Results 81 to 90 of about 258,562 (263)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Single-nucleus RNA (snRNA) sequencing v1

Step-by-step protocol describing the snRNA sequencing workflow for nuclei isolated from post-mortem human brain tissue.
Anita Adami, Raquel Garza
openaire   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Comprehensive sequencing of the lung neuroimmune landscape in response to asthmatic induction

Frontiers in Immunology
IntroductionEvidence demonstrates that sensory neurons respond to pathogenic/allergic infiltration and mediate immune responses, forming an integral part of host defense that becomes hypersensitized during allergy.
Hayden McSwiggin, Rui Wang, Rubens Daniel Miserani Magalhães, Fengli Zhu, Taylor A. Doherty, Wei Yan, Wei Yan, Nicholas Jendzjowsky, Nicholas Jendzjowsky   +8 more
doaj   +1 more source

Single cell atlas for 11 non-model mammals, reptiles and birds

Nature Communications, 2021
Here the authors report single-nucleus RNA sequencing for several anatomical locations in 11 species, including cat, dog, hamster, lizard, goat, rabbit, duck, pigeon, pangolin, tiger, and deer, highlighting coexpression of SARS-CoV-2 entry factors ACE2 ...
Dongsheng Chen, Jian Sun, Jiacheng Zhu, Xiangning Ding, Tianming Lan, Xiran Wang, Weiying Wu, Zhihua Ou, Linnan Zhu, Peiwen Ding, Haoyu Wang, Lihua Luo, Rong Xiang, Xiaoling Wang, Jiaying Qiu, Shiyou Wang, Haimeng Li, Chaochao Chai, Langchao Liang, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Feiyue Wang, Yuting Yuan, Wendi Wu, Chengcheng Sun, Haorong Lu, Jihong Wu, Xinghuai Sun, Shenghai Zhang, Sunil Kumar Sahu, Ping Liu, Jun Xia, Lijing Zhang, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Zehua Cui, Qian He, Sanjie Jiang, Xiaoyan Ma, Weimin Feng, Yan Xu, Fang Li, Zhongmin Liu, Lei Chen, Fang Chen, Xin Jin, Wei Qiu, Tianjiao Wang, Yang Li, Xiumei Xing, Huanming Yang, Yanchun Xu, Yan Hua, Yahong Liu, Huan Liu, Xun Xu   +59 more
doaj   +1 more source

Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing [PDF]

Nature Neuroscience, 2018
In females with X-linked genetic disorders, wild-type and mutant cells coexist within brain tissue because of X-chromosome inactivation, posing challenges for interpreting the effects of X-linked mutant alleles on gene expression. We present a single-nucleus RNA sequencing approach that resolves mosaicism by using single-nucleotide polymorphisms in ...
William Renthal, Lisa D. Boxer, Sinisa Hrvatin, Emmy Li, Andrew Silberfeld, M. Aurel Nagy, Eric C. Griffith, Thomas Vierbuchen, Michael E. Greenberg   +8 more
openaire   +2 more sources

One-two punch mechanism of gene repression: a fresh perspective on gene regulation. [PDF]

, 2017
Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another.
Tresenrider, Amy, Ünal, Elçin
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Meta-analysis of single-cell and single-nucleus transcriptomics reveals kidney cell type consensus signatures

Scientific Data, 2023
While the amount of studies involving single-cell or single-nucleus RNA-sequencing technologies grows exponentially within the biomedical research area, the kidney field requires reference transcriptomic signatures to allocate each cluster its matching ...
Marceau Quatredeniers, Alice S. Serafin, Alexandre Benmerah, Antonio Rausell, Sophie Saunier, Amandine Viau   +5 more
doaj   +1 more source

Complete Sequences of Organelle Genomes from the Medicinal Plant Rhazya Stricta (Apocynaceae) and Contrasting Patterns of Mitochondrial Genome Evolution Across Asterids [PDF]

, 2014
Rhazya stricta is native to arid regions in South Asia and the Middle East and is used extensively in folk medicine to treat a wide range of diseases.
Baeshen, Mohammed N., Baeshen, Nabih A., Jansen, Robert K., Mutwakil, Mohammed H. Z., Park, Seongjun, Ruhlman, Tracey A., Sabir, Jamal S. M., Sabir, Meshaal J.   +7 more
core   +1 more source