Results 1 to 10 of about 20,135 (157)

Function and dysfunction of human sinoatrial node [PDF]

Korean Circulation Journal, 2015
Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release).
Chen, Peng-Sheng, Joung, Boyoung
core   +5 more sources

Pharmacologic Approach to Sinoatrial Node Dysfunction

Annual Review of Pharmacology and Toxicology, 2021
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Pietro Mesirca, Vadim V Fedorov, Thomas J Hund   +2 more
exaly   +5 more sources

Molecular Pathway for the Localized Formation of the Sinoatrial Node [PDF]

Circulation Research, 2007
The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been defined.
Mathilda T M Mommersteeg, Willem M H Hoogaars, Virginia E Papaioannou   +2 more
exaly   +3 more sources

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways [PDF]

Progress in Biophysics and Molecular Biology, 2016
Despite a century of extensive study on the human sinoatrial node (SAN), the structure-to-function features of specialized SAN conduction pathways (SACP) are still unknown and debated. We report a new method for direct analysis of the SAN microstructure in optically-mapped human hearts with and without clinical history of SAN dysfunction.Two explanted ...
Jichao Zhao, Brian J Hansen, Ning Li
exaly   +4 more sources

Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF. [PDF]

JACC Clin Electrophysiol
Manning D, Rivera EJ, Rhana P, Matsumoto C, Fong Z, Thai PN, Muñoz MF, Contreras JE, Kim S, Grainger N, Chiamvimonvat N, Bautista GM, Santana LF.   +12 more
europepmc   +2 more sources

Sinoatrial-Node Entrance Block [PDF]

Circulation, 1971
Sinus-node function was characterized in 13 patients during cardiac catheterization by the introduction of progressively premature atrial depolarizations. Curves relating the extent of sinus-node depression following these premature depolarizations and their degree of prematurity were constructed.
B N, Goldreyer, A N, Damato
openaire   +2 more sources

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases [PDF]

, 2020
Aims The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge.
Asano, Yoshihiro, Beerens, Manu, Burch, Micah L, Buys, Eva, Chiang, David Y, Cui, Shihe, Fujino, Noboru, Fujita, Takashi, Funada, Akira, Furusho, Hiroshi, Hayashi, Kenshi, Hodatsu, Akihiko, Inoue, Masaru, Kaku, Bunji, Kato, Takeshi, Kawashiri, Masa-aki, Kelly, Amy E, Kita, Yoshihito, Kiviniemi, Tuomas O, Kobayashi, Isao, Konno, Tetsuo, Kurata, Yasutaka, MacRae, Calum A, Nagata, Yoji, Nakanishi, Chiaki, Namura, Masanobu, Nomura, Akihiro, Oe, Kotaro, Okada, Hirofumi, Onoue, Kenji, Saito, Yoshihiko, Sakamoto, Yuichiro, Sakata, Kenji, Sips, Patrick, Tada, Hayato, Takamura, Masayuki, Takashima, Seiji, Takeda, Yuko, Tanaka, Yoshihiro, Teramoto, Ryota, Tsuchiya, Taketsugu, Tsuda, Toyonobu, Usuda, Keiich, Yamagishi, Masakazu, Zhao, Yanbin   +44 more
core   +1 more source

Genetic Complexity of Sinoatrial Node Dysfunction [PDF]

Frontiers in Genetics, 2021
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is associated with impaired pacemaker function causing abnormal heart rhythm.
Michael J. Wallace, Michael J. Wallace, Michael J. Wallace, Mona El Refaey, Mona El Refaey, Mona El Refaey, Pietro Mesirca, Pietro Mesirca, Thomas J. Hund, Thomas J. Hund, Thomas J. Hund, Matteo E. Mangoni, Matteo E. Mangoni, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler   +16 more
openaire   +3 more sources

Telocytes in the human sinoatrial node [PDF]

Journal of Cellular and Molecular Medicine, 2017
AbstractThe sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells. We hypothesize that the SAN contains telocytes that have contacts with pacemaker cells and contractile ...
Lubov B. Mitrofanova, Andrey N. Gorshkov, Petr V. Konovalov, Julia S. Krylova   +3 more
openaire   +2 more sources

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating [PDF]

, 2011
We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal ...
Markhasin, V. S., Moskvin, A. S., Ryvkin, A. M., Solovyova, O. E.   +3 more
core   +3 more sources