Results 201 to 210 of about 852,844 (264)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation. [PDF]

Sci Rep
Herkner F, Posch M, Bond G, König F.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Compound climate extreme events and associated health impacts: a scoping review. [PDF]

BMC Med
Mathews S, Walker C, Gao K, Madrigano J.
europepmc   +1 more source

Causal Effects on Nonterminal Event Time With Application to Antibiotic Usage and Future Resistance. [PDF]

Stat Med
Zehavi T, Obolski U, Chowers M, Nevo D.
europepmc   +1 more source

Drug- and patient-specific neurological risk profiles of α1-adrenergic blockers: evidence from FAERS and external validation in JADER. [PDF]

Ther Adv Drug Saf
Hai X, Huang L.
europepmc   +1 more source

Effect of a Clinical Decision Support System on Team-Based Clinical Quiz Performance Among Japanese Medical Students: A Pre-Post Pilot Study. [PDF]

J Gen Fam Med
Isoda S, Hashimoto T, Nishizawa T, Sekiya S, Yamanaka S, Misawa M, Watari T, Ueda E, Suzuki T, Tokuda Y.   +9 more
europepmc   +1 more source

Instrumental variable estimation of a hazard ratio for treatment with a waiting time without specifying its dependence on unmeasured confounders: application to a procedural registry. [PDF]

Lifetime Data Anal
MacKenzie TA, Martínez-Camblor P, Chen H, Columbo JA, O'Malley AJ.   +4 more
europepmc   +1 more source