Results 51 to 60 of about 2,352,277 (290)

Integration of single-cell multi-omics data by regression analysis on unpaired observations

Genome Biology, 2022
Despite recent developments, it is hard to profile all multi-omics single-cell data modalities on the same cell. Thus, huge amounts of single-cell genomics data of unpaired observations on different cells are generated.
Qiuyue Yuan, Zhana Duren
doaj   +1 more source

Single-Cell Gene Expression Analysis: Implications for Neurodegenerative and Neuropsychiatric Disorders [PDF]

Neurochemical Research, 2004
Technical and experimental advances in microaspiration techniques, RNA amplification, quantitative real-time polymerase chain reaction (qPCR), and cDNA microarray analysis have led to an increase in the number of studies of single-cell gene expression.
Stephen D, Ginsberg, Irina, Elarova, Marc, Ruben, Fengzhu, Tan, Scott E, Counts, James H, Eberwine, John Q, Trojanowski, Scott E, Hemby, Elliott J, Mufson, Shaoli, Che   +9 more
openaire   +2 more sources

Missing Value Imputation With Low-Rank Matrix Completion in Single-Cell RNA-Seq Data by Considering Cell Heterogeneity

Frontiers in Genetics, 2022
Single-cell RNA-sequencing (scRNA-seq) technologies enable the measurements of gene expressions in individual cells, which is helpful for exploring cancer heterogeneity and precision medicine.
Meng Huang, Xiucai Ye, Xiucai Ye, Hongmin Li, Tetsuya Sakurai, Tetsuya Sakurai   +5 more
doaj   +1 more source

Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Characterization of cellular heterogeneity and hierarchy are important tasks in developmental biology and may help overcome drug resistance in treatment of cancer and other diseases. Single-cell technologies provide a powerful tool for detecting rare cell types and cell-fate transition events, whereas traditional gene expression ...
Eugenio Marco, Robert L. Karp, Guoji Guo, Paul Robson, Adam H. Hart, Lorenzo Trippa, Guo-Cheng Yuan   +6 more
openaire   +2 more sources

Computational Approach to Identifying Universal Macrophage Biomarkers. [PDF]

, 2020
Macrophages engulf and digest microbes, cellular debris, and various disease-associated cells throughout the body. Understanding the dynamics of macrophage gene expression is crucial for studying human diseases. As both bulk RNAseq and single cell RNAseq
Dang, Dharanidhar, Das, Soumita, Ghosh, Pradipta, Prince, Lawrence S, Sahoo, Debashis, Taheri, Sahar   +5 more
core   +1 more source

Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures. [PDF]

, 2014
Telomerase is a reverse transcriptase that maintains telomeres on the ends of chromosomes, allowing rapidly dividing cells to proliferate while avoiding senescence and apoptosis.
Hart, Kristina, Mathies, Richard A, Novak, Richard   +2 more
core   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential

, 2020
Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P., Dereka, M., Grosschedl, R., Grün, D., Herman, J., Lupar, E., Ramamoorthy, S.   +6 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Correlating mechanical and gene expression data on the single cell level to investigate metastatic phenotypes

iScience, 2023
Summary: Stiffness has been observed to decrease for many cancer cell types as their metastatic potential increases. Although cell mechanics and metastatic potential are related, the underlying molecular factors associated with these phenotypes remain ...
Katherine M. Young, Congmin Xu, Kelly Ahkee, Roman Mezencev, Steven P. Swingle, Tong Yu, Ava Paikeday, Cathy Kim, John F. McDonald, Peng Qiu, Todd Sulchek   +10 more
doaj   +1 more source