Results 171 to 180 of about 46,710 (255)

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Reengineering statin therapy to protect skeletal muscle: nanocarrier strategies for mitigating mitochondrial dysfunction and myotoxicity. [PDF]

Inflamm Regen
Alabrahim OAA, Allam NK.
europepmc   +1 more source

A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community‐Based Diabetic Population: Study Design of the TAMIS Trial

Journal of Evaluation in Clinical Practice, Volume 32, Issue 4, June 2026.
ABSTRACT Introduction Cardiovascular and cerebrovascular diseases are projected to expand in the coming decades as the main cause of death. This study outlines the escalating burden of cardiovascular diseases in low‐ and middle‐income countries (LMICs), particularly in Latin America (LA), which is expected to surpass that of other high‐population ...
Renato de Carvalho Barros, Andrea Stephanus, José Antonio Barbosa Filho, Evellyn Mariana, Yasmim Botelho, Thaiene M. M. Severino, Robson Conceição Silva, Lucila de Jesus Almeida, Cristiane Koeche, Bruno Gedeon, Mariana Guimarães Souza de Oliveira, Ana Carolina Augusto, Catarina Ferraz, F. Enzo, Gabriela de Lima, Julia Andrade Ibiapina, Giselle Pinto, Sérgio Henrique Rodolpho Ramalho, Ana Claudia C. Nogueira, Andrei C. Sposito, Alessandra M. Campos‐Staffico, Alexandre Anderson S. M. Soares, Luiz Sérgio F. de Carvalho   +22 more
wiley   +1 more source

Core-shell microneedles Co-loaded with simvastatin and doxycycline for combined anti-infection and osteogenesis in diabetic periodontitis. [PDF]

Mater Today Bio
Zhang S, Zhang W, Wang Y, Yin M, Lu S, Li W, Cheng B.   +6 more
europepmc   +1 more source

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1687-1691, June 2026.
ABSTRACT Background Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged ≥ 80 years remains limited. This study aimed to evaluate the long‐term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older.
Ophir Lavon, Wafaa Hamodi, Sameer Kassem
wiley   +1 more source

ROLE OF STATINS IN CIRRHOTIC PORTAL HYPERTENSION: META-ANALYSIS OF RANDOMIZED STUDIES. [PDF]

Arq Gastroenterol
Moreno MOA, Paz CLDSL, Rodrigues MAN, Andrade ACD, Dezan MGF, Cavalcante LN, Lyra AC.   +6 more
europepmc   +1 more source

Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics

, 2015
Osama AA Ahmed,1,2 Khaled M Hosny,1,3 Majid M Al-Sawahli,1,4 Usama A Fahmy11Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy ...
Hosny KM, Ahmed OA, Fahmy UA, Al-Sawahli MM   +3 more
core  

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan, Ameer Y. Taha, Walter Swardfager   +2 more
wiley   +1 more source

Medulloblastoma response to mevalonate pathway inhibition is independent of p53 status. [PDF]

Biol Direct
Comer C, Edwards C, Caporali S, Lu Y, Butera A, Michod D, Gruber AJ, Amelio I, Niklison-Chirou MV.   +8 more
europepmc   +1 more source

Sprayable asymmetric hydrogel prevents postoperative pleural adhesions via physical and biological dual therapy. [PDF]

Mater Today Bio
Li N, Shao Z, Cheng N, Wang Y, Wu B, Hu B, Wang Q, Dan Y, Zhou Y, Zhu K, Xiao R, Ju C, Wang C, Zheng D.   +13 more
europepmc   +1 more source