Results 51 to 60 of about 1,731,641 (260)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Developmental and tissue-specific expression of the Q5k gene [PDF]

, 1991
Expression of the Q5k gene was examined by northern blot analysis and polymerase chain reaction (PCR) in the AKR mouse and various cell lines, each of the H-2k haplotype.
Brem, Gottfried, Schwemmle, Sabine, Urban, Manuela B., Baeuerle, Patrick A., Bevec, Dorian, Weiss, Elisabeth H.   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Comparison of normal and pre-eclamptic placental gene expression: a systematic review with meta-analysis [PDF]

, 2016
Pre-eclampsia (PE) is a serious multi-factorial disorder of human pregnancy. It is associated with changes in the expression of placental genes. Recent transcription profiling of placental genes with microarray analyses have offered better opportunities
O Brew, O. Brew (3079515), Sullivan, Mark H.F., Brew, Obed, Sullivan, Mark, FH, M H F Sullivan, Brew, O, Woodman, Anthony, Sullivan, MH, A Woodman, M. H. F. Sullivan (3079518), A. Woodman (3079521), Woodman, A   +12 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dynamic analysis of stochastic transcription cycles [PDF]

, 2011
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses.
Davis, Julian R. E., Harper, Claire V., White, Michael R H, Mullins John J., Finkenstädt Bärbel, Davis, Julian R E, See Profile, Mullins, John J, Semprini Sabrina, John J Mullins, Harper Claire V., Sabrina Semprini, Davis Julian R. E., Finkenstaedt, Baerbel, Michael R H White, Friedrichsen, Soenke, Woodcock, Dan J., Spiller, David G., Rand, David A., Mullins, John J., Harper, Claire V; id_orcid, Spiller, David G.; id_orcid, Bärbel Finkenstädt, Woodcock Dan J., Julian R. E. Davis, Woodcock, Dan J, Spiller, David G, David A Rand, Friedrichsen Sönke, Julian R E Davis, David G. Spiller, Michael R. H. White, Ashall Louise, David A. Rand, Friedrichsen, Sönke, John J. Mullins, Dan J. Woodcock, Rand, D. A. (David A.), Spiller David G., White Michael R. H., White, Michael R. H., Louise Ashall, Sönke Friedrichsen, Semprini, Sabrina, Ashall, Louise, Rand, David A, David G Spiller, David A. R, Finkenstädt, Bärbel, Dan J Woodcock, Rand David A., Claire V. Harper, Claire V Harper   +52 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source