Results 161 to 170 of about 737,167 (335)

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

, 1993
Zelig Eshhar, Tova Waks, G. Gross, Daniel Schindler   +3 more
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Llama Single Domain Antibodies Specific for the 7 Botulinum Neurotoxin Serotypes as Heptaplex Immunoreagents

, 2010
Jerry O. Conway, Laura J. Sherwood, M. Thelma Collazo, J.A. Garza, Andrew Hayhurst   +4 more
openalex   +2 more sources

Multimeric single-domain antibody complexes protect against bunyavirus infections

, 2020
Paul J. Wichgers Schreur, Sandra van de Water, Michiel M. Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, S. R. S. S Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard Kristiansen, Kieran K Mistry, Ziyan Deng, Jan Hellert, Pablo Guardado‐Calvo, F.A. Rey, Lucien van Keulen, Jeroen Kortekaas   +20 more
openalex   +1 more source

Supplementary Methods from A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface

, 2023
Zhewei Tang, Mingqian Feng, Wei Gao, Yen Phung, Weizao Chen, Amit Chaudhary, Brad St. Croix, Min Qian, Dimiter S. Dimitrov, Mitchell Ho   +9 more
openalex   +1 more source

Reversal of carbapenem resistance in Pseudomonas aeruginosa by camelid single domain antibody fragment (VHH) against the C4 dicarboxylate transporter [PDF]

, 2023
Anil Kumar Nagraj, Manjiri Shukla, Mansi Kulkarni, Pratik Rajendra Patil, Mrunal Borgave, Sanjiban K Banerjee   +5 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Editorial: Nanobody-based cancer immunotherapy and immunoimaging

Frontiers in Immunology, 2023
Mahdie Jafari, Amirhosein Maali, Mohammad Ali Shokrgozar, Zahra Sharifzadeh   +3 more
doaj   +1 more source

Coupling Single Domain Antibodies to Catalytic Hairpin Assemblies for Homogeneous Assays

Advanced Sensor Research
Immunoassays are widely used in various fields, including biomedical research, clinical diagnostics, and environmental monitoring. Single domain antibodies (sdAbs) provide small, tailorable, recognition elements that have been integrated into ...
Jinny L. Liu, Dan Zabetakis, Lisa C. Shriver‐Lake, George P. Anderson, Ellen R. Goldman, Hieu Bui   +5 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source