Results 131 to 140 of about 46,710 (255)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Combination of calcium sulfate and simvastatin-controlled release microspheres enhances bone repair in critical-sized rat calvarial bone defects

, 2015
Yin-Chih Fu,1–4 Yan-Hsiung Wang,1,5 Chung-Hwan Chen,1,3,4 Chih-Kuang Wang,1,6 Gwo-Jaw Wang,1,3,4 Mei-Ling Ho1,3,7,8 1Orthopaedic Research Center, 2Graduate Institute of Medicine, 3Department of Orthopaedics, 4Department of Orthopaedics, College of ...
Wang GJ, Ho ML, Wang CK, Fu YC, Chen CH, Wang YH   +5 more
core  

Simvastatin protects against cholestasis-induced liver injury.

, 2009
Background: Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. The aim of this study was to evaluate the effect of simvastatin on cholestasis-induced liver inflammation and tissue damage.
Laschke, Matthias,, Menger, M D, H Thorlacius, MW Laschke, Lavasani, Shahram,, S Lavasani, B Jeppsson, Thorlacius, Henrik,, Thorlacius, Henrik, MD Menger, Jeppsson, Bengt, S Dold, Dold, Stefan, Lavasani, Shahram, Dold, Stefan,, Lund University., Laschke, Matthias, Jeppsson, Bengt,   +17 more
core   +1 more source

Pyruvate Kinase M2 Mediates Apigenin‐Induced Energy Crisis and Apoptosis in Colon Cancer Cells

Food Frontiers, Volume 7, Issue 4, July 2026.
Apigenin, a dietary flavonoid with low toxicity, induces profound bioenergetic collapse in colon cancer cells by downregulating PKM2. This metabolic crisis, characterized by suppressed glycolysis and mitochondrial dysfunction, ultimately triggers robust apoptosis.
Ke Zhang, Xingtao Zhou, Xujie Wang, Mingyong Xie   +3 more
wiley   +1 more source

Simvastatin effects on androgens, inflammatory mediators, and endogenous pituitary gonadotropins among patients with PCOS undergoing IVF: results from a prospective, randomized, placebo-controlled clinical trial

, 2011
OBJECTIVE: To evaluate effects of simvastatin on selected biochemical parameters and reproductive outcome among patients with polycystic ovary syndrome (PCOS) who undergo in vitro fertilization (IVF).
Tehraninejad, E., Sills, E.S., Rashidi, B.H., Rahmanpour, H., Abediasl, J.   +4 more
core  

Simvastatin disrupts the RhoA pathway.

, 2016
The Rho/Rho-associated kinase pathway activity is elevated in endothelial monolayers with increased matrix stiffness but is attenuated with 10 μM simvastatin treatment.
John Huynh (704557), Cynthia A. Reinhart-King (218276), Courtney J. Faber (845610), Marsha C. Lampi (845609), Matthew R. Zanotelli (845611), Francois Bordeleau (5666464)   +5 more
core   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia

, 2002
ObjectivesThe purpose of this study was to assess the efficacy and safety of ezetimibe administered with simvastatin in patients with primary hypercholesterolemia.BackgroundDespite the availability of statins, many patients do not achieve lipid targets ...
Suresh, Ramachandran, Davidson, Michael H, Sun, Steven, Lipka, Leslie J, LeBeaut, Alexandre P, Veltri, Enrico P, Bettis, Robert, Melani, Lorenzo, McGarry, Thomas   +8 more
core   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Simvastatin dengan Senyawa Turunan Β-Siklodextrin

This study aims to determine the profile of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives. To determine the level of stability and determine the solubility level of the inclusion complex formed between ...
Cristy, Devina Wahyu Astaning, Mardiyono, Mardiyono, Harmastuti, Nuraini   +2 more
core   +1 more source