Results 91 to 100 of about 11,947,015 (317)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A Portable, Compact, and Fault-Tolerant Processor for Spaceflight Applications

Aerospace
This paper presents the Goddard RISC-V (GRV) a compact, portable, and highly customizable fault-tolerant 32-bit RISC-V processor, specifically designed for embedded space applications. The design integrates advanced fault-tolerance mechanisms to mitigate
David Guzman-Garcia, Ryan J. Ridley, George Suarez, Salman I. Sheikh, Matthew C. Daehn, Jeffrey J. Dumonthier, Georgia A. de Nolfo, John G. Mitchell   +7 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Propagazione di single-event transients in logiche combinatorie [PDF]

, 2022
Lo scopo di questa trattazione è quello di studiare la propagazione dei SET (Single-Event Transients) in catene di inverter implementate a partire da porte logiche di tipo NOT NOR e NAND, tramite l’ausilio di un simulatore tridimensionale.
Bevilacqua, Andrea
core  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

A single-event transient tolerant bandgap reference utilizing dual-modular-redundant (DMR) technique

Nuclear Engineering and Technology
—Bandgap reference (BG) is a crucial component commonly adopted in analog and mixed-signal systems. BG is vulnerable in space applications, which can lead to signal degradation and even subsequent module failure when subjected to heavy-ion strikes.
Jingtian Liu, Jianyang Wang, Lin Deng, Hongliang Lyu, Dongsheng Wang, Shi Xu, Deng Luo   +6 more
doaj   +1 more source

UPSET: A Comprehensive Probabilistic Single Event Transient Analysis Flow for VLSI Circuits Using Static Timing Analysis

Electronics
The downscaling of VLSI technologies has exacerbated the susceptibility of integrated circuits (ICs) to radiation-induced Single-Event Transients (SETs). This work presents UPSET, a comprehensive and technology-independent EDA framework for probabilistic
C. Georgakidis, Dimitris Valiantzas, Nikolaos Chatzivangelis, Marko Andjelković, Christos P. Sotiriou, Milos Krstic   +5 more
semanticscholar   +1 more source

New methods for evaluating the impact of single event transients in VDSM ICs

, 2002
ISBN: 0769518311This work considers a SET (single event transient) fault simulation technique to evaluate the probability that a transient pulse, born in the combinational logic, may be latched in a storage cell.
Nicolaidis, M., Anghel, Lorena, Alexandrescu, D., L. Anghel, M. Nicolaidis, D. Alexandrescu   +5 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source