Results 1 to 10 of about 1,344,270 (316)

SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells

Circulation Research, 2022
Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to bradycardia.
Yuling Han, Jiajun Zhu, Liuliu Yang, Benjamin E. Nilsson-Payant, Romulo Hurtado, Lauretta A. Lacko, Xiaolu Sun, Aravind R. Gade, Christina A. Higgins, Whitney J. Sisso, Xue Dong, Maple Wang, Zhengming Chen, D. Ho, G. Pitt, R. Schwartz, B. tenOever, T. Evans, Shuibing Chen   +18 more
semanticscholar   +1 more source

Chemically defined and small molecules-based generation of sinoatrial node-like cells

Stem cell research & therapeutics, 2022
Background Existing methods for in vitro differentiation of human pluripotent stem cells (hPSCs) into sinoatrial node-like cells (SANLCs) require complex and undefined medium constituents.
Xiaojie Hou, Shuhong Ma, Wei-Fang Fan, Fang Li, Miaomiao Xu, Chao-shun Yang, Feng Liu, Ying Yan, Juyi Wan, F. Lan, Bin Liao   +10 more
semanticscholar   +1 more source

Association of Sinoatrial Node Radiation Dose With Atrial Fibrillation and Mortality in Patients With Lung Cancer.

JAMA Oncology, 2022
Importance Atrial fibrillation (AF) can develop following thoracic irradiation. However, the critical cardiac substructure responsible for AF has not been properly studied.
K. Kim, Jaewon Oh, Gowoon Yang, Joongyo Lee, Ji-Hong Kim, S. Gwak, Iksung Cho, Seung Hyun Lee, H. Byun, Hyo-Kyoung Choi, Jinsung Kim, J. Chang, Seok‐Min Kang, H. I. Yoon   +13 more
semanticscholar   +1 more source

Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics. [PDF]

PLoS ONE, 2014
Normal heart rhythm (sinus rhythm) is governed by the sinoatrial node, a specialized and highly heterogeneous collection of spontaneously active myocytes in the right atrium.
Patric Glynn, Birce Onal, Thomas J Hund
doaj   +1 more source

Junctional Pacemaker May Replace the Sinoatrial Node

Cardiovascular Innovations and Applications, 2021
Junctional rhythm is usually seen in the clinic with different causes. We report a case of bicuspid aortic valve accompanied by sinoatrial node dysfunction.
Min Lin, Yuqin Xiong, Yipin Lin, Yuhua Li, Lijuan Zhang   +4 more
doaj   +1 more source

Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction

Circulation, 2021
Supplemental Digital Content is available in the text. Background: The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN).
T. Mesquita, Rui Zhang, J. Cho, Rui Zhang, Yen-Nien Lin, L. Sanchez, J. Goldhaber, Joseph Yu, Jialiu A. Liang, Weixin Liu, N. Trayanova, E. Cingolani   +11 more
semanticscholar   +1 more source

Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue.
A. Kalyanasundaram, Ning Li, Miranda L Gardner, Esthela J. Artiga, Brian J. Hansen, A. Webb, Michael A. Freitas, Maciej Pietrzak, B. Whitson, N. Mokadam, P. Janssen, P. Mohler, V. Fedorov   +12 more
semanticscholar   +1 more source

The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability

Function, 2021
The cardiac cycle starts when an action potential is produced by pacemaking cells in the sinoatrial node. This cycle is repeated approximately 100 000 times in humans and 1 million times in mice per day, imposing a monumental metabolic demand on the ...
N. Grainger, L. Guarina, Robert H. Cudmore, L., Fernando Santana   +4 more
semanticscholar   +1 more source

Anatomopathological changes in canine distemper seropositive dogs and virus detection in sinoatrial nodes

Bioscience Journal, 2020
Canine distemper is a viral disease that affects several systems on dogs, among them, the cardiovascular system. The aim of this study was to identify canine distemper virus (CDV) in the sinoatrial node (SAN) of dogs serologically positive for distemper
José Eugenio Diniz Bastos, Neide Maria Silva, Marisol Patrícia Pallete Briceño, Tais Meziara Wilson, Alessandra Aparecida Medeiros-Ronchi   +4 more
doaj   +3 more sources

Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The funny current (If) is critical for spontaneous activity in cardiac pacemaker cells; however, its precise role remains enigmatic because it activates mostly outside the physiological voltage range and its kinetics are slow relative to the
C. Peters, Pin W. Liu, S. Morotti, Stephanie C. Gantz, E. Grandi, B. Bean, C. Proenza   +6 more
semanticscholar   +1 more source