Results 31 to 40 of about 2,377 (150)
Siponimod vs placebo in active secondary progressive multiple sclerosis: a post hoc analysis from the phase 3 EXPAND study. [PDF]
, 2022 BACKGROUND
Siponimod is a sphingosine 1-phosphate receptor modulator approved for active secondary progressive multiple sclerosis (aSPMS) in most countries; however, phase 3 EXPAND study data are from an SPMS population with/without disease activity ...Fox, Robert J, Cree, Bruce AC, Bar-Or, Amit, Fox, Robert J., Benedict, Ralph H. B., Vermersch, Patrick, Hach, Thomas, Rouyrre, Nicolas, Karlsson, Göril, Gold, Ralf, Benedict, Ralph HB, Dahlke, Frank, Kappos, Ludwig, Ritter, Shannon, Cree, Bruce A C, Arnold, Douglas L., Arnold, Douglas L, Kilaru, Ajay, Cree, Bruce A. C., Giovannoni, Gavin, Penner, Iris-Katharina, Benedict, Ralph H B, Piani-Meier, Daniela +22 morecore +2 more sourcesNovel real world evidence from mSGo, a digital support program for secondary Progressive multiple sclerosis patients in Australia using siponimod
, 2022 Introduction: Siponimod is approved in Australia for adults with secondary progressive multiple sclerosis (SPMS). Prescreen requirements for siponimod include a CYP2C9 genotype test to determine maintenance dosing. An integrated digital platform, ‘MSGo’, Hardy, T, Hodgkinson, S, McCombe, P, Broadley, S, Crimmins, D, Barnett, M, Parratt, J, Lee, A, Plummer, C, Lechner-Scott, J, Carroll, W, Blum, S, Malhotra, R, Griffiths, D, Aouad, P, et al. +15 morecore +1 more sourceNovel generation of real world evidence through MSGo, a digital support program supporting the use of siponimod in secondary progressive multiple sclerosis patients in Australia
, 2021 Introduction:
Siponimod is approved in Australia for adults with secondary progressive multiple sclerosis (SPMS). Initiating siponimod involves prescreening tests, including a CYP2C9 genotype test to determine siponimod maintenance dosing.Hardy, T, Hodgkinson, S, McCombe, P, Broadley, S, Crimmins, D, Barnett, M, Parratt, J, Lee, A, Plummer, C, Lechner-Scott, J, Carroll, W, Blum, S, Malhotra, R, Griffiths, D, Aouad, P, et al. +15 morecore +1 more sourceNovel Real World Evidence from MSGo, a Digital Support Program for Secondary Progressive Multiple Sclerosis Patients in Australia using Siponimod
, 2023 Background: Siponimod is approved in Australia for adults with secondary progressive multiple sclerosis (SPMS). Prescreen requirements for siponimod include a CYP2C9 genotype test to determine maintenance dosing.Broadley, Simon, Malhotra, Ram, Aouad, Patrick, Griffiths, Dayna, Hodgkinson, Suzanne, Lee, Andrew, Blum, Stefan, Plummer, Christopher, Barnett, Michael, Lechner-Scott, Jeannette, Crimmins, Denis, Hardy, Todd, McCombe, Pamela, Carroll, William, Parratt, John, et al. +15 morecore +1 more sourceThe Benefits and Risks of Switching from Fingolimod to Siponimod for the Treatment of Relapsing–Remitting and Secondary Progressive Multiple Sclerosis
