Results 51 to 60 of about 5,714,705 (321)

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Single-cell Motility Analysis of Tethered Human Spermatozoa. [PDF]

, 2019
Vigorous sperm flagellar motility is essential for fertilization, and so the quantitative measurement of motility is a useful tool to assess the intrinsic fertility potential of sperm cells and explore how various factors can alter sperm's ability to ...
Lishko, Polina V, Mannowetz, Nadja, Roan, Nadia R, Skinner, William M   +3 more
core  

Information-theoretic analysis of multivariate single - cell signaling responses using SLEMI

, 2018
Mathematical methods of information theory constitute essential tools to describe how stimuli are encoded in activities of signaling effectors.
Blonski, Slawomir, Jetka, Tomasz, Komorowski, Michal, Nienaltowski, Karol, Winarski, Tomasz   +4 more
core   +1 more source

Chemical analysis of a single basic cell of porous anodic aluminium oxide templates [PDF]

, 2010
We prepared anodic aluminium oxide (AAO) templates with “honeycomb” geometry, i.e. hexagonally ordered circular pores. The structures were extensively studied and characterized by EPMA coupled with FEG-SEM and FEG-TEM coupled with EDX at meso and ...
Arurault, Laurent, Datas, Lucien, Le Coz, François   +2 more
core   +2 more sources

Imaging cell lineage with a synthetic digital recording system [PDF]

, 2020
Cell lineage plays a pivotal role in cell fate determination. Chow et al. demonstrate the use of an integrase-based synthetic barcode system called intMEMOIR, which uses the serine integrase Bxb1 to perform irreversible nucleotide edits.
Budde, Mark W., Cabrera, Maria, Cai, Long, Cho, Soomin, Chow, Ke-Huan K., Elowitz, Michael B., Frieda, Kirsten L., Granados, Alejandro A., Huang, Ting-hao, Koulena, Noushin, Lois, Carlos, Yoon, Shinae   +11 more
core   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Comparison of spatial transcriptomics technologies using tumor cryosections

Genome Biology
Background Spatial transcriptomics technologies are revolutionizing our understanding of intra-tumor heterogeneity and the tumor microenvironment by revealing single-cell molecular profiles within their spatial tissue context.
Anne Rademacher, Alik Huseynov, Michele Bortolomeazzi, Sina Jasmin Wille, Sabrina Schumacher, Pooja Sant, Denise Keitel, Konstantin Okonechnikov, David R. Ghasemi, Kristian W. Pajtler, Jan-Philipp Mallm, Karsten Rippe   +11 more
doaj   +1 more source

Single-Cell Transcriptomics Bioinformatics and Computational Challenges

Frontiers in Genetics, 2016
The emerging single-cell RNA-Seq (scRNA-Seq) technology holds the promise to revolutionize our understanding of diseases and associated biological processes at an unprecedented resolution.
Lana Garmire, Olivier Bertrand Poirion, Xun Zhu, Travers Ching   +3 more
doaj   +1 more source

Single-cell Co-expression Subnetwork Analysis [PDF]

, 2017
Single-cell transcriptomic data have rapidly become very popular in genomic science. Genomic science also has a long history of using network models to understand the way in which genes work together to carry out specific biological functions.
Bartlett, TE, Diaz, A, Müller, S
core   +4 more sources

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source