Results 61 to 70 of about 1,311,541 (283)

Desmin is essential for the structure and function of the sinoatrial node; implications for increased arrhythmogenesis.

American Journal of Physiology. Heart and Circulatory Physiology, 2020
Our objective was to investigate the effect of desmin depletion on the structure and function of the sinoatrial pacemaker complex, (SANcl) and their implication in arrhythmogenesis.
M. Mavroidis, Nikolaos C. Athanasiadis, P. Rigas, I. Kostavasili, I. Kloukina, W. P. te Rijdt, N. Kavantzas, D. Chaniotis, J. V. van Tintelen, I. Skaliora, C. Davos   +10 more
semanticscholar   +1 more source

Sinoatrial node dysfunction and deafness

Definitions, 2020
Sinoatrial node dysfunction and deafness is a rare genetic disease characterized by congenital severe to profound deafness with no evidence of vestibular dysfunction, associated with sinoatrial node dysfunction with pronounced bradycardia and increased ...

semanticscholar   +1 more source

Gap junctions in the rabbit sinoatrial node [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2001
In comparison to the cellular basis of pacemaking, the electrical interactions mediating synchronization and conduction in the sinoatrial node are poorly understood. Therefore, we have taken a combined immunohistochemical and electrophysiological approach to characterize gap junctions in the nodal area.
Marjan J. A. van Kempen, Sjoerd Postma, Habo J. Jongsma, Martin B. Rook, Sander Verheule   +4 more
openaire   +3 more sources

Genetic Abnormalities of the Sinoatrial Node and Atrioventricular Conduction

Cardiac Electrophysiology Clinics, 2021
The peculiar electrophysiological properties of the sinoatrial node and the cardiac conduction system are key components of the normal physiology of cardiac impulse generation and propagation. Multiple genes and transcription factors and metabolic proteins are involved in their development and regulation.
Porta Sánchez, Andreu, Giuliana Priori, Silvia   +1 more
openaire   +6 more sources

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes [PDF]

, 2010
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone ...
A Benians, A Benians, A Benians, A Noma, AM Tolkovsky, Andrew Tinker, C Cifelli, C Marionneau, CE Ford, CL Huang, D Dobrev, D Dobrev, EN Nikolov, G Krapivinsky, I Riven, I Savelieva, J Gehrmann, JB Blumer, JL Leaney, JL Leaney, K Hu, K Wickman, L Sartiani, LC Mace, M Baruscotti, M Bechem, M Nobles, M Xia, M Yamada, MC Wellner-Kienitz, MD Drici, Muriel Nobles, N Lavine, N Voigt, O Wiser, Q Zhang, RB Robinson, S Fujita, S Peleg, SM Clancy, SM White, Sonia Sebastian, WA Boyle, WC Claycomb, Z Zuberi   +44 more
core   +2 more sources

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +15 more
wiley   +1 more source

Three-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behaviours.

PLoS ONE, 2014
The aim of the study was to develop a three-dimensional (3D) anatomically-detailed model of the rabbit right atrium containing the sinoatrial and atrioventricular nodes to study the electrophysiology of the nodes. A model was generated based on 3D images
Jue Li, Shin Inada, Jurgen E Schneider, Henggui Zhang, Halina Dobrzynski, Mark R Boyett   +5 more
doaj   +1 more source

Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium [PDF]

PeerJ, 2017
Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity.
Jesús Hernandez-Cascales
doaj   +2 more sources

A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart [PDF]

, 1982
These experiments employ the photoisomerizable compound, 3,3'-bis- [alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium. In homogenates from the heart, trans-Bis-Q blocks the binding of [3H]-N-
Birdsall, Nigel J. M., Erlanger, Bernard F., Lester, Henry A., Nargeot, Joel, Stockton, Jane, Wassermann, Norbert H.   +5 more
core   +1 more source

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

ESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher, Roger Hodkinson, William Makis, Peter A. McCullough   +3 more
wiley   +1 more source