Results 171 to 180 of about 12,234 (213)

Molecular Pathway for the Localized Formation of the Sinoatrial Node [PDF]

Circulation Research, 2007
The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been defined.
Mathilda T M Mommersteeg, Willem M H Hoogaars, Virginia E Papaioannou   +2 more
exaly   +5 more sources

Functional and morphological organization of the guinea-pig sinoatrial node compared with the rabbit sinoatrial node

Journal of Molecular and Cellular Cardiology, 1985
The primary pacemaker, i.e. the group of pacemaker cells discharging the sinoatrial node comprises less than 1000 cells in the guinea-pig and about 5000 cells in the rabbit. These primary pacemaker cells are described as 'central nodal' cells in light microscopy and as 'typical nodal' cells in electron microscopy.
T Opthof, W K Bleeker, H J Jongsma
exaly   +4 more sources

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Cardiac pacemaking in the sinoatrial node

Physiological Reviews, 1993
Major topics addressed in this review on cardiac pacemaking in the sinoatrial node are; 1) isolated pacemaker cells; 2) membrane currents of sinoatrial node cells; 3) mechanism of pacemaking; 4) regulation of pacemaker ...
H, Irisawa, H F, Brown, W, Giles
openaire   +2 more sources

Connexins in the Sinoatrial and Atrioventricular Nodes

2006
The sinoatrial node (SAN) and the atrioventricular node (AVN) are specialized tissues in the heart: the SAN is specialized for pacemaking (it is the pacemaker of the heart), whereas the AVN is specialized for slow conduction of the action potential (to introduce a delay between atrial and ventricular activation during the cardiac cycle).
Boyett, M. R., Inada, S., Yoo, S., Li, A. J., Liu, J., Tellez, J., Greener, I. D., Honjo, H., Billeter, R., Lei, M., Zhang, H., Efimov, I. R., Dobrzynski, H.; id_orcid 0000-0003-4754-5975   +12 more
openaire   +2 more sources

The surgical anatomy of the sinoatrial node

Surgical and Radiologic Anatomy, 1991
The sinoatrial nodes (SAN) were observed, dissected, and measured on 95 adults and 30 child hearts under a dissection microscope. The majority of the SANs in adults are characterized by their pale color, firm consistency, and the location in relation to the penetration of the SAN artery, and they can be located in the superior part of the terminal ...
B M, He, Y X, Tan, M, Cheng, Y Q, Cui
openaire   +2 more sources

Reconstruction of the human sinoatrial node

The Anatomical Record, 1967
AbstractThe superior vena cava and adjacent right atrium containing the sinoatrial node in each of five human hearts was studied histologically in serial section. The tissue block of a 41 year old man was reconstructed in four colors to provide a three‐dimensional model of the sinoatrial node, atrial relations, blood supply and nodal configuration. The
R C, Truex, M Q, Smythe, M J, Taylor
openaire   +2 more sources

The mammalian sinoatrial node

Cardiovascular Drugs and Therapy, 1988
The sinoatrial node (SAN) was discovered in 1906 by Keith and Flack. The relation between its ultrastructure and function was first studied by Trautwein and Uchizono in 1963, whereas this relation was definitely established by Taylor and coworkers in 1978. The impulse originates from cells with a relatively low percentage of myofilaments.
openaire   +2 more sources

STRUCTURE-FUNCTION RELATIONSHIPS OF THE SINOATRIAL NODE

International Journal of Bifurcation and Chaos, 2003
The sinoatrial node, the pacemaker of the heart, is a structurally and functionally complex and heterogeneous structure. Histology, immunohistochemistry, electrophysiology and mathematical modeling of the sinoatrial node are reviewed to reveal the structure-function relationships of the sinoatrial node. It is argued that contact between the sinoatrial
Halina Dobrzynski, Henggui Zhang, Sally E. Wright, Arun V. Holden, Mark R. Boyett   +4 more
openaire   +1 more source

Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways [PDF]

Progress in Biophysics and Molecular Biology, 2016
Despite a century of extensive study on the human sinoatrial node (SAN), the structure-to-function features of specialized SAN conduction pathways (SACP) are still unknown and debated. We report a new method for direct analysis of the SAN microstructure in optically-mapped human hearts with and without clinical history of SAN dysfunction.Two explanted ...
Jichao Zhao, Brian J Hansen, Ning Li
exaly   +4 more sources

Functional morphology of the pig sinoatrial node

Journal of Molecular and Cellular Cardiology, 1987
The porcine sinoatrial node in an isolated right atrium preparation is characterized by unifocal impulse generation. It has a rather elongated shape and the larger part of its volume is taken up by collagen and fibroblasts. The impulse appears to emerge from a site where the percentage of myofilaments is relatively low. The impulse is propagated faster
T, Opthof, B, de Jonge, H J, Jongsma, L N, Bouman   +3 more
openaire   +2 more sources