Results 31 to 40 of about 4,194 (248)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Fiber-based mode converter for generating optical vortex beams

open access: yesOpto-Electronic Advances, 2018
In this work, an all-fiber-based mode converter for generating orbital angular momentum (OAM) beams is proposed and numerically investigated. Its structure is constructed by cascading a mode selective coupler (MSC) and an inner elliptical cladding fiber (
Chen Ruishan   +5 more
doaj   +1 more source

Geometric Progression of Optical Vortices

open access: yesPhotonics, 2022
We study coaxial superpositions of Gaussian optical vortices described by a geometric progression. The topological charge (TC) is obtained for all variants of such superpositions. The TC can be either integer or half-integer in the initial plane. However,
Victor Kotlyar   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Complex optical solutions and modulation instability of hyperbolic Schrödinger dynamical equation

open access: yesResults in Physics, 2019
Complex hyperbolic Schrödinger equation describes ultra-short pulse propagation in nonlinear media fiber optics. In this paper, new complex solutions for the complex hyperbolic Schrödinger equation are constructed using generalized elliptic equation ...
Wilson Osafo Apeanti   +2 more
doaj   +1 more source

Correlation Optics, Coherence and Optical Singularities: Basic Concepts and Practical Applications

open access: yesFrontiers in Physics, 2022
The main idea of this review is to trace the interrelations and inter-transitions between the basic concepts and approaches of the correlation optics (including the light coherence) and the singular optics dealing with networks of “exceptional” points of
O. V. Angelsky   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Orbital angular momentum of the spiral beams [PDF]

open access: yesКомпьютерная оптика, 2019
At first sight, any rotation generates some angular momentum (it is true for a solid body). But these characteristics (rotation and orbital angular momentum) are rather different for optics and mechanics.
Vladimir Volostnikov
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Dynamics of Fractional Vortex Beams at Fraunhofer Diffraction Zone

open access: yesPhotonics, 2022
Fractional vortex beams (FVBs) possess unique topological properties that are manifested in the vortex distribution. However, there are still discrepancies in the value of the vortex strength of FVBs at the far field.
Eduardo Peters   +3 more
doaj   +1 more source

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