Results 1 to 10 of about 1,316,697 (275)

SpeckleNN: a unified embedding for real-time speckle pattern classification in X-ray single-particle imaging with limited labeled examples [PDF]

IUCrJ, 2023
With X-ray free-electron lasers (XFELs), it is possible to determine the three-dimensional structure of noncrystalline nanoscale particles using X-ray single-particle imaging (SPI) techniques at room temperature.
Cong Wang, Eric Florin, Hsing-Yin Chang, Jana Thayer, Chun Hong Yoon   +4 more
doaj   +4 more sources

The linac coherent light source single particle imaging road map [PDF]

Structural Dynamics, 2015
Intense femtosecond x-ray pulses from free-electron laser sources allow the imaging of individual particles in a single shot. Early experiments at the Linac Coherent Light Source (LCLS) have led to rapid progress in the field and, so ...
A. Aquila, A. Barty, C. Bostedt, S. Boutet, G. Carini, D. dePonte, P. Drell, S. Doniach, K. H. Downing, T. Earnest, H. Elmlund, V. Elser, M. Gühr, J. Hajdu, J. Hastings, S. P. Hau-Riege, Z. Huang, E. E. Lattman, F. R. N. C. Maia, S. Marchesini, A. Ourmazd, C. Pellegrini, R. Santra, I. Schlichting, C. Schroer, J. C. H. Spence, I. A. Vartanyants, S. Wakatsuki, W. I. Weis, G. J. Williams   +29 more
doaj   +9 more sources

Effects of radiation damage and inelastic scattering on single-particle imaging of hydrated proteins with an X-ray Free-Electron Laser [PDF]

Scientific Reports, 2021
We present a computational case study of X-ray single-particle imaging of hydrated proteins on an example of 2-Nitrogenase–Iron protein covered with water layers of various thickness, using a start-to-end simulation platform and experimental parameters ...
Juncheng E, Michal Stransky, Zoltan Jurek, Carsten Fortmann-Grote, Libor Juha, Robin Santra, Beata Ziaja, Adrian P. Mancuso   +7 more
doaj   +3 more sources

An advanced workflow for single-particle imaging with the limited data at an X-ray free-electron laser [PDF]

IUCrJ, 2020
An improved analysis for single-particle imaging (SPI) experiments, using the limited data, is presented here. Results are based on a study of bacteriophage PR772 performed at the Atomic, Molecular and Optical Science instrument at the Linac Coherent ...
Dameli Assalauova, Young Yong Kim, Sergey Bobkov, Ruslan Khubbutdinov, Max Rose, Roberto Alvarez, Jakob Andreasson, Eugeniu Balaur, Alice Contreras, Hasan DeMirci, Luca Gelisio, Janos Hajdu, Mark S. Hunter, Ruslan P. Kurta, Haoyuan Li, Matthew McFadden, Reza Nazari, Peter Schwander, Anton Teslyuk, Peter Walter, P. Lourdu Xavier, Chun Hong Yoon, Sahba Zaare, Viacheslav A. Ilyin, Richard A. Kirian, Brenda G. Hogue, Andrew Aquila, Ivan A. Vartanyants   +27 more
doaj   +4 more sources

Single-particle imaging without symmetry constraints at an X-ray free-electron laser [PDF]

IUCrJ, 2018
The analysis of a single-particle imaging (SPI) experiment performed at the AMO beamline at LCLS as part of the SPI initiative is presented here. A workflow for the three-dimensional virus reconstruction of the PR772 bacteriophage from measured single ...
Max Rose, Sergey Bobkov, Kartik Ayyer, Ruslan P. Kurta, Dmitry Dzhigaev, Young Yong Kim, Andrew J. Morgan, Chun Hong Yoon, Daniel Westphal, Johan Bielecki, Jonas A. Sellberg, Garth Williams, Filipe R.N.C. Maia, Olexander M. Yefanov, Vyacheslav Ilyin, Adrian P. Mancuso, Henry N. Chapman, Brenda G. Hogue, Andrew Aquila, Anton Barty, Ivan A. Vartanyants   +20 more
doaj   +3 more sources

Is radiation damage the limiting factor in high-resolution single particle imaging with X-ray free-electron lasers? [PDF]

Structural Dynamics, 2019
The prospect of single particle imaging with atomic resolution is one of the scientific drivers for the development of X-ray free-electron lasers. The assumption since the beginning has been that damage to the sample caused by intense X-ray pulses is one
C. Östlin, N. Timneanu, C. Caleman, A. V. Martin   +3 more
doaj   +3 more sources

Start-to-end simulation of single-particle imaging using ultra-short pulses at the European X-ray Free-Electron Laser [PDF]

IUCrJ, 2017
Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules.
Carsten Fortmann-Grote, Alexey Buzmakov, Zoltan Jurek, Ne-Te Duane Loh, Liubov Samoylova, Robin Santra, Evgeny A. Schneidmiller, Thomas Tschentscher, Sergey Yakubov, Chun Hong Yoon, Michael V. Yurkov, Beata Ziaja-Motyka, Adrian P. Mancuso   +12 more
doaj   +3 more sources

Efficient Lithium-Based Upconversion Nanoparticles for Single-Particle Imaging and Temperature Sensing. [PDF]

Materials (Basel), 2023
Upconversion Nanoparticles (UCNPs) have attracted exceptional attention due to their great potential in high-contrast, free-background biofluorescence deep tissue imaging and quantum sensing. Most of these interesting studies have been performed using an
Alzahrani YA, Alromaeh A, Alkahtani M.
europepmc   +2 more sources

Virus Detection and Identification in Minutes Using Single-Particle Imaging and Deep Learning. [PDF]

ACS Nano, 2023
The increasing frequency and magnitude of viral outbreaks in recent decades, epitomized by the current COVID-19 pandemic, has resulted in an urgent need for rapid and sensitive viral diagnostic methods.
Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C, Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N, Crook DW, Kapanidis AN, Robb NC.   +15 more
europepmc   +2 more sources

Label-free single-particle imaging approach for ultra-rapid detection of pathogenic bacteria in clinical samples. [PDF]

Proc Natl Acad Sci U S A, 2022
Significance Rapid detection of pathogenic bacteria in clinical samples within a few minutes is the key to infectious disease control and precise medicine.
Chen S, Su YW, Sun J, Chen T, Zheng Y, Sui LJ, Yang S, Liu C, Wang P, Li T, Chi Q, Sun H, Chen J, Xu BQ, Huang Z, Fang Y.   +15 more
europepmc   +2 more sources