Results 131 to 140 of about 50,616 (252)

Simvastatin disrupts the RhoA pathway.

, 2016
The Rho/Rho-associated kinase pathway activity is elevated in endothelial monolayers with increased matrix stiffness but is attenuated with 10 μM simvastatin treatment.
John Huynh (704557), Cynthia A. Reinhart-King (218276), Courtney J. Faber (845610), Marsha C. Lampi (845609), Matthew R. Zanotelli (845611), Francois Bordeleau (5666464)   +5 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model

, 2017
Jiawei Sun,1,* Jie Bao,2,* Yanan Shi,3 Bin Zhang,4 Lindong Yuan,5 Junhong Li,1 Lihai Zhang,1 Mo Sun,6 Ling Zhang,2 Wuzhuang Sun1 1Department of Respiratory Medicine, First Hospital of Hebei Medical University, 2Department of Respiratory Medicine, Chest ...
Sun M, Li J, Bao J, Yuan L, Zhang L, Sun W, Zhang B, Sun J, Shi Y   +8 more
core  

Simvastatin effects on androgens, inflammatory mediators, and endogenous pituitary gonadotropins among patients with PCOS undergoing IVF: results from a prospective, randomized, placebo-controlled clinical trial

, 2011
OBJECTIVE: To evaluate effects of simvastatin on selected biochemical parameters and reproductive outcome among patients with polycystic ovary syndrome (PCOS) who undergo in vitro fertilization (IVF).
Tehraninejad, E., Sills, E.S., Rashidi, B.H., Rahmanpour, H., Abediasl, J.   +4 more
core  

Study on the in Vivo Cholesterol‐Lowering Effect of Galacto‐Oligosaccharides Synergized with Lactiplantibacillus plantarum BF_15 via Modulation of Gut Microbiota

Food Frontiers, Volume 7, Issue 5, September 2026.
The synbiotic consisting of galacto oligosaccharides (GOS) and Lactiplantibacillus plantarum BF_15 mitigates hypercholesterolemia in high cholesterol diet fed mice. This synbiotic lowers serum TC, TG, and LDL C levels and ameliorates hepatic steatosis. It enriches gut microbes with bile salt hydrolase activity (e.g., Bifidobacterium) and SCFA producing
Na Zhang, Xinyi Ge, Aixin Guo, Hongjie Liu, Dongyao Li, Chen Li, Hongyan Kang, Miaoshu Wang, Hongtao Tian, Xiaoyan Miao   +9 more
wiley   +1 more source

Cardiovascular Diseases: Exploring Epidemiology, Pathophysiology, Risk Factors, and Medicinal Plant‐Based Therapies: A Narrative Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam, Umme Halima Mithila, Sadia Alam Tisha, Hridoy Saha, Ayesha Binte Mahbub, Farhan Nizam, Johirul Islam, Noushin Tabasumma, Md. Mazharul Islam Chowdhury   +8 more
wiley   +1 more source

Volumetric Microsampling for Patient‐Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Accurate drug concentration measurement is essential for precision pharmacotherapy, but conventional therapeutic drug monitoring (TDM) requires venous sampling, increasing patient burden, and potentially limiting participation in TDM and model‐informed precision dosing (MIPD).
Hari Prabhath Tummala, Abbie D. Leino, Nathaniel J. Rhodes, Kevin J. Downes, Marc H. Scheetz, Manjunath P. Pai   +5 more
wiley   +1 more source

Sustained Release and Therapeutic Evaluation of Simvastatin‐Loaded Bioglass–Chitosan Gel Formulation for Skin Regeneration and Wound Healing Potential

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
A multifunctional chitosan–gallic acid hydrogel incorporated with heparin modified Zn–Ag doped bioglass and simvastatin was synthesized for chronic wound healing. The system shows antioxidant, antimicrobial, and pro‐angiogenic properties, promoting cell proliferation and collagen production.
Durgesh Kumar, Suhela Tyeb, Baby Shruit Shukla, Vivek Verma, Nitesh Kumar   +4 more
wiley   +1 more source

Achieving lipid goals with rosuvastatin compared with simvastatin in high risk patients in real clinical practice: a randomized, open-label, parallel-group, multi-center study: the DISCOVERY-Beta study

, 2008
Toivo Laks1, Ester Keba2, Mariann Leiner3, Eero Merilind4, Mall Petersen5, Sirje Reinmets6, Sille Väli7, Terje Sööt8, Karin Otter81Clinic of Internal Medicine, North-Estonia Regional Hospital, Tallinn, Estonia; 2Clinic of Internal Medicine,
Ester Keba, Eero Merilind, Mall Petersen, Toivo Laks, et al, Mariann Leiner   +5 more
core  

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source