Results 61 to 70 of about 1,321,275 (276)

Sphingosine‐1‐Phosphate Receptor Modulators for the Treatment of Ulcerative Colitis: A Narrative Review Focusing on Safety

United European Gastroenterology Journal, EarlyView.
ABSTRACT Ulcerative colitis is a chronic immune‐mediated inflammatory disease of the colon that causes considerable morbidity and increases the risk of colorectal cancer. Several targeted therapies have been developed for moderate‐to‐severe ulcerative colitis, significantly improving its management.
Massimo C. Fantini, Diego Centonze, Giovanni Giacobazzi, Silvia Benemei, Emanuele Romeo   +4 more
wiley   +1 more source

Electrocardiography in horses, part 2: how to read the equine ECG [PDF]

, 2010
The equine practitioner is faced with a wide variety of dysrhythmias, of which some are physiological. The recording of an exercise electrocardiogram (ECG) can help distinguish between physiological and pathological dysrhythmias, underlining the ...
De Clercq, Dominique, Decloedt, Annelies, Deprez, Piet, Sys, Stanislas, van Loon, Gunther, Verheyen, Tinne   +5 more
core  

Local delivery of fluorescent dye for fiber-optics confocal microscopy of the living heart [PDF]

, 2014
Fiber-optics confocal microscopy (FCM) is an emerging imaging technology with various applications in basic research and clinical diagnosis. FCM allows for real-time in situ microscopy of tissue at sub-cellular scale.
Aditya K. Kaza, Chao eHuang, Frank B. Sachse, Frank B. Sachse, Robert B. Hitchcock   +4 more
core   +2 more sources

The Calcium and Voltage Clocks in Sinoatrial Node Automaticity [PDF]

Korean Circulation Journal, 2009
Recent evidence indicates that the voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release) jointly regulate sinoatrial node (SAN) automaticity. Since the intact SAN is a heterogeneous structure that includes multiple different cell types interacting with each ...
Boyoung Joung, Shien-Fong Lin, Masahiro Ogawa, Peng Sheng Chen   +3 more
openaire   +4 more sources

Volume kinetics of lactated Ringer's solution in adult horses

Equine Veterinary Journal, EarlyView.
Abstract Background Fluid therapy in horses is primarily empirical. Evidence‐based quantification of the disposition of intravenous (IV) crystalloids used in clinical practice could enhance the effectiveness of fluid therapy. Objectives To determine the pharmacokinetics (i.e., volume kinetics: VK) and associated haemodynamic effects of IV lactated ...
William W. Muir, Xiu Ting Yiew, Shane W. Bateman, Robert G. Hahn   +3 more
wiley   +1 more source

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium [PDF]

, 2009
Cardiac sodium channels are responsible for conduction in the normal and diseased heart. We aimed to investigate regional and transmural distribution of sodium channel expression and function in the myocardium.
A. A. M. Wilde, A. O. Verkerk, B. P. Scicluna, C. A. Remme, C. Annink, C. R. Bezzina, J. M. T. Bakker, M. J. B. den Hoff, M. W. Veldkamp, T. A. B. Veen, V. M. Christoffels, W. M. H. Hoogaars, W. T. J. Aanhaanen   +12 more
core   +3 more sources

Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice

Development, 2019
The sinoatrial node (SAN), the primary cardiac pacemaker, consists of a head domain and a junction/tail domain that exhibit different functional properties. However, the underlying molecular mechanism defining these two pacemaker domains remains elusive.
Hua Li, Dainan Li, Yuzhi Wang, Zhen Huang, Jue Xu, Tianfang Yang, Linyan Wang, Q. Tang, C. Cai, Hai Huang, Yanding Zhang, YiPing Chen   +11 more
semanticscholar   +1 more source

The morphologic development of the sinoatrial node in the mouse

The American Journal of Cardiology, 1970
Abstract A plastic embedding technique was employed on mouse embryos after fixation with a gluteraldehyde-paraformaldehyde mixture and preparation of large, 1 to 2 μ sections cut on a rotary microtome with steel knives. It was then possible to trace the sinoatrial node back to mouse embryos of 4 sol1 2 mm crown-rump length ( 10 1 2 days
Departments of Pediatrics (Cardiology) and Pathology, University of Florida College of Medicine, Gainesville, Fla. 32601 USA ( host institution ), Van Mierop, L.H.S., Gessner, Ira H.   +2 more
openaire   +4 more sources

Systolic‐dominant coronary flow in rats and mice: Challenging the diastolic paradigm across conscious and anaesthetized states

Experimental Physiology, EarlyView.
Abstract Extensive research in humans, dogs, rabbits, rats, mice and other mammals has consistently demonstrated that coronary blood flow (CBF) peaks during ventricular diastole. For example, studies using transthoracic Doppler echocardiography in anaesthetized rats and mice, isolated blood‐perfused rat hearts and Doppler probes sutured to the ...
Heidi L. Lujan, Theodore W. Kurtz, Stephen E. DiCarlo   +2 more
wiley   +1 more source

The Evolution of Sinoatrial Node Function in Man [PDF]

, 1973
The function of the sinoatrial node is complex. In nearly all hearts, this small bit of tissue is responsible for spontaneously generating the impulse which will be distributed to the remainder of the heart, maintaining coordinated electrical and ...
Bigger, J. Thomas, Strauss, Harold C.
core   +1 more source