Results 101 to 110 of about 211,032 (253)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

SEU Rate and Reliability Analysis in LEO Satellites [PDF]

فصلنامه علوم و فناوری فضایی, 2012
Due to high design and launch cost of satellites, their failure probability should be minimized. Single Event Effects (SEUs) are one of the most common error sources in satellite microelectronic. To cope with these unwanted errors, various techniques are
Reza Omidi Gosheblagh, Karim Mohammadi
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Measurement of the 1-jettiness event shape observable in deep-inelastic electron-proton scattering at HERA

European Physical Journal C: Particles and Fields
The H1 Collaboration reports the first measurement of the 1-jettiness event shape observable $$\tau _1^b$$ τ 1 b in neutral-current deep-inelastic electron-proton scattering (DIS).
H1 Collaboration, V. Andreev, M. Arratia, A. Baghdasaryan, A. Baty, K. Begzsuren, A. Bolz, V. Boudry, G. Brandt, D. Britzger, A. Buniatyan, L. Bystritskaya, A. J. Campbell, K. B. Cantun Avila, K. Cerny, V. Chekelian, Z. Chen, J. G. Contreras, J. Cvach, J. B. Dainton, K. Daum, A. Deshpande, C. Diaconu, A. Drees, G. Eckerlin, S. Egli, E. Elsen, L. Favart, A. Fedotov, J. Feltesse, M. Fleischer, A. Fomenko, C. Gal, J. Gayler, L. Goerlich, N. Gogitidze, M. Gouzevitch, C. Grab, T. Greenshaw, G. Grindhammer, D. Haidt, R. C. W. Henderson, J. Hessler, J. Hladký, D. Hoffmann, R. Horisberger, T. Hreus, F. Huber, P. M. Jacobs, M. Jacquet, T. Janssen, A. W. Jung, J. Katzy, C. Kiesling, M. Klein, C. Kleinwort, H. T. Klest, S. Kluth, R. Kogler, P. Kostka, J. Kretzschmar, D. Krücker, K. Krüger, M. P. J. Landon, W. Lange, P. Laycock, S. H. Lee, S. Levonian, W. Li, J. Lin, K. Lipka, B. List, J. List, B. Lobodzinski, O. R. Long, E. Malinovski, H.-U. Martyn, S. J. Maxfield, A. Mehta, A. B. Meyer, J. Meyer, S. Mikocki, V. M. Mikuni, M. M. Mondal, K. Müller, B. Nachman, Th. Naumann, P. R. Newman, C. Niebuhr, G. Nowak, J. E. Olsson, D. Ozerov, S. Park, C. Pascaud, G. D. Patel, E. Perez, A. Petrukhin, I. Picuric, D. Pitzl, R. Polifka, S. Preins, V. Radescu, N. Raicevic, T. Ravdandorj, D. Reichelt, P. Reimer, E. Rizvi, P. Robmann, R. Roosen, A. Rostovtsev, M. Rotaru, D. P. C. Sankey, M. Sauter, E. Sauvan, S. Schmitt, B. A. Schmookler, G. Schnell, L. Schoeffel, A. Schöning, S. Schumann, F. Sefkow, S. Shushkevich, Y. Soloviev, P. Sopicki, D. South, A. Specka, M. Steder, B. Stella, L. Stöcker, U. Straumann, C. Sun, T. Sykora, P. D. Thompson, F. Torales Acosta, D. Traynor, B. Tseepeldorj, Z. Tu, G. Tustin, A. Valkárová, C. Vallée, P. van Mechelen, D. Wegener, E. Wünsch, J. Žáček, J. Zhang, Z. Zhang, R. Žlebčík, H. Zohrabyan, F. Zomer   +148 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source