Results 101 to 110 of about 93,702 (291)
Synergistic drug combinations from electronic health records and gene expression. [PDF]
, 2016 ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William +19 more
core +2 more sources
Diabetic Medicine, EarlyView.Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye +18 more
wiley +1 more source
The Effect of Simvastatin on Glucose Homeostasis in Streptozotocin Induced Type 2 Diabetic Rats
Journal of Diabetes Research, 2013 Objective. To investigate the effect of simvastatin on glucose homeostasis in streptozotocin induced type 2 diabetic rats. Methods. Forty male Wistar rats were randomly divided into four groups.
Lulu Wang +6 more
doaj +1 more source
Drug-drug interactions in repeat prescriptions at village dispensaries (bereg) in Malta [PDF]
, 2013 Inappropriate treatments and drug-drug interactions (DDIs) are known to occur in settings where repeat prescriptions are issued. In view of this, a study was carried out to document any such problematic drug prescribing and propose changes that would
Bugeja, Anton
core
Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy. [PDF]
, 2016 Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle ...
core +2 more sources
Hepatology Research, EarlyView.ABSTRACT Aim The aim of this all‐case post‐marketing study was to evaluate the real‐world safety and effectiveness in all children and adolescents with chronic hepatitis C with or without compensated cirrhosis treated with glecaprevir/pibrentasvir (G/P) in Japan. Methods This prospective, observational post‐marketing surveillance study was conducted at
Tatsuki Mizuochi +6 more
wiley +1 more source
Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]
, 2015 Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core +1 more source
Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk
International Endodontic Journal, EarlyView.ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar +4 more
wiley +1 more source
Mutations in the _SC4MOL_ gene encoding a novel methyl sterol oxidase cause autosomal recessive psoriasisiform dermatitis, microcephaly and developmental delay [PDF]
, 2008 Disorders of cholesterol biosynthesis have clinical manifestations involving skeleton, eyes, neurologic development, and skin. We describe a patient with congenital cataracts, developmental delay, microcephaly, and low serum cholesterol who developed ...
Abbe Vallejo +8 more
core +1 more source