Results 231 to 240 of about 1,169,281 (338)

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

, 2022
Ilia Gelfat, Yousuf Aqeel, Jacqueline M. Tremblay, Justyna J. Jaskiewicz, Anishma Shrestha, James N. Lee, Shenglan Hu, Xi Qian, Loranne Magoun, Abhineet S. Sheoran, Daniela Bedenice, Colter Giem, Avinash Manjula‐Basavanna, Amanda R. Pulsifer, Hann X. Tu, Xiaoli Li, Marilyn L. Minus, Marcia S. Osburne, Saul Tzipori, Charles B. Shoemaker, John M. Leong, Neel Joshi   +21 more
openalex   +1 more source

Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish [PDF]

, 2017
Gao, Meng, Hu, Xuebin, Jiang, Tao, Li, Chang, Liu, Fei, Liu, Jing Yu, Liu, Mugen, Liu, Xiliang, Lu, Zhaojing, Shu, Xinhua, Soares, Dinesh C., Tang, Zhaohui, Weng, Jun, Xiao, Qing, Yang, Lifang, Yu, Shanshan   +15 more
core   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Domain-based assays of individual antibody concentrations in an oligoclonal combination targeting a single protein

, 2011
Qinglai Meng, M. Li, M.A. Silberg, Fraser Conrad, J. D. Bettencourt, R. To, Carol Huang, J. Ma, Kassondra Meyer, Robert M. Shimizu, Liching Cao, Milan T. Tomic, James D. Marks   +12 more
openalex   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

FASTIA: A rapid and accessible platform for protein variant interaction analysis demonstrated with a single-domain antibody. [PDF]

Protein Sci
Matsunaga R, Tsumoto K.
europepmc   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

An anti-idiotypic single domain antibody as Cry2Aa toxin mimotope and analysis of its binding region through molecular docking. [PDF]

BMC Biotechnol
Lin M, Han G, Li C, Huang L, Liu Q, Zhang N, Xia Y, Lu Y, Liu X, Liu Y, Xu J, Lin J.   +11 more
europepmc   +1 more source

Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions. [PDF]

J Immunother Cancer, 2023
Lameris R, Shahine A, Veth M, Westerman B, Godfrey DI, Lutje Hulsik D, Brouwer P, Rossjohn J, de Gruijl TD, van der Vliet HJ.   +9 more
europepmc   +1 more source

Topical delivery of human single-domain antibody targeting IL-33 for inhibiting mucosal inflammation [PDF]

Tianlei Ying, Keke Huang, Yuqing Wu, Yu Kong, Qingyuan Xu, Yirou Zhang, Quanxiao Li, Cheng Li, Wenping Song, Xiaoyi Zhu, Zhenlin Yang, Changchang Xin, Xujiao Zhou, Yanling Wu, Jiaxu Hong   +14 more
openalex   +1 more source