Results 51 to 60 of about 20,013 (221)

Sindbis and Middelburg Old World Alphaviruses Associated with Neurologic Disease in Horses, South Africa

Emerging Infectious Diseases, 2015
Old World alphaviruses were identified in 52 of 623 horses with febrile or neurologic disease in South Africa. Five of 8 Sindbis virus infections were mild; 2 of 3 fatal cases involved co-infections.
Stephanie van Niekerk, Stacey Human, June Williams, Erna van Wilpe, Marthi Pretorius, Robert Swanepoel, Marietjie Venter   +6 more
doaj   +1 more source

Genetic determinants of Sindbis virus neuroinvasiveness [PDF]

Journal of Virology, 1997
After peripheral inoculation of mice, Sindbis virus replicates in a variety of tissues, leading to viremia. In some cases, the virus can enter the central nervous system (CNS) and cause lethal encephalitis. The outcome of infection is age and virus strain dependent.
J, Dubuisson, S, Lustig, N, Ruggli, Y, Akov, C M, Rice   +4 more
openaire   +2 more sources

Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions [PDF]

, 1985
We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the thymidine kinase gene of the vaccinia virus genome.
Franke, Christine A., Hruby, Dennis E., Rice, Charles M., Strauss, James H.   +3 more
core  

The selectivity and specificity of autophagy in drosophila [PDF]

, 2012
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Chou, Clark, Contamine, Deng, Dezelee, Finley, Fouillet, Goto, Kadandale, McPhee, Midorikawa, Nezis, Nisoli, Novak, Orvedahl, Pankiv, Park, Rello-Varona, Schweers, Shoji, Simonsen, Tian, Webb, Wild, Wyers, Yu, Yu, Ziviani   +27 more
core   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis. [PDF]

, 1998
Recent studies have established cell type- specific, proapoptotic, or antiapoptotic functions for the transcription factor NF-kappaB. In each of these studies, inhibitors of NF-kappaB activity have been present before the apoptotic stimulus, and so the ...
DiDonato, JA, Hardwick, JM, Hoffmann, A, Lin, KI, Ratan, RR   +4 more
core  

Small RNA analysis in Sindbis virus infected human HEK293 cells [PDF]

, 2013
In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate.
A Chakrabarti, A Mortazavi, A Saumet, Andras Donaszi-Ivanov, BC Ho, BR Cullen, BR tenOever, CL Campbell, CM Cirimotich, CW Burke, E Gottwein, EG Strauss, EM Morazzani, ER Mardis, EY Choy, F Ma, F Weber, G Gatto, G Szittya, I Mohorianu, I Mohorianu, IP Greene, Irina Mohorianu, J Fang, JI Henke, JK Ahluwalia, JR Abend, JY Leung, K Prufer, KJ Ishii, KL McKnight, KM Myles, KW Witwer, L Du, M Hariharan, MB Stocks, MC Saleh, ML Metzker, MP Gantier, N Vodovar, P Parameswaran, Penny P. Powell, PV Maillard, RL Pilcher, RL Skalsky, RP Kincaid, RW Williams, S Griffiths-Jones, S Koyama, S Moxon, SW Ding, T Kawai, Tamas Dalmay, V Stollar, W Hou, WB Klimstra, X Lei, Y Kim, Y Li, YQ Wu, Zach N. Adelman, ZN Adelman   +61 more
core   +3 more sources

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions [PDF]

, 1989
Sindbis virus mutant ts103 is aberrant in the assembly of virus particles. During virus budding, proper nucleocapsid-glycoprotein interactions fail to occur such that particles containing many nucleocapsids are formed, and the final yield of virus is low.
Hahn, Chang S., Lenches, Edith M., Rice, Charles M., Strauss, Ellen G., Strauss, James H.   +4 more
core  

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source