Results 51 to 60 of about 1,047,175 (209)
Old World alphaviruses were identified in 52 of 623 horses with febrile or neurologic disease in South Africa. Five of 8 Sindbis virus infections were mild; 2 of 3 fatal cases involved co-infections.
Stephanie van Niekerk +6 more
doaj +1 more source
Crimean–Congo hemorrhagic fever virus (CCHFV) infrequently causes hemorrhagic fever in humans with a case fatality rate of 30%. Currently, there is neither an internationally approved antiviral drug nor a vaccine against the virus.
Thomas Tipih +2 more
doaj +1 more source
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding +13 more
wiley +1 more source
Genetic determinants of Sindbis virus neuroinvasiveness [PDF]
After peripheral inoculation of mice, Sindbis virus replicates in a variety of tissues, leading to viremia. In some cases, the virus can enter the central nervous system (CNS) and cause lethal encephalitis. The outcome of infection is age and virus strain dependent.
J, Dubuisson +4 more
openaire +2 more sources
Molecular characterization of a receptor for the Togavirus Sindbis virus [PDF]
The first step in any virus entry process is binding to the plasma membrane of the host cell. The nature of this obligatory step depends upon both the viral and cellular components and may be quite diverse among viruses. The entry of Sindbis virus into a
Wang, Kang-Sheng
core +1 more source
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis +9 more
wiley +1 more source
Recombination between Sindbis virus RNAs [PDF]
The genome (49S RNA) of Sindbis virus is a positive-strand RNA of 11.7 kb that consists of two domains. The 5' two-thirds of the RNA codes for the proteins required for replication and transcription of the RNA. The 3' one-third codes for the structural proteins.
B G, Weiss, S, Schlesinger
openaire +3 more sources
Infection of cells by Sindbis virus at low temperature [PDF]
Sindbis virus, which belongs to the family Togaviridae genus Alphavirus infects a variety of vertebrate and invertebrate cells. The initial steps of Sindbis virus infection involve attachment, penetration and uncoating.
Weninger, Keith +3 more
core +1 more source
We developed sensitive real‐time PCR assays for West Nile virus and Usutu virus to screen bird and human samples in Finland. Although no positive samples were detected, active migratory flyways and recent cases in neighbouring countries highlight the risk of future introduction and the need for continued surveillance.
Ruut Joensuu +6 more
wiley +1 more source
Studies on the Infection of Animal Cells with Sindbis Virus: Adsorption, Cell Surface Modification, and Maturation [PDF]
NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. The surface replica technique was used to study the distribution of Sindbis virus receptors on chick embryo fibroblasts.
Birdwell, Charles Ray
core +1 more source

