Results 1 to 10 of about 22,373 (266)

Genetic Complexity of Sinoatrial Node Dysfunction [PDF]

Frontiers in Genetics, 2021
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace, Michael J. Wallace, Michael J. Wallace, Mona El Refaey, Mona El Refaey, Mona El Refaey, Pietro Mesirca, Pietro Mesirca, Thomas J. Hund, Thomas J. Hund, Thomas J. Hund, Matteo E. Mangoni, Matteo E. Mangoni, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler   +16 more
doaj   +3 more sources

Computer modelling of the sinoatrial node [PDF]

Medical & Biological Engineering & Computing, 2007
Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential.
Ronald Wilders
openalex   +6 more sources

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [PDF]

Nature Communications
The sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not ...
Amos A. Lim, Delaram Pouyabahar, Mishal Ashraf, Kate Huang, Michelle Lohbihler, Brandon M. Murareanu, Matthew L. Chang, Maggie Kwan, Faisal J. Alibhai, Thinh Tran, Amine Mazine, Michael A. Laflamme, Gary D. Bader, Zachary Laksman, Stephanie Protze   +14 more
doaj   +2 more sources

Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report [PDF]

Frontiers in Cardiovascular Medicine
Pulmonary vein pulsed-field ablation (PFA) is widely regarded as a safe procedure for patients with atrial fibrillation (AF), with sinoatrial disturbances as a rare complication. A 62-year-old female patient with paroxysmal AF underwent ablation using an
Enyuan Zhang, Enyuan Zhang, Le He, Henan Zhang, Jing Xu, Fengmin Lu, Dongyan Wu, Yitong Yin, Wei Ma   +8 more
doaj   +2 more sources

Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model [PDF]

Frontiers in Physiology
Background: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels ...
Eugenio Ricci, Fazeelat Mazhar, Moreno Marzolla, Stefano Severi, Chiara Bartolucci   +4 more
doaj   +2 more sources

Function and dysfunction of human sinoatrial node [PDF]

Korean Circulation Journal, 2015
Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release).
Chen, Peng-Sheng, Joung, Boyoung
core   +5 more sources

Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis. [PDF]

Circulation, 2022
Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and function.
Zheng M, Li RG, Song J, Zhao X, Tang L, Erhardt S, Chen W, Nguyen BH, Li X, Li M, Wang J, Evans SM, Christoffels VM, Li N, Wang J.   +14 more
europepmc   +3 more sources

Emerging Signaling Regulation of Sinoatrial Node Dysfunction. [PDF]

Curr Cardiol Rep, 2023
The sinoatrial node (SAN), the natural pacemaker of the heart, is responsible for generating electrical impulses and initiating each heartbeat. Sinoatrial node dysfunction (SND) causes various arrhythmias such as sinus arrest, SAN block, and tachycardia/bradycardia syndrome.
Zheng M, Erhardt S, Cao Y, Wang J.
europepmc   +3 more sources

The Evolution of Sinoatrial Node Function in Man [PDF]

, 1973
The function of the sinoatrial node is complex. In nearly all hearts, this small bit of tissue is responsible for spontaneously generating the impulse which will be distributed to the remainder of the heart, maintaining coordinated electrical and ...
Bigger, J. Thomas, Strauss, Harold C.
core   +3 more sources

Sinoatrial node arteriosclerosis in two young dogs [PDF]

Journal of the American Veterinary Medical Association, 1994
Two 11-month-old 7-kg unrelated female Beagles had clinical signs referable to the cardiovascular system. Histologic studies in both dogs revealed strikingly similar findings of sclerosis of the arteries of the sinoatrial node. Histologic changes included intimal thickening and fibrosis, with marked luminal narrowing; medial hypertrophy, fibrosis, and ...
Heidi J. Hamlen, Steven A. Kargas, Joanne R. Blum   +2 more
openalex   +3 more sources