Drugs in R&D, 2023 Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system (CNS). Currently, MS treatment is limited to several Food and Drug Administration (FDA)- and European Medicines Agency (EMA)-approved medications that ...Martin Vališ, Anat Achiron, Hans Peter Hartung, Jan Mareš, Veronika Tichá, Pavel Štourač, Simona Halusková, Francesco Angelucci, Zbyšek Pavelek +8 moredoaj +1 more sourceSiponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
, 2018 BACKGROUND:
No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS).Duquette, P, Rozsa, C, Gehring K., Salgado A. V., Mao-Draayer, Y, Uccelli A., Piedrabuena R., Becker V. U., Patrucco, L, Simo M., Hardiman O., Hupperts R., Sharrack B., West, T, Papeix C., Hancinova V., Stangel M., Saida T., Buraga I., Schmidt S., Solomon, A, Lutterotti A., Zhang M., Cahill, J, Scholz E., Xu, X, Debouverie, M, Tarnev I., Elias S., Nielsen A. S., Urtaza F. J. O., Fernandez, Of, Herbert J., Faiss J., Derfuss, T, Antel J. P., Cahill J., Cree, Bac, Herbert, J, Chan A., Tello C. R., Kurca E., Vachova M., Oreja-Guevara, C, Nakatsuji Y., Ford, C, Koves, A, Schlegel, E, Ford, H, Faiss, J, Boerner, T, Corboy, J, Yelamos S. M., Cooper J. A., Wolf, C, Pandolfo, M, Bergh F. T., Ticha V., Francia A., Montoya, L, Vachova, M, Schwartz R., Debouverie M., Montoya L., Merino, Jag, Kornhuber, A, Nocentini, U, Khatri, B, Heidenreich F. R., Macdonell R., Scherz, T, Salgado, Av, Ziemssen, T, Skoda, O, Gehring, K, Castelnovo, G, Grigoriadis, N, Steingo, B, Zhang, M, Coyle, Pk, Newsome, S, Sinay V., Millers, A, Pachner, A, Corboy J., Bowling, A, Lee, L, Nomura, K, Panczel, G, Cascione M., Balasa R., Rodriguez, Jm, Saccà, F, Scholz, E, Willekens B., Zacharias, A, Rauer S., da Silva, Am, Emrich P. J., Siva A., Hengstman, Gjd, Odinak, Mm, Mirabella, M, Rog D., Bhan V., Ford H., Rubin S., Siever A., Freedman, M, Lensch, E, Arnould, S, Berthele, A, Bonek, R, Maida E. -M., Krastev G., Stangel, M, Fernandez O. F., Komatineni, A, Pless, M, Karelis, G, Dioszeghy, P, Hengstman G. J. D., Nomura K., Karussis D., Zieman U., Zettl U., da Silva A. M., Brola W., Tumani H., Honeycutt, Wd, Shafer, S, Castelnovo G., Strassburger-Krogias K., Sigel, K, Tumani, H, Odinak M. M., Cottrell, Da, Strassburger-Krogias, K, Tiel-Wilck K., Grigoriadis N., Freedman M., Harmjanz A., Visser L. H., Laureys G., Tiel-Wilck, K, Bracknies V., Liskova, P, Vermersch P., Achiron A., Dihenia B., Markowitz C., Applebee, Am, Mihetiu, Ig, Huang, Y, Wiertlewski, S, Buraga, I, Rizvi, Sa, Rodriguez J. M., Cohan, S, Huang, D, Robertson, D, Fox, Rj, Frishberg B., Patrucco L., Cui L., Schlegel E., Skoda O., Yamamura, T, Herring M., Ferrer, Fc, Dahlke F., Rowe V., Cimprichova, A, Matyas, K, Ferrer F. C., Liskova P., Guillaume, D, Rizvi S. A., Efendi H., Stourac, P, Schwab, M, Matyas K., Sigel K. -O., Toomsoo, T, Bejinariu M., Hoffmann O. M., Elias, S, Gudesblatt, M, Scarpini