Results 31 to 40 of about 13,177 (216)

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response [PDF]

, 2009
The double-stranded RNA-activated protein kinase (PKR) is a key regulator of protein translation, interferon (IFN) expression and cell survival. Upon infection of vertebrate cells in continuous culture, the alphavirus Semliki Forest virus (SFV) initiates
Fragkoudis, R., Kohl, A., Rodriguez-Andres, J., Kohl, Alain, Breakwell, L, Barry, G, Fazakerley, J.K., Breakwell, Lucy, Attarzadeh-Yazdi, G., Kohl, A, Barry, Gerald, Fazakerley, John K, Attarzadeh-Yazdi, G, Fazakerley, JK, Fragkoudis, R, Barry, G., Attarzadeh-Yazdi, Ghassem, Rodriguez-Andres, J, Breakwell, L., Rodriguez-Andres, Julio, Fragkoudis, Rennos   +20 more
core   +1 more source

A survey of mosquito-borne and insect-specific viruses in hospitals and livestock markets in western Kenya.

PLoS ONE, 2021
Aedes aegypti and Culex pipiens complex mosquitoes are prolific vectors of arboviruses that are a global threat to human and animal health. Increased globalization and ease of travel have facilitated the worldwide dissemination of these mosquitoes and ...
Tatenda Chiuya, Daniel K Masiga, Laura C Falzon, Armanda D S Bastos, Eric M Fèvre, Jandouwe Villinger   +5 more
doaj   +1 more source

Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells [PDF]

, 2011
Background: Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian ...
Geertsema, C (Corinne), Corinne Geertsema, van Oers, MM, Paulina Andrade, Heldens, J.G.M., Geertsema, C., Vlak Just M, Pijlman Gorben P, Andrade, Paulina, Vlak, J.M. (Just), Vlak, J.M., Pijlman, G.P. (Gorben), Just M Vlak, Metz Stefan W, Goldbach, RW, Metz, S.W. (Stefan), Martina, B.E.E. (Byron), Geertsema Corinne, Metz, S.W.H., Stefan W Metz, Jacco G Heldens, Geertsema, C. (Corinne), Heldens Jacco G, Martina, Byron, Andrade, P. (Paulina), Metz, SW, Andrade Paulina, Heldens, J., Rob W Goldbach, Pijlman, G.P., Pijlman, GP, van Oers Monique M, Oers, M.M. (Monique) van, van Oers, M.M., Andrade, P, Goldbach, R.W., Gorben P Pijlman, Monique M van Oers, Vlak, JM, Goldbach Rob W, Heldens, JG, Byron E Martina, Martina, Byron E., Martina Byron E, Oers, M.M., van   +44 more
core   +1 more source

Glycoprotein is enough for sindbis virus-derived DNA vector to express heterogenous genes

Virology Journal, 2011
To investigate the necessity and potential application of structural genes for expressing heterogenous genes from Sindbis virus-derived vector, the DNA-based expression vector pVaXJ was constructed by placing the recombinant genome of sindbis-like virus ...
Fu Juanjuan, Li Jia, Wang Huanqin, Tang Li, Li Jiangjiao, Zhu Wuyang, Liang Guodong   +6 more
doaj   +1 more source

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source

A novel system for the launch of alphavirus RNA synthesis reveals a role for the Imd pathway in arthropod antiviral response.

PLoS Pathogens, 2009
Alphaviruses are RNA viruses transmitted between vertebrate hosts by arthropod vectors, primarily mosquitoes. How arthropods counteract alphaviruses or viruses per se is not very well understood.
Vasanthi Avadhanula, Brandon P Weasner, Gail G Hardy, Justin P Kumar, Richard W Hardy   +4 more
doaj   +1 more source

Infectious alphavirus production from a simple plasmid transfection+

Virology Journal, 2011
We have developed a new method for producing infectious double subgenomic alphaviruses from plasmids transfected into mammalian cells. A double subgenomic Sindbis virus (TE3'2J) was transcribed from a cytomegalovirus PolII promoter, which results in the ...
Olson Ken E, Lama Siddhi BC, Henderson Brittney R, Steel J Jordan, Geiss Brian J   +4 more
doaj   +1 more source

Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death.

PLoS ONE, 2012
The metabolic resources crucial for viral replication are provided by the host. Details of the mechanisms by which viruses interact with host metabolism, altering and recruiting high free-energy molecules for their own replication, remain unknown ...
Leandro Silva da Costa, Ana Paula Pereira da Silva, Andrea T Da Poian, Tatiana El-Bacha   +3 more
doaj   +1 more source

Homologous Interference Induced by Sindbis Virus [PDF]

Journal of Virology, 1974
Homologous interference during Sindbis virus infection has been investigated. Prior infection of either chicken embryo fibroblast or BHK 21 cell cultures results in reduced yields of progeny virions of the superinfecting genotype.
R E, Johnston, K, Wan, H R, Bose
openaire   +2 more sources

Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts

Virology Journal, 2010
We have recently demonstrated an essential role of the domain of 145-150 amino acid in the E2 glycoprotein of Sindbis virus in the interaction with cellular heparan sulfate (HS) and in the infection of mouse embryonic fibroblasts (MEF) cells.
Zhu Wuyang, Fu Shihong, He Ying, Li Jinping, Liang Guodong   +4 more
doaj   +1 more source