Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
From vulnerability to robustness: Radiation-hard isolation for BPR-enabled stacked nanosheet CFETs
Nuclear Engineering and TechnologyThe integration of Buried Power Rail (BPR) and Complementary FET (CFET) technologies is a promising way to improve power efficiency and circuit density in advanced logic devices.
Dongwook Kim +4 more
doaj +1 more source
Microsemi RTG4 Rev C Field Programmable Gate Array Single Event Effects (SEE) Heavy-Ion Test Report [PDF]
, 2019 The goal of this study was to perform an independent investigation of single event destructive and transient susceptibility of the Microsemi RTG4 device. The devices under test were the Microsemi RTG4 field programmable gate array (FPGA) Rev C.
Seidleck, Christina +6 more
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Single Event Multiple Transient Analysis using Satisfiability Modulo Theories [PDF]
, 2019 Due to the radioactive nature of the space environment, the integrated circuits in space suffer from reliability problems. This threat is due to the presence of high energy ionizing particles like cosmic ray neutrons and their interaction with the ...
Nethula, Sowmith
core +1 more source
A Comprehensive Methodology for Soft Error Rate (SER) Reduction in Clock Distribution Network
ChipsSingle Event Transients (SETs) in clock-distribution networks are a major source of soft errors in synchronous systems. We present a practical framework that assesses SET risk early in the design cycle, before layout and parasitics, using a Vulnerability
Jorge Johanny Saenz-Noval +2 more
doaj +1 more source
Analysis of SET Reconvergence and Hardening in the Combinational Circuit Using a SAT-Based Method
IEEE Access, 2018 The reconvergence-phenomenon is common in modern circuit design. It occurs when the signal reconvenes at a certain point through multiple sensitized paths. It affects the soft error estimation and hardening. It is complicated to analyze the reconvergence-
Chang Liu, Long Zhang, Xu He, Yang Guo
doaj +1 more source
Investigation of Single Event Transient Effect in Double-Gate InP-Based HEMT
ECS Journal of Solid State Science and TechnologyAn investigation of single event transient (SET) effect in double-gate InP-based HEMT (DG-HEMT) was conducted by simulations. The effects of different drain voltages (VDS), ion incident positions and angles, linear energy transfer (LET) on SET effect ...
Shu-Xiang Sun +4 more
semanticscholar +1 more source
, 2012 A CMOS inverter in 90 nm CMOS bulk technology was exposed to heavy ion radiation (Au-197) at a micro-beam facility. The targeted inverter occupies an area of 6×3 µm².
Zimmermann, Horst +5 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source