Results 1 to 10 of about 58,493 (121)

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [PDF]

open access: yesNature Communications
The sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not ...
Amos A. Lim   +14 more
doaj   +2 more sources

Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model [PDF]

open access: yesFrontiers in Physiology
Background: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels ...
Eugenio Ricci   +4 more
doaj   +2 more sources

Genetics of sinoatrial node function and heart rate disorders

open access: yesDisease Models & Mechanisms, 2023
Lieve E. van der Maarel   +2 more
doaj   +2 more sources

Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]

open access: yesFayixue Zazhi, 2021
Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
doaj   +1 more source

Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis

open access: yesJournal of Cardiovascular Development and Disease, 2021
Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small proportion of the total mass of the heart yet must produce a stimulus of ...
Marietta Easterling   +3 more
doaj   +1 more source

Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics. [PDF]

open access: yesPLoS ONE, 2014
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium.
Patric Glynn, Birce Onal, Thomas J Hund
doaj   +1 more source

Junctional Pacemaker May Replace the Sinoatrial Node

open access: yesCardiovascular Innovations and Applications, 2021
Junctional rhythm is usually seen in the clinic with different causes. We report a case of bicuspid aortic valve accompanied by sinoatrial node dysfunction.
Min Lin   +4 more
doaj   +1 more source

Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]

open access: yesPLoS ONE, 2017
Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck   +8 more
doaj   +1 more source

Anatomopathological changes in canine distemper seropositive dogs and virus detection in sinoatrial nodes

open access: yesBioscience Journal, 2020
Canine distemper is a viral disease that affects several systems on dogs, among them, the cardiovascular system. The aim of this study was to identify canine distemper virus (CDV) in the sinoatrial node (SAN) of dogs serologically positive for distemper
José Eugenio Diniz Bastos   +4 more
doaj   +3 more sources

T-wave Inversion through Inhomogeneous Voltage Diffusion within the FK3V Cardiac Model [PDF]

open access: yesChaos 34, 043140 (2024), 2023
The heart beats due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart's electrical system. A large body of work is devoted to modeling the propagation of the action potential and to reproducing reliably ...
arxiv   +1 more source

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