Results 1 to 10 of about 9,868 (113)

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [PDF]

Nature Communications
The sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not ...
Amos A. Lim, Delaram Pouyabahar, Mishal Ashraf, Kate Huang, Michelle Lohbihler, Brandon M. Murareanu, Matthew L. Chang, Maggie Kwan, Faisal J. Alibhai, Thinh Tran, Amine Mazine, Michael A. Laflamme, Gary D. Bader, Zachary Laksman, Stephanie Protze   +14 more
doaj   +2 more sources

Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report [PDF]

Frontiers in Cardiovascular Medicine
Pulmonary vein pulsed-field ablation (PFA) is widely regarded as a safe procedure for patients with atrial fibrillation (AF), with sinoatrial disturbances as a rare complication. A 62-year-old female patient with paroxysmal AF underwent ablation using an
Enyuan Zhang, Enyuan Zhang, Le He, Henan Zhang, Jing Xu, Fengmin Lu, Dongyan Wu, Yitong Yin, Wei Ma   +8 more
doaj   +2 more sources

Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model [PDF]

Frontiers in Physiology
Background: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels ...
Eugenio Ricci, Fazeelat Mazhar, Moreno Marzolla, Stefano Severi, Chiara Bartolucci   +4 more
doaj   +2 more sources

Atypical form of sinoatrial node reentrant tachycardia: Should the traditional diagnostic criteria be modified? [PDF]

HeartRhythm Case Reports
Shin Sakai, MD, Mitsunori Maruyama, MD, PhD, FHRS, Eiichiro Oka, MD, PhD, Kuniya Asai, MD, PhD   +3 more
doaj   +2 more sources

Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]

Fayixue Zazhi, 2021
Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
doaj   +1 more source

Genetics of sinoatrial node function and heart rate disorders

Disease Models & Mechanisms, 2023
Lieve E. van der Maarel, Alex V. Postma, Vincent M. Christoffels   +2 more
doaj   +2 more sources

Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis

Journal of Cardiovascular Development and Disease, 2021
Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small proportion of the total mass of the heart yet must produce a stimulus of ...
Marietta Easterling, Simone Rossi, Anthony J Mazzella, Michael Bressan   +3 more
doaj   +1 more source

Translational Anatomy of the Sinoatrial Node [PDF]

JACC: Case Reports
Alejandro Jiménez Restrepo, MD, Mansour Razminia, MD, Damián Sánchez-Quintana, MD, PhD, José-Ángel Cabrera Rodriguez, MD, PhD   +3 more
doaj   +2 more sources

Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics. [PDF]

PLoS ONE, 2014
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium.
Patric Glynn, Birce Onal, Thomas J Hund
doaj   +1 more source

Junctional Pacemaker May Replace the Sinoatrial Node

Cardiovascular Innovations and Applications, 2021
Junctional rhythm is usually seen in the clinic with different causes. We report a case of bicuspid aortic valve accompanied by sinoatrial node dysfunction.
Min Lin, Yuqin Xiong, Yipin Lin, Yuhua Li, Lijuan Zhang   +4 more
doaj   +1 more source