Results 1 to 10 of about 1,321,275 (276)
Genetic Complexity of Sinoatrial Node Dysfunction [PDF]
Frontiers in Genetics, 2021 The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND).
Michael J. Wallace +5 more
semanticscholar +5 more sources
Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis. [PDF]
Circulation, 2022 Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and ...
Zheng M +14 more
europepmc +2 more sources
The sinoatrial node, a heterogeneous pacemaker structure [PDF]
Cardiovascular Research, 2000 This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in terms of cell morphology, pacemaker activity, action potential configuration and conduction, densities of ionic currents (i(Na), i(Ca,L), i(to), i(K,r), i(K,s) and i(f)), expression of gap junction proteins (Cx40, Cx43 and Cx45), autonomic regulation, and ageing.
Mark R. Boyett
openalex +4 more sources
Computer modelling of the sinoatrial node [PDF]
Medical & Biological Engineering & Computing, 2007 Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential.
Ronald Wilders
openalex +5 more sources
Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity [PDF]
Frontiers in Cardiovascular Medicine, 2021 The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
D. Turner +6 more
semanticscholar +6 more sources
JAMA Oncol, 2022 Importance Atrial fibrillation (AF) can develop following thoracic irradiation. However, the critical cardiac substructure responsible for AF has not been properly studied.
Kim KH +13 more
europepmc +2 more sources
Telocytes in the human sinoatrial node [PDF]
Journal of Cellular and Molecular Medicine, 2017 The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells.
L. Mitrofanova +3 more
semanticscholar +4 more sources
Pharmacologic Approach to Sinoatrial Node Dysfunction.
Annual Review of Pharmacology and Toxicology, 2020 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sinoatrial node dysfunction (SND) and sick sinoatrial syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential.
P. Mesirca +6 more
semanticscholar +4 more sources
Myoarchitecture of the Sinoatrial Node and its Relevance for Catheter Ablation: Anatomy and Histology. [PDF]
JACC Case RepRestrepo AJ +3 more
europepmc +3 more sources