Results 1 to 10 of about 1,311,541 (283)
Genetic Complexity of Sinoatrial Node Dysfunction [PDF]
Frontiers in Genetics, 2021 The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace +16 more
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Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]
PLoS ONE, 2017 Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck +8 more
doaj +7 more sources
Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis. [PDF]
Circulation, 2022 Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and ...
Zheng M +14 more
europepmc +2 more sources
Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
Journal of Cardiovascular Development and Disease, 2021 Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small proportion of the total mass of the heart yet must produce a stimulus of ...
Marietta Easterling +3 more
doaj +2 more sources
Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]
Fayixue Zazhi, 2021 Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
doaj +3 more sources
Frontiers in Physiology, 2020 The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat.
Eilidh A. MacDonald +3 more
doaj +2 more sources
Nature Communications, 2020 The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their ...
Ning Li +20 more
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Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
Nature Communications, 2021 The spontaneous bioelectrical activity of pacemaker cells in sinoatrial node (SAN) triggers the heartbeats. Here, the authors perform single-cell RNA sequencing in the mouse SAN and identify molecular and cellular features of the SAN conserved in rabbit ...
Dandan Liang +15 more
doaj +2 more sources
Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [PDF]
Nature CommunicationsThe sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not ...
Amos A. Lim +14 more
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JAMA Oncol, 2022 Importance Atrial fibrillation (AF) can develop following thoracic irradiation. However, the critical cardiac substructure responsible for AF has not been properly studied.
Kim KH +13 more
europepmc +2 more sources