Results 141 to 150 of about 1,169,281 (338)

Supplementary Figure from Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177–Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model

, 2023
Thomas Ertveldt, Lien De Beck, Kirsten De Ridder, Hanne Locy, Wout de Mey, Cleo Goyvaerts, Quentin Lecocq, Hannelore Ceuppens, Yannick De Vlaeminck, Robin Maximilian Awad, Marleen Keyaerts, Nick Devoogdt, Matthias D’Huyvetter, Karine Breckpot, Ahmet Krasniqi   +14 more
openalex   +1 more source

Microfluidic multipoles: theory and applications [PDF]

, 2018
Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced ...
Boulais, Étienne, Gervais, Thomas, Goyette, Pierre-Alexandre, Juncker, David, Laberge, Gabriel, Normandeau, Frédéric   +5 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single‐Domain Llama‐Derived Antibody [PDF]

, 2019
Maurits R. Hollander, Matthijs Jansen, Luuk H G A Hopman, Edward Dolk, Peter M. van de Ven, Paul Knaapen, Anton J.G. Horrevoets, Esther Lutgens, Niels van Royen   +8 more
openalex   +1 more source

Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin [PDF]

, 1998
A number of structural and functional subnuclear compartments have been described, including regions exclusive of chromosomes previously hypothesized to form a reactive nuclear space.
Bridger, JM, Herrmann, H, Lichter, P, Muenkel, C   +3 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody.

PLoS ONE, 2014
Single domain antibodies are the small recombinant variable domains derived from camelid heavy-chain-only antibodies. They are renowned for their stability, in large part due to their ability to refold following thermal or chemical denaturation.
Dan Zabetakis, Mark A Olson, George P Anderson, Patricia M Legler, Ellen R Goldman   +4 more
doaj   +1 more source

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site [PDF]

, 2018
Siva Krishna Angalakurthi, David J. Vance, Yinghui Rong, Chi Thành Nguyên, M. Rudolph, David B. Volkin, C. Russell Middaugh, David D. Weis, Nicholas J. Mantis   +8 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity [PDF]

, 2009
Janusz Wesolowski, Vanina Alzogaray, Jan Reyelt, Mandy Unger, Karla Juárez‐Moreno, Mariela Urrutia, Ana Cauerhff, Welbeck Danquah, Björn Rissiek, Felix Scheuplein, Nicole Schwarz, Sahil Adriouch, Olivier Boyer, Michel Séman, Alexei F. Licea-Navarro, David Serreze, Fernando A. Goldbaum, Friedrich Haag, Friedrich Koch‐Nolte   +18 more
openalex   +1 more source