Automated single-cell motility analysis on a chip using lensfree microscopy. [PDF]
, 2014 Quantitative cell motility studies are necessary for understanding biophysical processes, developing models for cell locomotion and for drug discovery.
Di Carlo, Dino +6 more
core +1 more source
Nanopipettes as Monitoring Probes for the Single Living Cell: State of the Art and Future Directions in Molecular Biology. [PDF]
, 2018 Examining the behavior of a single cell within its natural environment is valuable for understanding both the biological processes that control the function of cells and how injury or disease lead to pathological change of their function.
Bulbul, Gonca +4 more
core +2 more sources
Laser-fabricated cell patterning stencil for single cell analysis
BMC Biotechnology, 2017 Precise spatial positioning and isolation of mammalian cells is a critical component of many single cell experimental methods and biological engineering applications.
Jacob J. Messner +2 more
doaj +1 more source
Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy. [PDF]
, 2018 The rapid screening and isolation of single leukemia cells from blood has become critical for early leukemia detection and tumor heterogeneity interrogation. However, due to the size overlap between leukemia cells and the more abundant white blood cells (
Digman, Michelle A +4 more
core +1 more source
Transcriptome Analysis of Single Cells [PDF]
Journal of Visualized Experiments, 2011 Many gene expression analysis techniques rely on material isolated from heterogeneous populations of cells from tissue homogenates or cells in culture. In the case of the brain, regions such as the hippocampus contain a complex arrangement of different cell types, each with distinct mRNA profiles.
Morris, Jacqueline +2 more
openaire +2 more sources
A microfluidic processor for gene expression profiling of single human embryonic stem cells [PDF]
, 2008 The gene expression of human embryonic stem cells (hESC) is a critical aspect for understanding the normal and pathological development of human cells and tissues.
Chen, Yan +6 more
core +1 more source
mLife, 2022 Identification, sorting, and sequencing of individual cells directly from in situ samples have great potential for in‐depth analysis of the structure and function of microbiomes.
Zhidian Diao +15 more
doaj +1 more source
Micro/Nanofluidic Devices for Single Cell Analysis
Micromachines, 2014 The Special Issue of Micromachines entitled “Micro/Nanofluidic Devices for Single Cell Analysis” covers recent advancements regarding the analysis of single cells by different microfluidic approaches.
Tuhin Subhra Santra, Fan Gang Tseng
doaj +1 more source
Single cell transcriptome analysis using next generation sequencing. [PDF]
, 2010 The heterogeneity of tissues, especially in cancer research, is a central issue in transcriptome analysis. In recent years, research has primarily focused on the development of methods for single cell analysis. Single cell analysis aims at gaining (novel)
Blattner, M.
core +1 more source
Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures. [PDF]
, 2014 Telomerase is a reverse transcriptase that maintains telomeres on the ends of chromosomes, allowing rapidly dividing cells to proliferate while avoiding senescence and apoptosis.
Hart, Kristina +2 more
core +1 more source