Results 41 to 50 of about 1,169,281 (338)

NbX: Machine Learning-Guided Re-Ranking of Nanobody–Antigen Binding Poses

Pharmaceuticals, 2021
Modeling the binding pose of an antibody is a prerequisite to structure-based affinity maturation and design. Without knowing a reliable binding pose, the subsequent structural simulation is largely futile.
Chunlai Tam, Ashutosh Kumar, Kam Y. J. Zhang   +2 more
doaj   +1 more source

Bglbrick strategy for the construction of single domain antibody fusions

Heliyon, 2017
Single domain antibodies, recombinantly expressed variable domains derived from camelid heavy chain antibodies, are often expressed as multimers for detection and therapeutic applications.
Ellen R. Goldman, Aeris Broussard, George P. Anderson, Jinny L. Liu   +3 more
doaj   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Conjugation of biotin-coated luminescent quantum dots with single domain antibody-rhizavidin fusions

Biotechnology Reports, 2016
Straightforward and effective methods are required for the bioconjugation of proteins to surfaces and particles. Previously we demonstrated that the fusion of a single domain antibody with the biotin binding molecule rhizavidin provided a facile method ...
Jinny L. Liu, Scott A. Walper, Kendrick B. Turner, Audrey Brozozog Lee, Igor L. Medintz, Kimihiro Susumu, Eunkeu Oh, Dan Zabetakis, Ellen R. Goldman, George P. Anderson   +9 more
doaj   +1 more source

Biotechnological applications of recombinant single-domain antibody fragments

Microbial Cell Factories, 2011
Background Single-domain antibody fragments possess structural features, such as a small dimension, an elevated stability, and the singularity of recognizing epitopes non-accessible for conventional antibodies that make them interesting for several ...
de Marco Ario
doaj   +1 more source

A common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system [PDF]

, 2008
The M protein of Streptococcus equi subsp. equi known as fibrinogen-binding protein (FgBP) is a cell wall-associated protein with antiphagocytic activity that binds IgG. Recombinant versions of the seven equine IgG subclasses were used to investigate the
Abi-Rached, Berge, Boschwitz, Boschwitz, Bruggemann, Burton, Burton, Carlsson, Deisenhofer, DeLano, Flock, Flock, Galan, Galan, Galan, Ghetie, Harrington, Herr, Jonsson, Lancet, Lewis, Lindmark, Meehan, Meehan, Meehan, Meehan, Meehan, Morton, Newton, Nitsche-Schmitz, Pleass, Pleass, Ramsland, Recht, Sauer-Eriksson, Sheoran, Sheoran, Taylor, Timoney, Timoney, Timoney, van Loghem, Wagner, Wagner, Wagner, Waller, Wines, Wines, Wolbink, Åkerström   +49 more
core   +4 more sources

A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization. [PDF]

J Transl Med
De Leiris N, Perret P, Lombardi C, Gözel B, Chierici S, Millet P, Debiossat M, Bacot S, Tournier BB, Chames P, Lenormand JL, Ghezzi C, Fagret D, Moulin M.   +13 more
europepmc   +3 more sources

Antibody fragments as probe in biosensor development [PDF]

, 2008
Today's proteomic analyses are generating increasing numbers of biomarkers, making it essential to possess highly specific probes able to recognize those targets.
Bonroy, Kristien, Huang, Lieven, Muyldermans, Serge, Saerens, Dirk   +3 more
core   +3 more sources

Increased Tumor Penetration of Single-Domain Antibody Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models.

Cancer Research, 2020
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA approved antibody-drug conjugates (ADCs).
I. Nessler, Eshita Khera, S. Vance, Anna Kopp, Qifeng Qiu, T. Keating, A. Abu-Yousif, T. Sandal, J. Legg, Lorraine H Thompson, Normann Goodwin, Greg M. Thurber   +11 more
semanticscholar   +1 more source

DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]

, 2009
Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core   +2 more sources