Results 61 to 70 of about 82,322 (223)

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Efficacy of sacubitril/valsartan sodium combined with simvastatin in treating chronic heart failure with arrhythmia and its effects on IL-6, IL-8, and TNF-α [PDF]

Journal of Medical Biochemistry
Background: To explore, in conjunction with clinical practice, the efficacy of different pharmacological treatment regimens for patients with chronic heart failure complicated by arrhythmia, and their effects on inflammatory factor levels.
Li Jingjing, Wang Zhihua
doaj   +1 more source

Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression

Biomedicines, 2020
Several studies showed an increased risk for diabetes with statin treatment. PGC-1α is an important regulator of muscle energy metabolism and mitochondrial biogenesis.
Miljenko Valentin Panajatovic, François Singh, Stephan Krähenbühl, Jamal Bouitbir   +3 more
doaj   +1 more source

Blood cholesterol levels of hypercholesterolemic rat (Rattus norvegicus) after VCO treatment [PDF]

, 2009
Abstrak. Harini M, Astirin OP. 2009. Kadar kolesterol darah tikus putih (Rattus norvegicus) hiperkolesterolemik setelah perlakuan VCO. Nusantara Bioscience 1: 53-58.
ASTIRIN, OKID PARAMA, HARINI, MARTI
core   +2 more sources

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials [PDF]

, 2010
Background: Lowering of LDL cholesterol with standard statin regimens reduces the risk of occlusive vascular events in a wide range of individuals. We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin ...
Alsheikh-Ali, Ara, Armitage, Athyros, Ben-Yehuda, Cannon, Cannon, Chen, Colhoun, Davidson, Davidson, de Lemos, Downs, Fellstrom, Goldstein, Grundy, Holdaas, Iso, Kjekshus, Knopp, Koren, LaRosa, Nakamura, Pedersen, Pedersen, Ridker, Ridker, Sacks, Serruys, Sever, Shepherd, Shepherd, Stamler, Wanner   +33 more
core   +2 more sources

Neurodevelopmental and Psychiatric Studies in Children and Adolescents With Neurofibromatosis Type I: A Comprehensive Scoping Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A comprehensive synthesis of the broad range of neurodevelopmental and psychiatric manifestations in NF1 is needed to identify knowledge gaps and future directions for NF1 research. In the following scoping review, we identify and summarize the scope of research that examines neurodevelopmental and psychiatric manifestations, both as ...
Meera Chopra, Tin‐Suet Joan Lee, Jacob Vorstman, Patricia Parkin, Louise Gallagher, Aneta Krakowski   +5 more
wiley   +1 more source

The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies. [PDF]

PLoS ONE, 2008
BackgroundCurrent guidelines encourage the use of statins to reduce the risk of cardiovascular disease in diabetic patients; however the impact of these drugs on diabetic retinopathy is not well defined.
Reinhold J Medina, Christina L O'Neill, Adrian B Devine, Tom A Gardiner, Alan W Stitt   +4 more
doaj   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

Simvastatin-loaded liposomal nanoparticles as treatment for adenomyosis in a patient-derived xenograft mouse model: a pilot study

Journal of Obstetrics and Gynaecology
Background Adenomyosis is a common gynaecological condition where ectopic endometrial glands and stroma grow within the myometrium. This condition has a high clinical burden impacting those afflicted with debilitating symptoms including heavy painful ...
Rachel Michel, Kathleen L. Vincent, Gregory W. Kirschen, Massoud Motamedi, Jamal Saada, Jinping Yang, Bulent Ozpolat, Gokhan S. Kilic, Mostafa A. Borahay   +8 more
doaj   +1 more source

Preparation and Characterization of Simvastatin Loaded PLGA Microparticles forTissue Engineering Applications [PDF]

, 2012
Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity. The successful use of simvastatin to promote in vivo bone formation depends on the local concentration, and there have been continuous efforts to find an ...
Ciardelli, Gianluca, Daly, Jacqueline, Montevecchi, Franco M, Muttu, Clara, Nandagiri, Vijay K, Ramtoola, Ziebun   +5 more
core   +1 more source