Results 41 to 50 of about 9,952 (192)
Journal of Pharmacological Sciences, 2004 Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node ...
Kentaro Takeda +4 more
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Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity
Frontiers in Cardiovascular Medicine, 2021 The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century.
Daniel Turner +6 more
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The Sinoatrial Node: Cell Size Does Matter [PDF]
Circulation Research, 2007 To the Editor: The key point of the recently published report in Circulation Research 1 by Lyashkov et al is that action potential characteristics (including beating rate) and Ca2+ handling are independent of the size of the sinoatrial node (SAN) cell in the rabbit.
Boyett, M. R. +6 more
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British Journal of Educational Psychology, EarlyView.Abstract Background Research on the role of the physical school environment in areas other than educational psychology has documented the benefits of exposure to nature for cognitive and emotional functioning. Positive effects have been indicated not only after a break in nature in mentally fatigued students but also in students who did not have ...
Lucia Mason +3 more
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background Pulmonary vein isolation (PVI) using thermal energy—radiofrequency (RF) or cryoablation (CRYO)—is associated with direct myocardial injury and collateral neural damage. In contrast, pulsed electric field (PEF) energy has emerged as a neural‐sparing alternative.
Predrag Stojadinović +12 more
wiley +1 more source
Mathematical Models of Cardiac Pacemaking Function
Frontiers in Physics, 2013 Over the past half century, there has been intense and fruitful interaction between experimental and computational investigations of cardiac function. This interaction has, for example, led to deep understanding of cardiac excitation-contraction coupling;
Pan eLi +3 more
doaj +1 more source
Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium [PDF]
PeerJ, 2017 Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity.
Jesús Hernandez-Cascales
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Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background Procedural and clinical outcomes in patients with obesity undergoing catheter ablation for atrial fibrillation (AF) have been mixed. Clinical data in the context of pulsed field ablation (PFA) are currently limited in this patient cohort.
Francis J. Ha +6 more
wiley +1 more source
Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
Nature Communications, 2021 The spontaneous bioelectrical activity of pacemaker cells in sinoatrial node (SAN) triggers the heartbeats. Here, the authors perform single-cell RNA sequencing in the mouse SAN and identify molecular and cellular features of the SAN conserved in rabbit ...
Dandan Liang +15 more
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Function and Dysfunction of Human Sinoatrial Node [PDF]
Korean Circulation Journal, 2015 Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release). Using optical mapping in Langendorff-perfused canine right atrium, we previously demonstrated that the β-adrenergic stimulation pushes the ...
Joung, Boyoung, Chen, Peng-Sheng
openaire +3 more sources