Results 31 to 40 of about 1,169,281 (338)

A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia

Clinical Cancer Research, 2021
Purpose: Although considerable progress has been made with autologous T cell–based therapy in B-cell malignancies, application in chronic lymphocytic leukemia (CLL) lags behind due to disappointing response rates as well as substantial toxicity that is ...
Iris de Weerdt, Roeland Lameris, J. Ruben, Renate de Boer, J.M.E. Kloosterman, L. King, M. Levin, P. Parren, T. D. de Gruijl, A. Kater, H. J. van der Vliet   +10 more
semanticscholar   +1 more source

Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer

Journal for ImmunoTherapy of Cancer, 2021
Background The discovery of checkpoint inhibitors towards cytotoxic T-lymphocyte protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) has been revolutionary for the treatment of cancers.
Tianhang Zhai, Chao Wang, Yifeng Xu, Weifeng Huang, Zhi-zhao Yuan, Tao Wang, Shuang Dai, Shaogang Peng, T. Pang, Wenchao Jiang, Yuhua Huang, Yuefeng Zou, Yingda Xu, Joanne Sun, Xinjiang Gong, Jinping Zhang, Andy Tsun, Bin Li, Xiaoniu Miao   +18 more
semanticscholar   +1 more source

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

Signal Transduction and Targeted Therapy, 2021
The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years. The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer
Zhenlin Yang, Yulu Wang, Yu-jia Jin, Yuanfei Zhu, Yanling Wu, Cheng Li, Yu Kong, Wenping Song, Xiao-long Tian, Wuqiang Zhan, Ailing Huang, Shan Zhou, Shuai Xia, Xiaoxu Tian, Chao Peng, Cuicui Chen, Yi-Qian Shi, Gaowei Hu, Shujuan Du, Yuyan Wang, Youhua Xie, Shibo Jiang, Lu Lu, Lei Sun, Yuanlin Song, T. Ying   +25 more
semanticscholar   +1 more source

Seed-produced anti-globulin VHH-Fc antibodies retrieve globulin precursors in the insoluble fraction and modulate the Arabidopsis thaliana seed subcellular morphology [PDF]

, 2020
Key message Nanobody-heavy chain (VHH-Fc) antibody formats have the potential to immunomodulate even highly accumulating proteins and provide a valuable tool to experimentally modulate the subcellular distribution of seed storage proteins.
Altmann, Friedrich, Arcalis, Elsa, De Meyer, Thomas, Depicker, Anna, Maleux, Katrien, Melnik, Stanislav, Nolf, Jonah, Stöger, Eva   +7 more
core   +2 more sources

PET Imaging of Tumor PD-L1 Expression with a Highly Specific Nonblocking Single-Domain Antibody

Journal of Nuclear Medicine, 2020
Although immunotherapy through programmed death 1/programmed death ligand 1 (PD-1/PD-L1) checkpoint blockade has shown impressive clinical outcomes, not all patients respond to it.
Gaochao Lv, Xiaorong Sun, L. Qiu, Yan Sun, Ke Li, Qingzhu Liu, Qi Zhao, S. Qin, Jianguo Lin   +8 more
semanticscholar   +1 more source

Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model

PLoS Pathogens, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the disease COVID-19 can lead to serious symptoms, such as severe pneumonia, in the elderly and those with underlying medical conditions.
K. Haga, Reiko Takai-Todaka, Yuta Matsumura, Chihong Song, Tomomi Takano, T. Tojo, Atsushi Nagami, Yukiharu Ishida, Hidekazu Masaki, M. Tsuchiya, T. Ebisudani, S. Sugimoto, Toshiro Sato, H. Yasuda, K. Fukunaga, Akihito Sawada, N. Nemoto, K. Murata, T. Morimoto, K. Katayama   +19 more
semanticscholar   +1 more source

Single-Domain Antibody Nuclear Imaging Allows Noninvasive Quantification of LAG-3 Expression by Tumor-Infiltrating Leukocytes and Predicts Response of Immune Checkpoint Blockade

Journal of Nuclear Medicine, 2021
Visual Abstract Recent advances in the field of immune-oncology led to the discovery of next-generation immune checkpoints (ICPs). Lymphocyte activation gene-3 (LAG-3), being the most widely studied among them, is being explored as a target for the ...
Q. Lecocq, R. M. Awad, Y. De Vlaeminck, W. de Mey, T. Ertveldt, C. Goyvaerts, G. Raes, K. Thielemans, M. Keyaerts, N. Devoogdt, K. Breckpot   +10 more
semanticscholar   +1 more source

A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]

, 2019
Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Buratto, Damiano, Carrer, Andrea, Chiani, Francesco, Kuang, Yuanyuan, Lerner, Richard A, Mammano, Fabio, Nardin, Chiara, Paludetti, Gaetano, Salvatore, Anna Maria, Xu, Liang, Yang, Guang, Ziraldo, Gaia, Zonta, Francesco   +12 more
core   +1 more source

Structure of a VHH isolated from a naïve phage display library

BMC Research Notes, 2019
Objective To determine the X-ray structure and biophysical properties of a Camelid VHH isolated from a naïve phage display library. Results Single domain antibodies (VHH) derived from the unique immune system of the Camelidae family have gained traction ...
Brandy White, Ian Huh, Cory L. Brooks
doaj   +1 more source

mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice

Molecular Therapy: Nucleic Acids, 2020
To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past years, optimization of the characteristics of in vitro transcribed mRNA has led to significant ...
Lien Van Hoecke, Rein Verbeke, Dorien De Vlieger, Heleen Dewitte, Kenny Roose, Sharon Van Nevel, Olga Krysko, Claus Bachert, Bert Schepens, Ine Lentacker, Xavier Saelens   +10 more
doaj   +1 more source