Results 161 to 170 of about 46,710 (255)

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Simvastatin Restores Cisplatin Sensitivity by Suppressing the Caveolin-1-Mediated PI3K/AKT Signaling Pathway in Cisplatin-Resistant Cervical Cancer Cells. [PDF]

FASEB J
Zhou Y, Liu H, Pan S, Ruan L, Ruan J, Chen J, Ji H, Zhu X.   +7 more
europepmc   +1 more source

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes, Michiel J. Bakkum, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar   +4 more
wiley   +1 more source

A QbD optimization of a pH-responsive Eudragit S100-chitosan nanoformulation for the co-delivery of pentoxifylline and simvastatin in colorectal cancer therapy. [PDF]

RSC Adv
Mahgoub SM, Hamed SM, Allam AA, R I Abdel-Gawad D, Soliman AG, Metwally K, Mahmoud R.   +6 more
europepmc   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

Simvastatin in liver diseases: therapeutic value and research advances. [PDF]

Clin Exp Med
Zhang H, Xu L, Cui Y, Gou W, Li J.
europepmc   +1 more source

Statin-loaded carbonated hydroxyapatite nanoemulsion controls matrix metalloproteinase-1 activity to enhance post-orthodontic stability in rats. [PDF]

J Appl Oral Sci
Alhasyimi AA, Rosyida NF, Pudyani PS.
europepmc   +1 more source

Effect of simvastatin on Staphylococcus aureus biofilm

, 2013
Staphylococcus aureus biofilm is responsible for two-thirds of infections resulting from surgical implants. Simvastatin is a statin drug used to reduce low-density lipoprotein cholesterol levels, but has been shown to inhibit S. aureus invasion into host
Cordero, Diana
core  

The Recruitment and Retention of Individuals With Intellectual Disability in Randomized Controlled Trials: A Scoping Review

British Journal of Learning Disabilities, Volume 54, Issue 2, Page 171-211, June 2026.
ABSTRACT Background People with intellectual disabilities face significant health disparities and often encounter barriers in accessing healthcare services. Although research supports the need for reasonable adjustments to improve healthcare access for this population, implementation in acute healthcare settings remains limited.
Owen Doody, Louise Murphy, Ruth Ryan, Rosemary Lyons, Wenyi Tang, Lorna Bourke   +5 more
wiley   +1 more source

Genistein and Resveratrol: Inhibitors of Kv1.3 Channels in Cancer Cells. [PDF]

Membranes (Basel)
Teisseyre A, Uryga A, Środa-Pomianek K, Palko-Labuz A.   +3 more
europepmc   +1 more source