Results 281 to 290 of about 478,505 (298)

Nanobodies, single-domain antigen-binding fragments of camelid heavy-chain antibodies.

2010
Antibodies or immunoglobulins are glycoproteins produced by B-cells and play a central role in host immune defense. Antibodies can be elicited virtually against any substance. Moreover, the immune response to any given antigen can be diverse, comprising different antibodies exhibiting different affinities and/or epitope specificities.
Hassanzadeh Ghassabeh, Gholamreza, Muyldermans, Serge, Saerens, Dirk   +2 more
openaire   +1 more source

Development of a novel and broadly applicable sandwich ELISA assay based on rabbit single-chain variable fragments and a modified Ig-binding domain of protein L fused to a polystyrene-binding peptide

Journal of Immunological Methods
Most of currently available sandwich-type enzyme-linked immunosorbent assays (ELISA) require the use of full-length animal-derived antibodies which poses welfare criticisms and are often expensive to produce. There is therefore a strong demand for the development of more affordable and animal-free methods to produce antibodies for sandwich ELISA assay.
Yamamoto, Yodai, Taniguchi, Haruka, Nguyen, Ngoc Minh, Yokoyama, Fuki, Choowongkomon, Kiattawee, Angelini, Alessandro, Horiuchi, Jun-Ichi, Kumada, Yoichi   +7 more
openaire   +3 more sources

A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity.

Gene therapy, 1996
The elimination of tumor cells by cytotoxic T lymphocytes (CTLs) could become the basis of a biological cancer therapy. The recognition specificity of cytotoxic T lymphocytes (CTLs) can be genetically modified by stable introduction of chimeric T cell receptor genes and thus be directed towards tumor cells.
D, Moritz, B, Groner
openaire   +1 more source

Backbone and side-chain ¹H, ¹³C and ¹⁵N resonance assignments of the OB domain of the single stranded DNA binding protein from Sulfolobus solfataricus and chemical shift mapping of the DNA-binding interface.

Biomolecular NMR assignments, 2015
Single stranded DNA binding proteins (SSBs) are present in all known cellular organisms and are critical for DNA replication, recombination and repair. The SSB from the hyperthermophilic crenarchaeote Sulfolobus solfataricus (SsoSSB) has an unusual domain structure with a single DNA-binding oligonucleotide binding (OB) fold coupled to a flexible C ...
Roland, Gamsjaeger, Ruvini, Kariawasam, Christine, Touma, Ann H, Kwan, Malcolm F, White, Liza, Cubeddu   +5 more
openaire   +1 more source

Advantages of Single-Domain Antigen-Binding Fragments Derived from Functional Camel Heavy-Chain Antibodied

2001
Muyldermans Serge, Conrath Katja, Vu Khoa Bang, Serrao Teresa, Busch Magnus, Backmann Natasha, Silence Karen, Lauwereys Marc, Desmyter Aline   +8 more
openaire   +1 more source

Single-domain antibodies for biomedical applications

Immunopharmacology and Immunotoxicology, 2016
Simon Krah, Christian Schröter, Stefan Zielonka   +2 more
exaly  

Effect of Domain Order on the Activity of Bacterially Produced Bispecific Single-chain Fv Antibodies

Journal of Molecular Biology, 2003
Sergey M Kipriyanov, Gerhard Moldenhauer, Michael Braunagel   +2 more
exaly  

Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor

Biosensors and Bioelectronics, 2007
Guilherme N M Ferreira, Luis F M Rosa, Sara Barrento   +2 more
exaly  

Camel heavy-chain antibodies: diverse germline VHH and specific mechanisms enlarge the antigen-binding repertoire

EMBO Journal, 2000
Viet Khong Nguyen, Lode Wyns, Serge Muyldermans   +2 more
exaly  

Nanobodies: Natural Single-Domain Antibodies

Annual Review of Biochemistry, 2013
Serge Muyldermans
exaly