E. A., Bar-Or A., Boerner T., Antiguedad, Ar, Shchukin, Ia, Tello, Cr, Derfuss T., Scott J., Decoo, D, Barnett, M, van Oosten B. W., Boyko, An, Tubridy, N, Donath V., Harmjanz, A, Hua, Lh, Vorobeychik, G, Stolyarov I. D., Scott, J, Feneberg W., Ticha, V, Coyle P. K., Linker R. A., Weissert R., Scherz T., Brochet B., Herring, M, Calkwood, Jc, Satori, M, Gross J., Maida, E, Kurca, E, Jacobs A. K., Grigorova O., Wallstrom E., Meca-Lallana J., Ticmeanu, M, Ayuso, Gi, Antel, Jp, Hua L. H., Garmany, Gp, Mirabella M., Millers A., Gross, J, Rog, D, Leutmezer F., Meca-Lallana, J, Uccelli, A, Koves A., Gudesblatt M., Giovannoni G., Khatri B., Costell, B, Boz C., Brozman M., Wolf C., Barnett M., Newsome S., Balci B. P., Bjork, Rj, Pless M., Papeix, C, Nohara C., Vermersch, P, Fermont J., Klimova, E, Montalban, X, Lycke, J, Haas J., Camu W., Kimura T., Pandolfo M., Goldstick, Lp, Komatineni A., Calkwood J. C., Dahlke, F, de Sa J., Czlonkowska, A, Fermont, J, Balci, Bp, Bischof, F, Imre, P, Tavernarakis, A, Allen A. B., Pachner A., Scarpini, Ea, Ticmeanu M., Efendi, H, Schwab M., Balasa, R, Tullman, Mj, Schluep, M, Antiguedad A. R., Kalnina J., Hancu, A, Stefoski D., Krupp, Lb, Mueller, S, Siquier, Ae, Kalnina, J, Becker, Vu, Haas, J, Lycke J., Kozubski W., Sinay, V, Estruch, Bc, van Oosten, Bw, Baba, M, Shafer S., Kaprelyan, A, Weber, Jr, Shimizu Y., Yeung, M, Wildemann B., Guillaume D., Sazonov, Dv, Vorobeychik G., Tarnev, I, Brescia Morra, V, Jakab G., Strauss E., Polzer U., Leutmezer, F, Bowen, Jd, Fedyanin, As, Decoo D., de Sa, J, Wiertlewski S., Deri N. H., Karussis, D, Marfia, Ga, Cohan S., Zieman, U, Van Wijmeersch B., Simu, M, Giovannoni, G, Kister, I, Shimizu, Y, Linker, Ra, Edan G., Sanchez V. E. F., Bracknies, V, Stuve, O, Pozsegovits K., Roshanisefat H., Bischof F., Li H., Burnett, M, Debruyne J., Shotekov P., Koehler, J, Shchukin I. A., Pozsegovits, K, Llanera C., Yeung M., Weissert, R, Kizlaitiene R., Mastorodimos V., Defer G., Silliman, S, Butzkueven, H, Bajenaru O., Braune S., Cimprichova A., Correale J., Kaprelyan A., Olsson, T, Blevins, G, Kappos, L, Grandmaison, F, Huang Y., Correale, J, Imre P., Miller A. E., Krupp L. B., Terzi, M, Rey R., Heidenreich, Fr, Simu M., Agan, K, Brunet, D, Donath, V, Dubois, B, Brochet, B, Centonze, D, Jasinska, E, Agan K., Emrich, Pj, Mao-Draayer Y., Garmany G. P., Selmaj, K, Grimaldi L. M. E., Siquier A. E., Turner B., Mori, M, Kappos L., Rastenyte, D, Gross-Paju, K, Brownstone P. K., Allen, Ab, Buttmann M., Maeurer M., Zhou H., Sanchez, Vef, Debruyne, J, Gross-Paju K., Klimova E., Costell B., Jakab, G, Bergmann, A, Siva, A, Baba M., Rowe, V, Boz, C, Hoffmann, Om, Sazonov D. V., Bowen J. D., Lassek C., Schluep M., Gonzalez R. A., Valikovics, A, Bass, A, Galgani S., Nikfekr, E, Schrijver H. M., Strauss, E, Arnold D. L., Walter, S, Centonze D., Gitt, J, Bernitsas, E, Malciene, L, Fox R. J., Brunet