effect after brain injury is mediated by mitochondrial protection through modulation of the 18 ​kDa translocator protein

open access: yesNeurotherapeutics
Traumatic brain injury (TBI) remains a leading cause of mortality and chronic disability. Among therapeutic agents investigated, simvastatin has emerged as a potential therapeutic opportunity for management of TBI although its mechanism of action has not
Reem Sakas   +7 more
doaj   +1 more source

Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis

open access: yes, 2017
José Carlos Elias Mouchrek Júnior,1 Cristina Gomes Macedo,2 Henrique Ballassini Abdalla,2 Ana Karina Saba,1 Lucas Novaes Teixeira,1 Adriana Quinzeiro e Silva Mouchrek,3 Marcelo Henrique Napimoga,1 Juliana Trindade Clemente-Napimoga,1 ...
Saba AK   +12 more
core  

The comparison of simvastatin and atorvastatin efficacy in lowering lipid profile and apolipoprotein-b of diabetic dyslipidemia patient [PDF]

open access: yes, 2013
HMG-CoA reductase inhibitors (Statins) are effective lipid-lowering drugs for the treatment of dyslipidemia patients with type 2diabetes mellitus (T2DM).
Sony Wibisono   +3 more
core  

Simvastatin Attenuates Liver Injury in Rodents with Biliary Cirrhosis Submitted to Hemorrhage/Resuscitation.

open access: yes, 2017
Liver function deterioration is a major cause of death in variceal bleeding. The effects of bleeding on intrahepatic microvascular dysfunction, which contributes to liver injury in cirrhosis, are largely unknown.
Lozano, Juan Jose   +7 more
core   +1 more source

Young People With Type 2 Diabetes Are Under‐Represented in Randomized Clinical Trials

open access: yes
Diabetes, Obesity and Metabolism, EarlyView.
Bowei Yu   +3 more
wiley   +1 more source

Understanding exosomes in regenerative dentistry

open access: yesPeriodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad   +2 more
wiley   +1 more source

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial

open access: yes, 2015
Michelle E John,1 John R Cockcroft,2 Tricia M McKeever,3 William R Coward,1 Dennis J Shale,2 Simon R Johnson,1 Jim G Thornton,4 Timothy W Harrison,1 Alan J Knox,1 Charlotte E Bolton1 1Nottingham Respiratory Research Unit, School of Medicine, University ...
Thornton JG   +9 more
core  

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