Results 41 to 50 of about 61,868 (235)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Singular-phase nanooptics: towards label-free single molecule detection

, 2013
Non-trivial topology of phase is crucial for many important physics phenomena such as, for example, the Aharonov-Bohm effect 1 and the Berry phase 2. Light phase allows one to create "twisted" photons 3, 4 , vortex knots 5, dislocations 6 which has led ...
Ansell, D., Britnell, L., Geim, A. K., Gorbachev, R. V., Grigorenko, A. N., Jalil, R., Kabashin, A. V., Kravets, V. G., Novoselov, K. S., Schedin, F., Thackray, B.   +10 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Singularities of Partially Polarized Vortex Beams

Frontiers in Physics, 2020
Singularities in the polarization state of non-uniform electromagnetic beams have been a topic of both theoretical and practical interest for many years, as have singularities in the correlation functions of random scalar wavefields.
William Scott Raburn, Greg Gbur
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Fiber-based mode converter for generating optical vortex beams

Opto-Electronic Advances, 2018
In this work, an all-fiber-based mode converter for generating orbital angular momentum (OAM) beams is proposed and numerically investigated. Its structure is constructed by cascading a mode selective coupler (MSC) and an inner elliptical cladding fiber (
Chen Ruishan, Wang Jinghao, Zhang Xiaoqiang, Yao Junna, Ming Hai, Wang Anting   +5 more
doaj   +1 more source

Generation and Propagation of Partially Coherent Power-Exponent-Phase Vortex Beam

Frontiers in Physics, 2021
We report on a partially coherent power-exponent-phase vortex beam (PC-PEPV), whose spatial coherence is controllable and the initial phase exhibits a periodic power exponential change.
Hao Zhang, Xingyuan Lu, Zhuoyi Wang, A. P. Konijnenberg, Haiyun Wang, Chengliang Zhao, Yangjian Cai, Yangjian Cai, Yangjian Cai   +8 more
doaj   +1 more source

Reflections on Gibbs: From Statistical Physics to the Amistad [PDF]

, 2014
This note is based upon a talk given at a celebration in Austin Texas of the achievements of J. Willard Gibbs. J. Willard Gibbs, the younger, was the first American physical sciences theorist. He was one of the inventors of statistical physics.
Kadanoff, Leo P.
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Complex optical solutions and modulation instability of hyperbolic Schrödinger dynamical equation

Results in Physics, 2019
Complex hyperbolic Schrödinger equation describes ultra-short pulse propagation in nonlinear media fiber optics. In this paper, new complex solutions for the complex hyperbolic Schrödinger equation are constructed using generalized elliptic equation ...
Wilson Osafo Apeanti, Aly R. Seadawy, Dianchen Lu   +2 more
doaj   +1 more source