D., Grandmaison F., Nielsen, As, Sanders, K, Brozman, M, Terzi M., Akman-Demir G., Edan, G, Nohara, C, Weber J. R., Gitt J., Hodgkinson S., Lu J., Sanders K., Feneberg, W, Mori M., Rey, R, Bajenaru, O, Schrijver, Hm, Magzhanov R. V., Weiss, S, Czlonkowska A., Mueller S., Defer, G, Hancinova, V, Francia, A, Craner M., Cerqueira J., Gobbi C., Tavernarakis A., Kizlaitiene, R, Katz, A, Li, H, Hancu A., Tubridy N., Cerqueira, J, Grigorova, O, Roshanisefat, H, Burnett M., Malciene L., Rusek S., Reifschneider, G, Kister I., Bejinariu, M, Wildemann, B, Gold R., Kovacs K., Sacca F., Yang Y. N., Miller, Ae, Polzer, U, Boyko A. N., Kovacs, K, Nicholas R., Khabirov F. A., Jacobs, Ak, Stefoski, D, Kaida, K, Tullman M. J., Maciejowski, M, Stourac P., Koehler J., Akman-Demir, G, Stolyarov, Id, Comi, G, Saida, T, Oschmann P., Craner, M, Merino J. A. G., Satori M., Ayuso G. I., Van Wijmeersch, B, Kaida K., Camu, W, Cree B. A. C., Brescia Morra V., Achtnichts, L, Macdonell, R, Schmidt, S, Sharrack, B, Cui, L, Nakahara, J, Dioszeghy P., Fink, K, Montalban X., Cottrell D. A., Jasinska E., Kozubski, W, Rastenyte D., Hupperts, R, Olsson T., Braune, S, Karelis G., Nikfekr E., Silliman S., Llanera, C, Zelkowitz M., Bhan, V, Brola, W, Lensch E., Maciejowski M., Krastev, G, Pelletier, J, Achtnichts L., Panczel G., Yelamos, Sm, Mizuno M., Nakahara J., Brownstone, Pk, Lutterotti, A, Dubois B., Laureys, G, Kornhuber A., Wiendl, H, Schwartz, R, Cooper, Ja, Bergmann A., Nocentini U., Lassek, C, Turner, B, Cascione, M, Piedrabuena, R, Bowling A., Bergh, Ft, Turcani, P, Valikovics A., Kimura, T, Ford C., Comi G., Rozsa C., Wallström, E, Lu, J, West T., Ziemssen T., Steingo B., Hardiman, O, Arnold, Dl, Visser, Lh, Grimaldi, Lme, Lee L., Apperson, M, Hofmann W. E., Overell J., Honeycutt W. D., Oreja-Guevara C., Reifschneider G., Hodgkinson, S, Achiron, A, Bonek R., Gonzalez, Ra, Zettl, U, Zelkowitz, M, Robertson D., Galgani, S, Willekens, B, Linnebank, M, Overell, J, Magzhanov, Rv, Rauer, S, Huang D., Cunha L., Mastorodimos, V, Nakatsuji, Y, Urtaza, Fjo, Stuve O., Rubin, S, Evdoshenko E. P., Gobbi, C, Wiendl H., Zhou, H, Arnould S., Duddy M., Vanopdenbosch, L, Boehringer, M, Khabirov, Fa, Bass A., Katz A., Blevins G., Selmaj K., Buttmann, M, Duquette P., Oschmann, P, Applebee A. M., Zacharias A., Apperson M., Weiss S., Xu X., Walter S., Hofmann, We, Bjork R. J., Siever, A, Gold, R, Milanov, I, Shotekov, P, Goldstick L. P., de Seze, J, Pelletier J., Markowitz, C, Berthele A., Linnebank M., Bar-Or, A, Simo, M, Estruch B. C., Nicholas, R, Turcani P., Fedyanin A. S., Milanov I., Conway J., de Seze J., Duddy, M, Chan, A, Marfia G. A., Mihetiu I. G., Rusek, S, Maeurer, M, Cunha, L, Fink K., Dihenia, B, Yamamura T., Evdoshenko, Ep, Deri, Nh, Frishberg, B, Mizuno, M, Yang, Yn, Conway, J, Boehringer M., Bernitsas E., Vanopdenbosch L., Butzkueven H., Toomsoo T., Solomon A. +651 morecore +4 more sources
