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Characterization of Single-Domain Antibodies with an Engineered Disulfide Bond
2012Camelidae single-domain antibodies (VHHs) represent a unique class of emerging therapeutics. Similar to other recombinant antibody fragments (e.g., Fabs, scFvs), VHHs are amenable to library screening and selection, but benefit from superior intrinsic biophysical properties such as high refolding efficiency, high solubility, no tendency for aggregation,
Hussack, G., MacKenzie, C.R., Tanha, J.
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2006
Classical antibodies are complex assemblies, difficult to produce in bacteria, and too bulky for many medical or research applications. Therefore, substantial efforts aimed at finding simpler miniaturised antibodies. Heavy-chain antibodies in camelids are a natural source of such mini-antibodies. Moreover, their antigen-binding domain (named Nanobody),
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Classical antibodies are complex assemblies, difficult to produce in bacteria, and too bulky for many medical or research applications. Therefore, substantial efforts aimed at finding simpler miniaturised antibodies. Heavy-chain antibodies in camelids are a natural source of such mini-antibodies. Moreover, their antigen-binding domain (named Nanobody),
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[Progress in shark single-domain antibody].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2020Monoclonal antibody (mAb) is an important biological macromolecule and widely used in immune detection, in vitro diagnostics, and drug discovery. However, the inherent properties of mAb restrict its further development, such as high molecular weight and complex structure. Therefore, there is an urgent need to develop alternatives for mAb. Various types
Xing, Liu, Qi, Chen
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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody
Cell, 2022Cheng Li, Wuqiang Zhan, Gaowei Hu
exaly
Nanobody affinity improvement: Directed evolution of the anti-ochratoxin A single domain antibody
International Journal of Biological Macromolecules, 2020Zhichang Sun +2 more
exaly
Single domain antibody-based bispecific antibody induces potent specific anti-tumor activity
Cancer Biology and Therapy, 2016Changhua Zhou, Zhong Wang
exaly