Results 1 to 10 of about 22,194 (282)

Genetic Complexity of Sinoatrial Node Dysfunction [PDF]

Frontiers in Genetics, 2021
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace, Michael J. Wallace, Michael J. Wallace, Mona El Refaey, Mona El Refaey, Mona El Refaey, Pietro Mesirca, Pietro Mesirca, Thomas J. Hund, Thomas J. Hund, Thomas J. Hund, Matteo E. Mangoni, Matteo E. Mangoni, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler   +16 more
doaj   +3 more sources

Computer modelling of the sinoatrial node [PDF]

Medical & Biological Engineering & Computing, 2007
Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential.
Ronald Wilders
openalex   +6 more sources

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [PDF]

Nature Communications
The sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not ...
Amos A. Lim, Delaram Pouyabahar, Mishal Ashraf, Kate Huang, Michelle Lohbihler, Brandon M. Murareanu, Matthew L. Chang, Maggie Kwan, Faisal J. Alibhai, Thinh Tran, Amine Mazine, Michael A. Laflamme, Gary D. Bader, Zachary Laksman, Stephanie Protze   +14 more
doaj   +2 more sources

Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model [PDF]

Frontiers in Physiology
Background: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels ...
Eugenio Ricci, Fazeelat Mazhar, Moreno Marzolla, Stefano Severi, Chiara Bartolucci   +4 more
doaj   +2 more sources

Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis. [PDF]

Circulation, 2022
Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and function.
Zheng M, Li RG, Song J, Zhao X, Tang L, Erhardt S, Chen W, Nguyen BH, Li X, Li M, Wang J, Evans SM, Christoffels VM, Li N, Wang J.   +14 more
europepmc   +3 more sources

Emerging Signaling Regulation of Sinoatrial Node Dysfunction. [PDF]

Curr Cardiol Rep, 2023
The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Zheng M, Erhardt S, Cao Y, Wang J.
europepmc   +3 more sources

Sinoatrial node arteriosclerosis in two young dogs [PDF]

Journal of the American Veterinary Medical Association, 1994
Two 11-month-old 7-kg unrelated female Beagles had clinical signs referable to the cardiovascular system. Histologic studies in both dogs revealed strikingly similar findings of sclerosis of the arteries of the sinoatrial node. Histologic changes included intimal thickening and fibrosis, with marked luminal narrowing; medial hypertrophy, fibrosis, and ...
Heidi J. Hamlen, Steven A. Kargas, Joanne R. Blum   +2 more
openalex   +3 more sources

CaMKII in sinoatrial node physiology and dysfunction

Frontiers in Pharmacology, 2014
The calcium and calmodulin dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological fight or flight SAN beating rate responses.
Yuejin eWu, Mark E Anderson, Mark E Anderson   +2 more
doaj   +3 more sources

Atypical form of sinoatrial node reentrant tachycardia: Should the traditional diagnostic criteria be modified? [PDF]

HeartRhythm Case Reports
Shin Sakai, MD, Mitsunori Maruyama, MD, PhD, FHRS, Eiichiro Oka, MD, PhD, Kuniya Asai, MD, PhD   +3 more
doaj   +2 more sources

Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]

Fayixue Zazhi, 2021
Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
doaj   +1 more source