Results 171 to 180 of about 13,685 (259)

Clinical Impact of Angiographic Complications Occurring During Percutaneous Coronary Interventions. [PDF]

Catheter Cardiovasc Interv
Bianchini E, Lunardi M, Casamassima F, Bianchini F, Basile M, Romagnoli E, Aurigemma C, Paraggio L, Fracassi F, Montone RA, Buffon A, Cappannoli L, Ierardi C, Sanna T, Leone AM, Trani C, Burzotta F.   +16 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Advancing the Use of Restorative Practices to Lessen Inequities in Punitive Discipline and Build Safe, Inclusive, and Nurturing Learning Environments for Traumatized Students. [PDF]

Behav Sci (Basel)
Hays C, Yepez Y, Riley H, Herrenkohl TI.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Cell-cell junction gene signatures as subtype-specific prognostic biomarkers in breast cancer. [PDF]

PLoS One
Ishii H, Nishiyama K, Nakahara A, Tamori S, Ohno S, Sasaki K, Akimoto K.   +6 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Evolutionary Analysis of Trehalose Breakdown Pathways. [PDF]

Genome Biol Evol
Muthu G G, Laxman S, Seshasayee ASN.
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Insights Into 'Living Flat': A Qualitative Study of Patients Who Have Mastectomy Without Reconstruction. [PDF]

Psychooncology
Lyons L, Martin C, Wyld L, King N, Brunsden S, Morgan J.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source