Results 41 to 50 of about 1,344,270 (316)
Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons
Protein & Cell, 2021 Activation of the heart normally begins in the sinoatrial node (SAN). Electrical impulses spontaneously released by SAN pacemaker cells (SANPCs) trigger the contraction of the heart. However, the cellular nature of SANPCs remains controversial.
Dandan Liang +17 more
semanticscholar +1 more source
Atrial and Sinoatrial Node Development in the Zebrafish Heart
Journal of Cardiovascular Development and Disease, 2021 Proper development and function of the vertebrate heart is vital for embryonic and postnatal life. Many congenital heart defects in humans are associated with disruption of genes that direct the formation or maintenance of atrial and pacemaker ...
Kendall E. Martin, J. Waxman
semanticscholar +1 more source
Lithium-Induced Sinoatrial Node Dysfunction [PDF]
Cureus, 2021 Lithium is a common mood-stabilizing drug for manic patients. We describe a case of sinoatrial node dysfunction in a patient with serum lithium levels within the therapeutic range. Given the symptomology and severity of the patient's illness, after placing a permanent pacemaker, the patient was discharged on the preadmission dose of lithium.
Sarangi, Ashish +3 more
openaire +2 more sources
Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout
Stem Cell Research, 2022 T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu +5 more
doaj +1 more source
Nature Communications, 2020 It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate regulation by the autonomic nervous system.
S. Fenske +20 more
semanticscholar +1 more source
Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating [PDF]
, 2011 We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal ...
Markhasin, V. S. +3 more
core +3 more sources
The mind body problem, part three: ascension of sexual function to cerebral level [PDF]
, 2016 Physiologically, the somatic nervous system intervenes in external interaction between the body and environment, while autonomic nervous system ensures the functioning of internal organs.
Motofei, Ion G., Rowland, David L.
core +3 more sources
Endogenous driving and synchronization in cardiac and uterine virtual tissues: bifurcations and local coupling [PDF]
, 2006 Cardiac and uterine muscle cells and tissue can be either autorhythmic or excitable. These behaviours exchange stability at bifurcations produced by changes in parameters, which if spatially localized can produce an ectopic pacemaking focus.
Benson, A.P. +4 more
core +1 more source
Journal of Pharmacological Sciences, 2005 Calcium channels are essential for excitation-contraction coupling and pacemaker activity in cardiac myocytes. While L-type Ca2+ channels (LCC) have been extensively studied, functional roles of T-type channels (TCC) in native cardiac myocytes are still ...
Kyoichi Ono, Toshihiko Iijima
doaj +1 more source
Computer Modelling of the Sinoatrial Node [PDF]
Medical & Biological Engineering & Computing, 2006 Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential.
openaire +4 more sources