Results 101 to 110 of about 22,215 (261)

Antiviral Properties of ISG15 [PDF]

, 2010
The type I interferon system plays a critical role in limiting the spread of viral infection. Viruses induce the production of interferon (IFN), which after binding to the IFN-α/β receptor (IFNAR), and triggering of the JAK/STAT signaling cascade ...
Lenschow, Deborah J.
core   +4 more sources

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, Volume 15, Issue 7, Page 1079-1089, July 2025.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Establishment of a New Real-Time Molecular Assay for the Detection of Babanki Virus in Africa

Viruses
Babanki virus is a subtype of the Sindbis virus, a widespread arthropod-borne alphavirus circulating in Eurasia, Africa, and Oceania. Characterized by rashes and arthritis, clinical infections due to Sindbis were mainly reported in Africa, Australia ...
Martin Faye, Mathilde Ban, Fatou Kiné Top, El Hadji Ndiaye, Fatou Diène Thiaw, Gamou Fall, Moussa Moise Diagne, Amadou Alpha Sall, Mawlouth Diallo, Valérie Choumet, Ousmane Faye   +10 more
doaj   +1 more source

Mosquitoborne Sindbis Virus Infection and Long-Term Illness

Emerging Infectious Diseases, 2018
An unexpected human outbreak of the mosquitoborne Sindbis virus occurred in a previously nonendemic area of Sweden. At follow-up, 6–8 months after infection, 39% of patients had chronic arthralgia that affected their daily activities.
Åsa Gylfe, Åsa Ribers, Oscar Forsman, Göran Bucht, Gerd-Marie Alenius, Solveig Wållberg-Jonsson, Clas Ahlm, Magnus Evander   +7 more
doaj   +1 more source

Abundance, Diversity and Phenology of Mosquito Larvae in a Highly Anthropized Wetland: Health and Management Implications of Gándaras de Budiño (NW Spain)

Ecology and Evolution, Volume 15, Issue 7, July 2025.
The natural and anthropized wetland of Gándaras de Budiño (Galicia, Spain) hosts a great number of mosquito species. Culex pipiens s.l. and Culex torrentium pose an emerging risk for West Nile virus transmission. The temporary and polluted waters, as well as the summer and spring seasons, favor the larval proliferation of these vectors.
Yasmina Martínez‐Barciela, Alejandro Polina, Josefina Garrido   +2 more
wiley   +1 more source

Multiplexing FSCV and iGluSnFR3 Sensors Reveals Adenosine Transiently Inhibits Stimulated Dopamine and Glutamate Release

Journal of Neurochemistry, Volume 169, Issue 7, July 2025.
This study highlights the innovative application of multiplexing fast‐scan cyclic voltammetry (FSCV) and genetically encoded fluorescence sensors to simultaneously monitor interactions among adenosine, dopamine, and glutamate with high temporal and spatial resolution.
Kailash Shrestha, Yuanyu Chang, Yajun Zhang, B. Jill Venton   +3 more
wiley   +1 more source

Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens

Virology Journal, 2006
Summary We previously reported evidence of West Nile virus (WNV) circulation in UK birds, probably introduced by migratory birds from overseas. We now demonstrate WNV-specific seroconversion in sentinel chickens raised on an English farm.
Dawson Alistair, Buckley Alan, Gould Ernest A   +2 more
doaj   +1 more source

Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]

, 2015
Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K., Fraser, Robert J., Gunn, Bronwyn M., Heise, Mark T., Herrero, Lara J., Hueston, Linda, Mahalingam, Suresh, Morrison, Thomas E., Ramirez, Ruben, Smith, Paul N., Whitmore, Alan C.   +10 more
core   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source

The alphaviruses: gene expression, replication, and evolution [PDF]

, 1994
The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
core   +1 more source