Results 41 to 50 of about 58,493 (121)

Is sodium current present in human sinoatrial node cells?

open access: yesInternational Journal of Biological Sciences, 2009
Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (INa) plays a role in the pacemaker activity of the human ...
Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
doaj  

The Relationship between Intracardiac Atrial Sensing Values and Atrial High-rate Episodes in Patients With Permanent Pacemakers Implanted due to Sick Sinus Syndrome

open access: yesHaseki Tıp Bülteni, 2022
Aim:An increase in fibrosis and collagen in the atrium and sinus node tissues constitutes the basic pathophysiology of sick sinus syndrome (SSS). We aimed to investigate the relationship between P-wave sensing values and atrial high rate episodes (AHRE ...
Sukru Arslan   +4 more
doaj   +1 more source

Desynchronization in heterogeneous networks due to uniform exposure [PDF]

open access: yesarXiv, 2018
We study synchronization and rhythmic patterns generated in the heterogeneous cluster of FitzHugh$-$Nagumo oscillators with transition between self-oscillating and excitable elements. Such cluster models the sinoatrial node of the heart, and the particular point of focus is the role of different physiological responses to mechanical stress: stretch ...
arxiv  

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

open access: yesFrontiers in Physiology, 2015
The heart’s regular electrical activity is initiated by specialized cardiac pacemaker cells residing in the sinoatrial node. The rate and rhythm of spontaneous action potential firing of sinoatrial node cells are regulated by stochastic mechanisms that ...
Yael eYaniv   +2 more
doaj   +1 more source

Causal Scale Shift Associated with Phase Transition to Human Atrial Fibrillation [PDF]

open access: yesarXiv, 2018
An example of phase transition in natural complex systems is the qualitative and sudden change in the heart rhythm between sinus rhythm and atrial fibrillation (AF), the most common irregular heart rhythm in humans. While the system behavior is centrally controlled by the behavior of the sinoatrial node in sinus rhythm, the macro-scale collective ...
arxiv  

A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia

open access: yesJournal of Pharmacological Sciences, 2015
Although it has been reported that endotoxin-induced expression of Nox1 in the heart contributes to apoptosis in cardiomyocytes, functional role of Nox1 at the physiological expression level has not been elucidated.
Akiteru Kojima   +7 more
doaj   +1 more source

Optimal Jammer Placement in Wireless Localization Systems [PDF]

open access: yes, 2016
In this study, the optimal jammer placement problem is proposed and analyzed for wireless localization systems. In particular, the optimal location of a jammer node is obtained by maximizing the minimum of the Cramer-Rao lower bounds (CRLBs) for a number of target nodes under location related constraints for the jammer node.
arxiv   +1 more source

Do human sinoatrial node cells have t-tubules?

open access: yesTranslational Research in Anatomy, 2021
Every heartbeat is generated by spontaneously depolarizing specialised nodal cells that make up the sinoatrial node (SN). The SN's unique properties depend on two complex mechanisms - the membrane-voltage and the Ca2+ clocks, regulated by strictly ...
Maria A. Petkova, Halina Dobrzynski
doaj  

Recursive, parameter-free, explicitly defined interpolation nodes for simplices [PDF]

open access: yesarXiv, 2020
A rule for constructing interpolation nodes for $n$th degree polynomials on the simplex is presented. These nodes are simple to define recursively from families of 1D node sets, such as the Lobatto-Gauss-Legendre (LGL) nodes. The resulting nodes have attractive properties: they are fully symmetric, they match the 1D family used in construction on the ...
arxiv  

Use of machine learning and Poincaré density grid in the diagnosis of sinus node dysfunction caused by sinoatrial conduction block in dogs

open access: yesJournal of Veterinary Internal Medicine
Background Sinus node dysfunction because of abnormal impulse generation or sinoatrial conduction block causes bradycardia that can be difficult to differentiate from high parasympathetic/low sympathetic modulation (HP/LSM).
Wyatt Hutson Flanders   +2 more
doaj   +1 more source

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