Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [PDF]
Nature CommunicationsThe sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not ...
Amos A. Lim +14 more
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Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]
PLoS ONE, 2017 Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck +8 more
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Sinoatrial node heterogeneity and fibroblasts increase atrial driving capability in a two-dimensional human computational model [PDF]
Frontiers in PhysiologyBackground: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels ...
Eugenio Ricci +4 more
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Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node. [PDF]
Front Med (Lausanne)Jorge Tasé DA +3 more
europepmc +3 more sources
Mechanistic insight into the functional role of human sinoatrial node conduction pathways and pacemaker compartments heterogeneity: A computer model analysis. [PDF]
PLoS Comput Biol, 2023 Zhao J +7 more
europepmc +2 more sources
Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]
Fayixue Zazhi, 2021 Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
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Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF. [PDF]
JACC Clin ElectrophysiolManning D +12 more
europepmc +2 more sources
Genetics of sinoatrial node function and heart rate disorders
Disease Models & Mechanisms, 2023 Lieve E. van der Maarel +2 more
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Translational Anatomy of the Sinoatrial Node [PDF]
JACC: Case ReportsAlejandro Jiménez Restrepo, MD +3 more
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Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
Journal of Cardiovascular Development and Disease, 2021 Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small proportion of the total mass of the heart yet must produce a stimulus of ...
Marietta Easterling +3 more
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